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31.
Measurement of labile Cu in soil using stable isotope dilution and isotope ratio analysis by ICP-MS 总被引:1,自引:0,他引:1
Isotope dilution is a useful technique to measure the labile metal pool, which is the amount of metal in soil in rapid equilibrium (<7 days) with the soil solution. This is normally performed by equilibrating soil with a metal isotope, and sampling the labile metal pool by using an extraction (E value), or by growing plants (L value). For Cu, this procedure is problematic for E values, and impossible for L values, due to the short half-life of the 64Cu radioisotope (12.4 h), which makes access and handling very difficult. We therefore developed a technique using enriched 65Cu stable isotope and measurement of 63Cu/65Cu ratios by quadrupole inductively coupled plasma mass spectrometry (ICP-MS) to measure labile pools of Cu in soils using E value techniques. Mass spectral interferences in detection of 63Cu/65Cu ratios in soil extracts were found to be minimal. Isotope ratios determined by quadrupole ICP-MS compared well to those determined by high-resolution (magnetic sector) ICP-MS. E values determined using the stable isotope technique compared well to those determined using the radioisotope for both uncontaminated and Cu-contaminated soils. 相似文献
32.
Fuentes-Cabrera M Nicholson DM Sumpter BG Widom M 《The Journal of chemical physics》2005,123(12):124713
We investigate the possibility of tailoring the electronic properties of isoreticular metal-organic materials by replacing the metal atom in the metal-organic cluster and by doping. The electronic structure of M-IRMOF1, where IRMOF1 stands for isoreticular metal-organic framework 1 and M = Be, Mg, Ca, Zn, and Cd, was examined using density-functional theory. The results show that these materials have similar band gaps (ca. 3.5 eV) and a conduction band that is split into two bands, the lower of which has a width that varies with metal substitution. This variation prompted us to investigate whether doping with Al or Li could be used to tailor the electronic properties of the Zn-IRMOF1 and Be-IRMOF1 materials. It is shown that replacing one metal atom with Al can effectively be used to create IRMOFs with different metallic properties. On the other hand, adding Li produces structural changes that render this approach less suitable. 相似文献
33.
Cellulose synthesis in maize: isolation and expression analysis of the cellulose synthase (CesA) gene family 总被引:7,自引:0,他引:7
Laura Appenzeller Monika Doblin Roberto Barreiro Haiyin Wang Xiaomu Niu Krishna Kollipara Lori Carrigan Dwight Tomes Mike Chapman Kanwarpal S. Dhugga 《Cellulose (London, England)》2004,11(3-4):287-299
Stalk lodging in maize results in significant yield losses. We have determined that cellulose per unit length of the stalk is the primary determinant of internodal strength. An increase in cellulose concentration in the wall might allow simultaneous improvements in stalk strength and harvest index. Cellulose formation in plants can be perturbed by mutations in the genes involved in cellulose synthesis, post-synthetic cellulose alteration or deposition, N-glycosylation, and some other genes with as yet unknown functions. We have isolated 12 members of the cellulose synthase (CesA) gene family from maize. The genes involved in primary wall formation appear to have duplicated relatively independently in dicots and monocots. The deduced amino acid sequences of three of the maize genes, ZmCesA10–12, cluster with the Arabidopsis CesA sequences that have been shown to be involved in secondary wall formation. Based on their expression patterns across multiple tissues, these three genes appear to be coordinately expressed. The remaining genes show overlapping expression to varying degrees with ZmCesA1, 7, and 8 forming one group, ZmCesA3 and 5 a second group, and ZmCesA2 and 6 exhibiting independent expression of any other gene. This suggests that the varying levels of coexpression may just be incidental except in the case of ZmCesA10–12, which may interact with each other to form a functional enzyme complex. Isolation of the expressed CesA genes from maize and their association with primary or secondary wall formation has made it possible to test their respective roles in cellulose synthesis through mutational genetics or transgenic approaches. This information would be useful in improving stalk strength. 相似文献
34.
Erlanson DA McDowell RS He MM Randal M Simmons RL Kung J Waight A Hansen SK 《Journal of the American Chemical Society》2003,125(19):5602-5603
Protein tyrosine phosphatases play important roles in many signaling cascades involved in human disease. The identification of druglike inhibitors for these targets is a major challenge, and the discovery of suitable phosphotyrosine (pY) mimetics remains one of the key difficulties. Here we describe an extension of tethering technology, "breakaway tethering", which is ideally suited for discovering such new chemical entities. The approach involves first irreversibly modifying a protein with an extender that contains both a masked thiol and a known pY mimetic. The extender is then cleaved to release the pY mimetic, unmasking the thiol. The resulting protein is screened against a library of disulfide-containing small molecule fragments; any molecules with inherent affinity for the pY binding site will preferentially form disulfides with the extender, allowing for their identification by mass spectrometry. The ability to start from a known substrate mimimizes perturbation of protein structure and increases the opportunity to probe the active site using tethering. We applied this approach to the anti-diabetic protein PTP1B to discover a pY mimetic which belongs to a new molecular class and which binds in a novel fashion. 相似文献
35.
Yiming Mo Yanfei Guan Pritha Verma Jiang Guo Mike E. Fortunato Zhaohong Lu Connor W. Coley Klavs F. Jensen 《Chemical science》2021,12(4):1469
With recent advances in the computer-aided synthesis planning (CASP) powered by data science and machine learning, modern CASP programs can rapidly identify thousands of potential pathways for a given target molecule. However, the lack of a holistic pathway evaluation mechanism makes it challenging to systematically prioritize strategic pathways except for using some simple heuristics. Herein, we introduce a data-driven approach to evaluate the relative strategic levels of retrosynthesis pathways using a dynamic tree-structured long short-term memory (tree-LSTM) model. We first curated a retrosynthesis pathway database, containing 238k patent-extracted pathways along with ∼55 M artificial pathways generated from an open-source CASP program, ASKCOS. The tree-LSTM model was trained to differentiate patent-extracted and artificial pathways with the same target molecule in order to learn the strategic relationship among single-step reactions within the patent-extracted pathways. The model achieved a top-1 ranking accuracy of 79.1% to recognize patent-extracted pathways. In addition, the trained tree-LSTM model learned to encode pathway-level information into a representative latent vector, which can facilitate clustering similar pathways to help illustrate strategically diverse pathways generated from CASP programs.Tree-structured long short-term memory neural model learns to understand the retrosynthesis design strategies from patent-extracted retrosynthetic pathway data. 相似文献
36.
Kaige Sun Mike Tebyetekerwa Chao Wang Xianfen Wang Xiwang Zhang Xiu Song Zhao 《Advanced functional materials》2023,33(18):2213578
Capacitive deionization (CDI) is an emerging water desalination technology for removing different ionic species from water, which is based on electric charge compensation by these charged species. CDI is becoming popular because it is more energy-efficient and cost-effective than other technologies, such as reverse osmosis and distillation, specifically in dealing with brackish water having low or moderate salt concentrations. Over the past decade, the CDI research field has witnessed significant advances in the used electrode materials, cell architectures, and associated mechanisms for desalination applications. This review article first discusses ion storage/removal mechanisms in carbon and Faradaic materials aided by advanced in situ analysis techniques and computations. It then summarizes research progress toward electrode materials in terms of structure, surface chemistry, and composition. More still, it discusses CDI cell architectures by highlighting their different cell design concepts. Finally, current challenges and future research directions are summarized to provide guidelines for future CDI research. 相似文献
37.
The molecular conformations and packing of [(tBuCO2)3M2(mu-X)M2(O2CtBu)3], where M = Mo and W, and X = oxalate and perfluoroterephthalate, determined in the solid-state from powder X-ray diffraction analysis, reveal one-dimensional coordination polymers involving pivalate-oxygen to metal interactions (X = perfluoroterephthalate), and oxalate--as well as pivalate-oxygen to metal bonds (X = oxalate), and allows explanation of the unusual state-dependent chromic properties of these compounds. 相似文献
38.
Mike M.K BoysenThisbe K Lindhorst 《Tetrahedron》2003,59(22):3895-3898
Two new pathways to introduce carbohydrate derivatives into dendritic carbosilane structures were explored. Pathway one utilised alcoholysis of a chlorosilane with a protected hydroxyethyl glycoside resulting in Si-O linkages. Pathway two proceeds via a hydrosilylation reaction of a protected allyl glycoside with a carbosilane containing Si-H end groups in the presence of a platinum catalyst, thus leading to Si-C linked structures. 相似文献
39.
Hodgson P Lloyd-Jones GC Murray M Peakman TM Woodward RL 《Chemistry (Weinheim an der Bergstrasse, Germany)》2000,6(24):4451-4460
The C2-symmetric ("[DL]") and achiral ("[meso]") diastereoisomers of the hydrogen iodide salt of 1,8-bis-(N-benzyl-N-methylamino)naphthalene ([2H]-[I] ) interconvert in solution. Direct interconversion of the diastereoisomers of [2H]+ must involve hydrogen bond fission (to give "[nonHB-2H+]") and rotation-inversion of the non-protonated nitrogen centre. The global activation parameters (deltaH++ and deltaS++) for diastereoisomer interconversion in [D7]DMF have been determined from rate data obtained by temperature-drop and magnetisation-transfer 13C NMR spectroscopy over a temperature range of 170 degrees C. The process is found to have a high entropy of activation in both directions (deltaS++=163(+/-4) and 169(+/-4) JK(-1)mol(-1)) and this is suggested to arise through hydrogen bonding of the ammonium centre in [nonHB-2H+] with the solvent ([D7]DMF). Comparison of the enthalpy of activation (deltaH++) with that earlier found for diastereoisomer interconversion of the free-base form 2 suggests that the intramolecular hydrogen bond in [2H]+ is roughly equal in enthalpic strength (deltaH) with that made with the solvent ([D7]DMF) in the non-hydrogen-bonded intermediate [nonHB-2H+]. As such, the hydrogen bonding in [2H]+ may be considered as predominantly an entropically driven process, without any unusual enthalpic strength. 相似文献
40.
Ruthenium(II) complexes of monodonor ligands: efficient reagents for asymmetric ketone hydrogenation
Xu YA Clarkson GC Docherty G North CL Woodward G Wills M 《The Journal of organic chemistry》2005,70(20):8079-8087
[Chemical reaction: See text] A series of BINOL-derived ligands have been prepared and incorporated into ruthenium(II) complexes containing a diamine ligand. The complexes have proven to be excellent catalysts for the asymmetric hydrogenation of ketones, giving reduction products with enantiomeric excesses of up to 99%. 相似文献