Performance Analysis of System with Micro- and Macrodiversity Reception in Correlated Gamma Shadowed Rician Fading Channels

In this paper, the performance of wireless system employing microdiversity to mitigate the effects of short-term fading and macrodiversity to reduce long-term fading (shadowing) effects is studied. The system model assumes implementation of maximal-ratio combining (MRC) at the microlevel and selection combining (SC) at the macrolevel. The received signal envelope follows a Rician distribution and it also suffers gamma shadowing. Novel expressions for the probability density function (PDF), cumulative distribution function (CDF), and moment-generating function (MGF) of the output signal-to-noise ratio (SNR) are obtained. Several useful performance criteria, such as the moments of the output SNR and outage probability are analytically derived. Moreover, the average bit error probability (ABEP) for noncoherent binary differential phase-shift keying (BDPSK) is calculated using the MGF based approach while the ABEP for coherent binary phase-shift keying (BPSK) is studied by averaging the conditional bit error probability over the PDF. Numerical results are graphically presented to show the effects of various system parameters to the system performance, as well as the enhancement due to use of the combination of micro- and macrodiversity. Some of numerical results are complemented by equivalent computer simulated results which validate the accuracy of the proposed analysis. The agreement between the Rician-gamma and Rician-lognormal fading model is also established.     

Outage analysis of selection diversity over Rayleigh fading channels with multiple co-channel interferers

In this paper an approach to the performance analysis of signal-to-interference (SIR) based selection combining (SC) operating over the Rayleigh fading channels experiencing an arbitrary number of multiple, Rayleigh co-channel interferers is presented. We have presented a general analysis of multibranch SC where each branch experiences an arbitrary number of multiple equal power co-channel interferers. Useful closed form expressions are derived for the probability density function (PDF) and cumulative distribution function (CDF) at the output of the combiner. Also an outage analysis is performed in order to show the effects of the number of multiple interferers, diversity order and input SIR unbalance to the system performances.     

Second‐Order Statistics of System with Microdiversity and Macrodiversity Reception in Gamma‐Shadowed Rician Fading Channels

In this letter, a wireless communication system with microdiversity and macrodiversity reception in gamma‐shadowed Rician fading channels is considered. Exact and rapidly converging infinite‐series expressions for the average level crossing rate and average fade duration at the output of the system are provided. Numerical results are presented graphically to illustrate the proposed mathematical analysis and to examine the effects of the system's parameters on the quantities considered.     

Biological Activity of Amidino-Substituted Imidazo [4,5-b]pyridines

A series of cyano- and amidino-substituted imidazo[4,5-b]pyridines were synthesized using standard methods of organic synthesis, and their biological activity was evaluated. Biological evaluation included in vitro assessment of antiproliferative effects on a diverse selection of human cancer cell lines, antibacterial activity against chosen Gram-positive and Gram-negative bacterial strains, and antiviral activity on a broad panel of DNA and RNA viruses. The most pronounced antiproliferative activity was observed for compound 10, which contained an unsubstituted amidino group, and compound 14, which contained a 2-imidazolinyl amidino group; both displayed selective and strong activity in sub-micromolar inhibitory concentration range against colon carcinoma (IC₅₀ 0.4 and 0.7 μM, respectively). All tested compounds lacked antibacterial activity, with the exception of compound 14, which showed moderate activity against E. coli (MIC 32 μM). Bromo-substituted derivative 7, which contained an unsubstituted phenyl ring (EC₅₀ 21 μM), and para-cyano-substituted derivative 17 (EC₅₀ 58 μM) showed selective but moderate activity against respiratory syncytial virus (RSV).     

Deoxyribozyme-based logic gates

We report herein a set of deoxyribozyme-based logic gates capable of generating any Boolean function. We construct basic NOT and AND gates, followed by the more complex XOR gate. These gates were constructed through a modular design that combines molecular beacon stem-loops with hammerhead-type deoxyribozymes. Importantly, as the gates have oligonucleotides as both inputs and output, they open the possibility of communication between various computation elements in solution. The operation of these gates is conveniently connected to a fluorescent readout.     

Individual and joint influence of second- and third-order dispersion on the transmission quality in the presence of coherent interference

The shape of a resulting pulse (coherent interference superimposed to Gaussian pulse) along the linear optical fiber is determined by using attained analytical expressions. These analytical expressions enable the investigation of the influence of arbitrary dispersion order on pulse propagation. Individual and joint influence of second- and third-order dispersion on the transmission quality is examined in this paper. Pulse shape, eye diagram and bit error rate (BER) are used to represent in the best manner the above-mentioned influences.     

The Extended Hadamard Transform: Sensitivity-Enhanced NMR Experiments Among Labile and Non-Labile 1Hs of SARS-CoV-2-derived RNAs

Hadamard encoded saturation transfer can significantly improve the efficiency of NOE-based NMR correlations from labile protons in proteins, glycans and RNAs, increasing the sensitivity of cross-peaks by an order of magnitude and shortening experimental times by ≥100-fold. These schemes, however, fail when tackling correlations within a pool of labile protons – for instance imino-imino correlations in RNAs or amide-amide correlations in proteins. Here we analyze the origin of the artifacts appearing in these experiments and propose a way to obtain artifact-free correlations both within the labile pool as well as between labile and non-labile ¹Hs, while still enjoying the gains arising from Hadamard encoding and solvent repolarizations. The principles required for implementing what we define as the extended Hadamard scheme are derived, and its clean, artifact-free, sensitivity-enhancing performance is demonstrated on RNA fragments derived from the SARS-CoV-2 genome. Sensitivity gains per unit time approaching an order of magnitude are then achieved in both imino-imino and imino-amino/aromatic protons 2D correlations; similar artifact-free sensitivity gains can be observed when carrying out extended Hadamard encodings of 3D NOESY/HSQC-type experiments. The resulting spectra reveal significantly more correlations than their conventionally acquired counterparts, which can support the spectral assignment and secondary structure determination of structured RNA elements.     

Characterization of transverse channel concentration profiles obtainable with a class of microfluidic networks

We analyze mathematically a previously reported class of passive microfluidic mixing networks. The networks produce nonhomogeneous concentrations in the output channel, resulting in diverse concentration profiles. We formally prove that all profiles obtainable with this class of networks can be described as polynomials of degree no higher than the number of input channels less one. We derive explicit formulas for the calculation of resultant output concentration profiles and conversely for the calculation of input concentrations needed to obtain set output profiles.     

Counterdiabatic suppression of background state population in resonance leaking by controlling intermediate branching

The counterdiabatic principle [M. Demirplak and S. A. Rice, J. Phys. Chem. A 107, 9937 (2003)] is used in a pragmatic way to formulate a practical control strategy for perturbed population transfer. Interpreting the appearance of population in undesirable intruder or background states as phenomenological consequences of diabatic perturbations, such branching is suppressed as soon as it arises. By invoking a penalty term that is sensitive to any transitional population in undesirable levels, a correction field is created which effectively prevents diabatic behavior. This strategy is applied to the control of background state population in multiphoton excitations. For a model five-level system we show that leaking of a resonant three-photon transition to a background state can readily be suppressed by simple correction fields obtained from our intermediate-branching driven implementation of counterdiabatic control.     

Influence of imperfect carrier recovery on satellite QPSK communication system performance

The purpose of this paper is to provide the theoretical approach for determining the bit error probability in detecting a coherent quaternary phase-shift-keyed signal transmitted over a soft-limited channel in the presence of the uplink and downlink noise, as well as the noisy carrier reference signal. The uplink noise is considered in the specific way through the envelope variations and the frequency offset of the signal remitted by the satellite station having influence on the variations of the phase-locked loop parameters in the receiving ground station, consequently on the probability density function of the phase error, i.e. the average bit error probability. The downlink noise is also taken into consideration. The determined results are based on the non-linear phase-locked loop model with primary emphasis on the degradations in the system performance produced by the imperfect carrier signal extraction. Copyright © 1999 John Wiley & Sons, Ltd.