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901.
Mahmood M. S. Abdullah Abdelrahman O. Ezzat Hamad A. Al-Lohedan Ali Aldalbahi Ayman M. Atta 《Molecules (Basel, Switzerland)》2022,27(10)
This work aimed to use abietic acid (AA), as a widely available natural product, as a precursor for the synthesis of two new amphiphilic ionic liquids (AILs) and apply them as effective demulsifiers for water-in-crude oil (W/O) emulsions. AA was esterified using tetraethylene glycol (TEG) in the presence of p-toluene sulfonic acid (PTSA) as a catalyst obtaining the corresponding ester (AATG). AATG was reacted with 1-vinylimidazole (VIM) throughout the Diels–Alder reaction, forming the corresponding adduct (ATI). Following this, ATI was quaternized using alkyl iodides, ethyl iodide (EI), and hexyl iodide (HI) to obtain the corresponding AILs, ATEI-IL, and ATHI-IL, respectively. The chemical structure, surface activity, thermal stability, and relative solubility number (RSN) were investigated using different techniques. The efficiency of ATEI-IL and ATHI-IL to demulsify W/O emulsions in different crude oil: brine volumetric ratios were evaluated. ATEI-IL and ATHI-IL achieved promising results as demulsifiers. Their demulsification efficiency increased as the brine ratios decreased where their efficiency reached 100% at the crude oil: brine ratio (90:10), even at low concentrations. 相似文献
902.
Raisul Awal Mahmood Anamul Hasan Mohammed Rahmatullah Alok K. Paul Rownak Jahan Khoshnur Jannat Tohmina Afroze Bondhon Tooba Mahboob Veeranoot Nissapatorn Maria de Lourdes Pereira Tridib K. Paul Ommay Hany Rumi Christophe Wiart Polrat Wilairatana 《Molecules (Basel, Switzerland)》2022,27(15)
COVID-19, caused by the coronavirus SARS-CoV-2, emerged in late December 2019 in Wuhan, China. As of 8 April 2022, the virus has caused a global pandemic, resulting in 494,587,638 infections leading to 6,170,283 deaths around the world. Although several vaccines have received emergency authorization from USA and UK drug authorities and two more in Russia and China, it is too early to comment on the prolonged effectiveness of the vaccines, their availability, and affordability for the developing countries of the world, and the daunting task to vaccinate 7 billion people of the world with two doses of the vaccine with additional booster doses. As a result, it is still worthwhile to search for drugs and several promising leads have been found, mainly through in silico studies. In this study, we have examined the binding energies of several alkaloids and anthocyanin derivatives from the Solanaceae family, a family which contains common consumable vegetables and fruit items such as eggplant, pepper, and tomatoes. Our study demonstrates that Solanaceae family alkaloids such as incanumine and solaradixine, as well as anthocyanins and anthocyanidins, have very high predicted binding energies for the 3C-like protease of SARS-CoV-2 (also known as Mpro). Since Mpro is vital for SARS-CoV-2 replication, the compounds merit potential for further antiviral research towards the objective of obtaining affordable drugs. 相似文献
903.
Fawad Mahmood Jamshaid Ali Khan Mater H. Mahnashi Muhammad Saeed Jan Muhammad Aamir Javed Umer Rashid Abdul Sadiq Syed Shams ul Hassan Simona Bungau 《Molecules (Basel, Switzerland)》2022,27(13)
In the current study, a series of new (2S,3S)-2-(4-isopropylbenzyl)-2-methyl-4-nitro-3-phenylbutanals (FM1-6) with their corresponding carboxylic acid analogues (FM7-12) has been synthesized. Initially, the aldehydic derivatives were isolated in the diastereomeric form, and the structures were confirmed with NMR, MS and elemental analysis. Based on the encouraging results in in vitro COX 1/2, 5-LOX and antioxidant assays, we oxidized the compounds and obtained the pure single (major) diastereomer for activities. Among all the compounds, FM4, FM10 and FM12 were the leading compounds based on their potent IC50 values. The IC50 values of compounds FM4, FM10 and FM12 were 0.74, 0.69 and 0.18 µM, respectively, in COX-2 assay. Similarly, the IC50 values of these three compounds were also dominant in COX-1 assay. In 5-LOX assay, the majority of our compounds were potent inhibitors of the enzyme. Based on the potency and safety profiles, FM10 and FM12 were subjected to the in vivo experiments. The compounds FM10 and FM12 were observed with encouraging results in in vivo analgesic and anti-inflammatory models. The molecular docking studies of the selected compounds show binding interactions in the minimized pocked of the target proteins. It is obvious from the overall results that FM10 and FM12 are potent analgesic and anti-inflammatory agents. 相似文献
904.
Shima Majidansari Negin Vahedi Mahmood Rekabgardan Camellia Ganjoury Najmeh Najmoddin Mohammad Tabatabaei Faraz Sigaroodi Paniz Naraghi-Bagherpour Seyed Amir Ali Taheri Mohammad-Mehdi Khani 《先进技术聚合物》2023,34(2):740-747
Cardiovascular diseases have always been one of the main causes of death worldwide and eventually one of the major medical concerns. Tissue engineering is promising strategies of treating cardiovascular, which can be an effective approach with the design of appropriate scaffold. In this study, to develop engineering basement membrane for endothelial differentiation with good cell attachment, we produced polycaprolactone (PCL)/poly (glycerol sebacate) (PGS)/gelatin nanofibrous scaffold via electrospinning. Attenuated total reflectance-Fourier transform infrared and the proton nuclear magnetic resonance results confirmed the chemical structure of synthesized PGS. Scanning electron microscope images of the electrospun scaffold revealed that the nanofibers are smooth, continues and uniform. Moreover, due to the presence of hydrophilic functional groups in the scaffold, the contact angle is in the appropriate range for cell adhesion especially endothelial cells. The elastic modulus and ultimate tensile stress of electrospun scaffold were calculated 1.32 ± 0.27 MPa and 1.23 ± 0.18 MPa respectively. Quantitative polymerase chain reaction was performed for evaluation of endothelial differentiation of mesenchymal stem cells cultured on standard plate and fibrous scaffold under chemical stimulation with growth factor. Specific endothelial gene expression results postulated that our modified scaffold could support and significantly promote endothelial differentiation of MSCs. 相似文献
905.
906.
An efficient acid-catalyzed synthesis of 1,5-diaryl-3-(arylamino)-1H-pyrrol-2(5H)-ones is reported using novel N-sulfonic acid modified poly (styrene-diethylenetriamine) through three-component reaction between aldehyde, amine, and ethyl pyruvate in high yields and short times. This heterogeneous solid catalyst is produced by reacting amine-modified chloromethyl polystyrene with neat chlorosulfonic acid. The structure of the synthesized catalyst was examined with Fourier transform-infrared spectroscopy (FT-IR), X-ray diffraction (XRD), dynamic light scattering (DLS), thermogravimetric analysis (TGA), differential thermal analysis (DTA), scanning electron micrograph (SEM), Brunauer–Emmett–Teller (BET), energy dispersive spectroscopy (EDS), and elemental analyses. The heterogeneous catalyst has many advantages, including an easy work-up procedure, a high product yield, and the capability to be easily regenerated and reused for at least five cycles without losing its activity. 相似文献
907.
908.
909.
Abdul Mannan Mohammad S. Obaidat Khalid Mahmood Aftab Ahmad Rodina Ahmad 《International Journal of Communication Systems》2023,36(5):e5423
The unmanned aerial vehicle network communication includes all points of interest during the coverage path planning. Coverage path planning in such networks is crucial for many applications, such as surveying, monitoring, and disaster management. Since the coverage path planning belongs to NP-hard issues, researchers in this domain are constantly looking for optimal solutions for this task. The speed, direction, altitude, environmental variations, and obstacles make coverage path planning more difficult. Researchers have proposed numerous algorithms regarding coverage path planning. In this study, we examined and discussed existing state-of-the-art coverage path planning algorithms. We divided the existing techniques into two core categories: Classical and reinforcement learning. The classical algorithms are further divided into subcategories due to the availability of considerable variations in this category. For each algorithm in both types, we examined the issues of mobility, altitude, and characteristics of known and unknown environments. We also discuss the optimality of different algorithms. At the end of each section, we discuss the existing research gaps and provide future insights to overcome those gaps. 相似文献
910.
Dr. Zafar Mahmood Jia He Shuqing Cai Zhanxiang Yuan Hui Liang Qian Chen Prof. Yanping Huo Prof. Burkhard König Prof. Shaomin Ji 《Chemistry (Weinheim an der Bergstrasse, Germany)》2023,29(1):e202202677
Tuning the redox potential of commonly available photocatalyst to improve the catalytic performance or expand its scope for challenging synthetic conversions is an ongoing demand in synthetic chemistry. Herein, the excited state properties and redox potential of commercially available [Ru(bpy)3]2+ photocatalyst were tuned by modifying the structure of the bipyridine ligands with electron-donating/withdrawing units. The visible-light-mediated photoredox phosphorylation of tertiary aliphatic amines was demonstrated under mild conditions. A series of cross-dehydrogenative coupling reactions were performed employing the RuII complexes as photocatalyst giving the corresponding α-aminophosphinoxides and α-aminophosphonates via carbon-phosphorus (C−P) bond formation. 相似文献