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131.
132.
Ruusunen Jarno Ihalainen Mika Koponen Tarmo Torvela Tiina Tenho Mikko Salonen Jarno Sippula Olli Joutsensaari Jorma Jokiniemi Jorma Lähde Anna 《Journal of nanoparticle research》2014,16(2):1-11
Enteric-coated formulations can delay the release of drugs until they have passed through the stomach. However, high concentration of drugs caused by rapidly released in the small intestine leads to the intestinal damage, and frequent administration would increase the probability of missing medication and reduce the patient compliance. To solve the above-mentioned problems, aspirin-loaded enteric-coated sustained-release nanoparticles with core–shell structure were prepared via one-step method using coaxial electrospray in this study. Eudragit L100-55 as pH-sensitive polymer and Eudragit RS as sustained-release polymer were used for the outer coating and inner core of the nanoparticles, respectively. The maximum loading capacity of nanoparticles was 23.66 % by changing the flow rate ratio of outer/inner solutions, and the entrapment efficiency was nearly 100 %. Nanoparticles with core–shell structure were observed via fluorescence microscope and transmission electron microscope. And pH-sensitive and sustained drug release profiles were observed in the media with different pH values (1.2 and 6.8). In addition, mild cytotoxicity in vitro was detected, and the nanoparticles could be taken up by Caco-2 cells within 1.0 h in cellular uptake study. These results indicate that prepared enteric-coated sustained-release nanoparticles would be a more safety and effective carrier for oral drug delivery. 相似文献
133.
Michael Hummel Mikko Leppikallio Sami Heikkinen Klaus Niemelä Herbert Sixta 《Journal of carbohydrate chemistry》2013,32(8-9):416-428
In acidic aqueous solutions the xylonic acid/xylonate equilibrium is coupled with the formation of the γ- and δ-lactones. The γ-lactone is formed more readily, whereas the δ-lactone can only be observed in traces at very low pH values (<2.5). By means of 13C NMR, both the lactone hydrolization constant and the acid dissociation constant could be determined (KL = 4.08, = 3.65 ± 0.34). Further, a second deprotonation of one of the hydroxyl groups could be observed at very high pH ( = 13.3 ± 0.76). 相似文献
134.
Dr. Mikko Linnolahti Dr. Anniina Laine Prof. Tapani A. Pakkanen 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(22):7133-7142
Herein, we introduce an approach for the computational screening of stoichiometric reactions between trimethylaluminum (TMA) and water. The thermodynamic products of these reactions are methylaluminoxanes (MAOs) with different compositions, which have the general formula (AlOMe)n(AlMe3)m, in which n describes the degree of oligomerization and m is the number of associated TMA molecules. These reaction products were thoroughly explored up to n=4, thus demonstrating the thermodynamically preferable association of up to four AlMe3 molecules, that is, TMA molecules in their monomeric form. The relative Lewis acidities of the Al sites in these MAOs were systematically explored and we found that the associated TMA molecules were a key ingredient for co‐catalytic activity in olefin‐polymerization catalysis. This conclusion was supported by computational studies on catalyst activation, which revealed an exergonic insertion of ethene into the metallocene/MAO complex. 相似文献
135.
Aqueous Self‐Assembly and Cation Selectivity of Cobaltabisdicarbollide Dianionic Dumbbells
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Màrius Tarrés Prof. Clara Viñas Patricia González‐Cardoso Dr. Mikko M. Hänninen Prof. Reijo Sillanpää Vladimír Ďorďovič Dr. Mariusz Uchman Prof. Francesc Teixidor Dr. Pavel Matějíček 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(22):6786-6794
The anion [3,3′‐Co(C2B9H11)2]? ([COSAN]?) produces aggregates in water. These aggregates are interpreted to be the result of C?H???H?B interactions. It is possible to generate aggregates even after the incorporation of additional functional groups into the [COSAN]? units. The approach is to join two [COSAN]? anions by a linker that can adapt itself to act as a crown ether. The linker has been chosen to have six oxygen atoms, which is the ideal number for K+ selectivity in crown ethers. The linker binds the alkaline metal ions with different affinities; thus showing a distinct degree of selectivity. The highest affinity is shown towards K+ from a mixture containing Li+, Na+, K+, Rb+ and Cs+; this can be indicative of pseudo‐crown ether performance of the dumbbell. One interesting possibility is that the [COSAN]? anions at the two ends of the linker can act as a hook‐and‐loop fastener to close the ring. This facet is intriguing and deserves further consideration for possible applications. The distinct affinity towards alkaline metal ions is corroborated by solubility studies and isothermal calorimetry thermograms. Furthermore, cryoTEM micrographs, along with light scattering results, reveal the existence of small self‐assemblies and compact nanostructures ranging from spheres to single‐/multi‐layer vesicles in aqueous solutions. The studies reported herein show that these dumbbells can have different appearances, either as molecules or aggregates, in water or lipophilic phases; this offers a distinct model as drug carriers. 相似文献
136.
Carlo Lovadina Mikko Lyly Rolf Stenberg 《Numerical Methods for Partial Differential Equations》2009,25(1):244-257
We consider the Stokes eigenvalue problem. For the eigenvalues we derive both upper and lower a‐posteriori error bounds. The estimates are verified by numerical computations. © 2008 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq, 2009 相似文献
137.
Vankka J. Waltari M. Kosunen M. Halonen K.A.I. 《Solid-State Circuits, IEEE Journal of》1998,33(2):218-227
A direct digital synthesizer (DDS) with an on-chip D/A converter is designed and processed in a 0.8 μm BiCMOS. The on-chip D/A converter avoids delays and line loading caused by interchip connections. At the 150 MHz clock frequency, the spurious free dynamic range (SFDR) is better than 60 dBc at low synthesized frequencies, decreasing to 52 dBc worst case at high synthesized frequencies in the output frequency band (0-75 MHz). The DDS covers a bandwidth from DC to 75 MHz in steps of 0.0349 Hz with the frequency switching speed of 140 ns. The chip has a complexity of 19100 transistors with a die/core area of 12.2/3.9 mm2. The power dissipation is 0.6 W at 150 MHz at 5 V. The maximum operating clock frequency of the chip is 170 MHz 相似文献
138.
Ari‐Pekka Hameri Mikael Puittinen Mikko Syrjlahti 《International Journal of Communication Systems》2002,15(7):607-619
Research on complex adaptive systems has generated several conceptual parables to explain systems with emergent behaviour. One prominent use for terms such as self‐organization, evolutionary trajectories, co‐evolution and punctuated equilibrium has been in understanding human organizations. In such systems, emergent behaviour is demonstrated in novel structures, processes and spin‐offs that cannot be explained just by studying single components of the organization and the intelligence embedded in them. Instead of solely exploiting the qualitative explanatory power of the evolutionary concepts, this paper focuses also on quantitative methods to track emergent behaviour in a globally distributed, constantly fluctuating and highly networked project organization. The underlying case is that of CERN (CERN, the European Laboratory for Particle Physics, has its headquarters in Geneva. At present, its Member States are Austria, Belgium, the Czech Republic, Denmark, Finland, France, Germany, Greece, Hungary, Italy, Netherlands, Norway, Poland, Portugal, the Slovak Republic, Spain, Sweden, Switzerland and the United Kingdom. Israel, the Russian Federation, Turkey, Yugoslavia (status suspended after the UN embargo, June 1992), the European Commission and UNESCO have observer status.) and its decade long accelerator project, which strongly relies on electronic communication and networking to achieve its major objectives due to be accomplished by the year 2006. By using time series and self‐organizing maps to analyse the global interaction among project groups and individuals the paper provides new insight to the understanding of emergent behaviour in human organizations. The key result of the study concerns the rigid deep structure of each case organization that seems to remain intact for the duration of the whole project. Copyright © 2002 John Wiley & Sons, Ltd. 相似文献
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140.
A switched op amp with a fast common mode feedback (CMFB) circuit is presented. The proposed fully differential two stage amplifier needs CMFB only for the second stage, and thus a fast and simple passive CMFB circuit may be used. The amplifier is capable of 1 V operation and has no limitation on the maximum supply voltage 相似文献