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181.
Dahae Lee Yuri Ko Changhyun Pang Yoon-Joo Ko You-Kyoung Choi Ki Hyun Kim Ki Sung Kang 《Molecules (Basel, Switzerland)》2022,27(1)
Armillariella tabescens (Scop.) Sing., a mushroom of the family Tricholomataceae, has been used in traditional oriental medicine to treat cholecystitis, improve bile secretion, and regulate bile-duct pressure. The present study evaluated the estrogen-like effects of A. tabescens using a cell-proliferation assay in an estrogen-receptor-positive breast cancer cell line (MCF-7). We found that the methanol extract of A. tabescens fruiting bodies promoted cell proliferation in MCF-7 cells. Using bioassay-guided fractionation of the methanol extract and chemical investigation, we isolated and identified four steroids and four fatty acids from the active fraction. All eight compounds were evaluated by E-screen assay for their estrogen-like effects in MCF-7 cells. Among the tested isolates, only (3β,5α,22E)-ergost-22-en-3-ol promoted cell proliferation in MCF-7 cells; this effect was mitigated by the ER antagonist, ICI 182,780. The mechanism underlying the estrogen-like effect of (3β,5α,22E)-ergost-22-en-3-ol was evaluated using Western blot analysis to detect the expression of extracellular signal-regulated kinase (ERK), phosphatidylinositol 3-kinase (PI3K), Akt, and estrogen receptor α (ERα). We found that (3β,5α,22E)-ergost-22-en-3-ol induced an increase in phosphorylation of ERK, PI3K, Akt, and ERα. Together, these experimental results suggest that (3β,5α,22E)-ergost-22-en-3-ol is responsible for the estrogen-like effects of A. tabescens and may potentially aid control of estrogenic activity in menopause. 相似文献
182.
Polypyrrole, formed in an organic solvent, shows higher density and better quality in electrical conductivity and mechanical strength than that formed in water. On electrochemical reduction in an aqueous system the laurylsulfate anion, used as dopant, sticks to the polymer. During reduction a cation moves into the polymer and on oxidation it leaves the polymer. The anion, however, leaves the polymer on reduction in an organic solvent system and cannot penetrate into the polymer on re-oxidation. The redox reaction in the aqueous system reveals a surface reaction process, while the reaction in the organic solvent system undergoes a diffusion-controlled process. This penomenon is consistant with the results of the ion concentration profile. 相似文献
183.
Keisuke Uematsu Chikara Hayasaka Ko Takase Keiichi Noguchi Koji Nakano 《Molecules (Basel, Switzerland)》2022,27(3)
[n]Helicenes with helically twisted structures have attracted increasing interest owing to their unique properties. Therefore, it has been an important issue to develop facile synthetic methodologies which allow access to a variety of [n]helicenes. Here we report the synthesis of [7]helicenes and [7]helicene-like compounds from the thia[7]helicene as a common starting material. Desulfurative dilithiation of the thia[7]helicene and the subsequent reaction with silicon and phosphorus electrophiles afforded the silole- and phosphole-fused [7]helicene-like compounds, respectively. The cyclopentadiene-fused [7]helicene-like compound and the pyrrole-fused aza[7]helicenes were also successfully synthesized via twofold SNAr reactions of the thia[7]helicene S,S-dioxide with the carbon and nitrogen nucleophiles, respectively. The thia[7]helicene S,S-dioxide showed a slightly red-shifted absorption spectrum than the parent thia[7]helicene, which was well demonstrated by the theoretical calculations. The substituents on the silicon atom of silole-fused [7]helicene-like compounds have little impact on the longest absorption maximum. Such little effect of the substituents on absorption properties was also observed for cyclopentadiene-fused [7]helicene-like compounds and aza[7]helicenes and was well demonstrated by the theoretical calculations. The thia[7]helicene S,S-dioxide and the silole-fused [7]helicene-like compound exhibited bright blue emission, and the cyclopentadiene-fused [7]helicene-like compound and the aza[7]helicenes showed strong violet emission. Each single enantiomer of the aza[7]helicenes showed circularly-polarized luminescence with the dissymmetry factors of 4.2~4.4 × 10−3. 相似文献
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Michelia formosana (Kanehira) Masamune is a broad-leaved species widespread in East Asia; the wood extract and its constituents possess antifungal activity against wood-decay fungi. Antifungal activities of leaf essential oil and its constituents from M. formosana were investigated in the present study. Bioassay-guided isolation was applied to isolate the phytochemicals from leaf essential oil. 1D and 2D NMR, FTIR, and MS spectroscopic analyses were applied to elucidate the chemical structures of isolated compounds. Leaf essential oil displayed antifungal activity against wood decay fungi and was further separated into 11 fractions by column chromatography. Four sesquiterpenoids were isolated and identified from the active fractions of leaf essential oil through bioassay-guided isolation. Among these sesquiterpenoids, guaiol, bulnesol, and β-elemol have higher antifungal activity against brown-rot fungus Laetiporus sulphureus and white-rot fungus Lenzites betulina. Leaf essential oil and active compounds showed better antifungal activity against L. sulphureus than against L. betulina. The molecular structure of active sesquiterpenoids all contain the hydroxyisopropyl group. Antifungal sesquiterpenoids from M. formosana leaf essential oil show potential as natural fungicides for decay control of lignocellulosic materials. 相似文献
186.
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188.
Jooung-Hyun Jo Hyun-Cheol Ko Byeong-Woo Kim Hyun Park In-won Lee Ho-Hwan Chun 《Composite Interfaces》2016,23(8):797-805
AbstractMarine fouling can be a serious problem in the shipping industry, since it increases the surface roughness of the hull and hence its frictional resistance to its movement through water. Antifouling paint can be defined as preventing the attachment of marine organisms onto surfaces. However, the most commonly used antifouling coating which is the tributyltin-based self-polishing copolymer causes the severe pollution of marine environment. Ammonium salt-based paints include tertiary amines as biocides which have effective biocidal and biodegradable properties without accumulation in the sea environment. However, ammonium salt-based coatings were too sensitive to seawater and became swollen. In this study, polyurethane-acrylic copolymers were synthesized by radical polymerization. These hybrid materials were found to form core–shell structures in aqueous media. Synthesis and properties of copolymers were investigated by Fourier transform-infrared spectrometer, proton-nuclear magnetic resonance, transmission electron microscopy, and dynamic light scattering. The polishing rate of self-polishing copolymer was determined from the reduction in dry film thickness after artificial seawater immersion under a dynamic condition. 相似文献
189.
Reagen Ying‐Tai Su Li‐Ko Chiu Shan‐Wei Weng Ying‐Shiun Chou Raymond Chien‐Chao Tsiang 《Journal of Polymer Science.Polymer Physics》2012,50(4):280-288
White polymeric light‐emitting diode (WPLED) based on a single polymer, poly(3‐hexylthiophene‐alt‐9,9‐dioctylfluorene) (PTAF), has been successfully demonstrated. This conjugated alternating copolymer, PTAF, comprises 50 mol % of 3‐hexylthiophene which is an orange‐red color chromophore and 50 mol % 9,9‐dioctylfluorene which is a bluish‐green color chromophore. It was synthesized by Suzuki cross‐coupling reaction and has a molecular weight of 15,021 and polydispersity of 1.36. Nanocomposite consisting PTAF and graphene nanosheets enhances the optoelectronic properties and the device fabricated with a configuration of ITO/PEDOT:PSS/(PTAF + 1% graphene)/Ca/Al shows two‐color white electroluminescence with CIE 1931 coordinates of (0.28, 0.34). The white luminescence from a single polymer affords the WPLED device a simple structure and low fabrication cost. © 2011 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2011 相似文献
190.