Electrocatalysis of Fe-N-C Bonds Driving Reliable Interphase and Fast Kinetics for Phosphorus Anode in Sodium-Ion Batteries

Phosphorus exhibits high capacity and low redox potential, making it a promising anode material for future sodium-ion batteries. However, its practical applications are confined by poor durability and sluggish kinetics. Herein, an innovative in-situ electrochemically self-driven strategy is presented to embed phosphorus nanocrystal (≈10 nm) into a Fe-N-C-rich 3D carbon framework (P/Fe-N-C). This strategy enables rapid and high-capacity sodium ion storage. Through a combination of experimental assistance and theoretical calculations, a novel synergistic catalytic mechanism of Fe-N-C is reasonably proposed. In detail, the electrochemical formation of Fe-N-C catalytic sites facilitates the release of fluorine in ester-based electrolyte, inducing Na⁺-conducting-enhanced solid-electrolyte interphase. Furthermore, it also effectively induces the dissociation energy of the P-P bond and promotes the reaction kinetics of P anode. As a result, the unconventional P/Fe-N-C anode demonstrates outstanding rate-capability (267 mAh g⁻¹ at 100 A g⁻¹) and cycling stability (72%, 10 000 cycles). Notably, the assembled pouch cell achieves high-energy density of 220 Wh kg⁻¹.     

Macrophage Membrane-Coated Nanoparticles Sensitize Glioblastoma to Radiation by Suppressing Proneural–Mesenchymal Transformation in Glioma Stem Cells

Radiotherapy is identified as a crucial treatment for patients with glioblastoma, but recurrence is inevitable. The efficacy of radiotherapy is severely hampered partially due to the tumor evolution. Growing evidence suggests that proneural glioma stem cells can acquire mesenchymal features coupled with increased radioresistance. Thus, a better understanding of mechanisms underlying tumor subclonal evolution may develop new strategies. Herein, data highlighting a positive correlation between the accumulation of macrophage in the glioblastoma microenvironment after irradiation and mesenchymal transdifferentiation in glioblastoma are presented. Mechanistically, elevated production of inflammatory cytokines released by macrophages promotes mesenchymal transition in an NF-κB-dependent manner. Hence, rationally designed macrophage membrane-coated porous mesoporous silica nanoparticles (MMNs) in which therapeutic anti-NF-κB peptides are loaded for enhancing radiotherapy of glioblastoma are constructed. The combination of MMNs and fractionated irradiation results in the blockage of tumor evolution and therapy resistance in glioblastoma-bearing mice. Intriguingly, the macrophage invasion across the blood-brain barrier is inhibited competitively by MMNs, suggesting that these nanoparticles can fundamentally halt the evolution of radioresistant clones. Taken together, the biomimetic MMNs represent a promising strategy that prevents mesenchymal transition and improves therapeutic response to irradiation as well as overall survival in patients with glioblastoma.     

Bacteria-Responsive Self-Assembly of Antimicrobial Peptide Nanonets for Trap-and-Kill of Antibiotic-Resistant Strains

Bacterial trapping using nanonets is a ubiquitous immune defense mechanism against infectious microbes. These nanonets can entrap microbial cells, effectively arresting their dissemination and rendering them more vulnerable to locally secreted microbicides. Inspired by this evolutionarily conserved anti-infective strategy, a series of 15 to 16 residue-long synthetic β-hairpin peptides is herein constructed with the ability to self-assemble into nanonets in response to the presence of bacteria, enabling spatiotemporal control over microbial killing. Using amyloid-specific K114 assay and confocal microscopy, the membrane components lipoteichoic acid and lipopolysaccharide are shown to play a major role in determining the amyloid-nucleating capacity as triggered by Gram-positive and Gram-negative bacteria respectively. These nanonets displayed both trapping and killing functionalities, hence offering a direct improvement from the trap-only biomimetics in literature. By substituting a single turn residue of the non-amyloidogenic BTT1 peptide, the nanonet-forming BTT1-3A analog is produced with comparable antimicrobial potency. With the same sequence manipulation approach, BTT2-4A analog modified from BTT2 peptide showed improved antimicrobial potency against colistin-resistant clinical isolates. The peptide nanonets also demonstrated robust stability against proteolytic degradation, and promising in vivo efficacy and biosafety profile. Overall, these bacteria-responsive peptide nanonets are promising clinical anti-infective alternatives for circumventing antibiotic resistance.     

A NIR-II AIEgen-Based Supramolecular Nanodot for Peroxynitrite-Potentiated Mild-Temperature Photothermal Therapy of Hepatocellular Carcinoma

Compared to conventional photothermal therapy (PTT) which requires hyperthermia higher than 50 °C, mild-temperature PTT is a more promising antitumor strategy with much lower phototoxicity to neighboring normal tissues. However, the therapeutic efficacy of mild-temperature PTT is always restricted by the thermoresistance of cancer cells. To address this issue, a supramolecular drug nanocarrier is fabricated to co-deliver nitric oxide (NO) and photothermal agent DCTBT with NIR-II aggregation-induced emission (AIE) characteristic for mild-temperature PTT. NO can be effectively released from the nanocarriers in intracellular reductive environment and DCTBT is capable of simultaneously producing reactive oxygen species (ROS) and hyperthermia upon 808 nm laser irradiation. The generated ROS can further react with NO to produce peroxynitrite (ONOOˉ) bearing strong oxidization and nitration capability. ONOOˉ can inhibit the expression of heat shock proteins (HSP) to reduce the thermoresistance of cancer cells, which is necessary to achieve excellent therapeutic efficacy of DCTBT-based PTT at mild temperature (<50 °C). The antitumor performance of ONOOˉ-potentiated mild-temperature PTT is validated on subcutaneous and orthotopic hepatocellular carcinoma (HCC) models. This research puts forward an innovative strategy to overcome thermoresistance for mild-temperature PTT, which provides new inspirations to explore ONOOˉ-sensitized tumor therapy strategies.     

声透镜指向性换能器研究

该文利用声学透镜使声波能量聚焦,实现小尺寸换能器窄波束声辐射。利用有限元方法分别建立了单凹面声透镜及双凹面声透镜仿真模型,优化了声透镜结构参数,设计并制作了双凹面声透镜指向性换能器,并在消声水池内对换能器样机和声透镜进行了性能测试。换能器样机辐射面积直径?120 mm,设置声透镜后,提高发送电压响应级4 dB,发射指向性-3 dB波束开角由76°变为约30°(@10 kHz),与仿真计算结果相符。实验结果表明,声透镜有效减小了换能器发射波束宽度,提高了换能器主瓣发送电压响应,验证了双凹面声透镜对优化换能器指向性的效果。     

人工噪声辅助的多用户安全传输方法

针对传统人工噪声辅助的安全传输方法无法适用于发射天线数等于接收天线数的多用户(Multiuser, MU)多输入多输出(Multiple-Input Multiple-Output, MIMO)系统的问题,提出了一种人工噪声辅助的多用户安全传输新方法。通过合理设计人工噪声与预编码矩阵,该方法可在同时满足所有用户传输需求的基础上,显著提升发射天线数等于接收天线数的MU-MIMO系统的安全性。同时,针对提出的方法进行了检测算法与平均保密速率的推导与分析。理论分析与仿真结果表明,所提方法可有效提升无线通信系统的安全性,在信噪比为20 dB时,该方法较传统方法的平均保密速率提升达到120%。     

基于钛相变边缘传感器的超导单光子探测器特性

研究了基于钛TES的超导单光子探测器的特性,器件尺寸范围为5 μm×5 μm到20 μm×20 μm,集成光学腔体后在1 550 nm波长实测的系统探测效率最高达到72%,最佳能量分辨率为0.26 eV。在此基础上,采用二流体模型提取了基于钛TES的超导单光子探测器的特性参数（包括温度灵敏度、电流灵敏度、热容等）,并模拟计算了基于钛TES的超导单光子探测器的响应时间和能量分辨率,与实验结果完全吻合。结果表明优化探测器尺寸和临界温度,可以同时达到高探测效率和高能量分辨率,实现光子数可分辨的高性能单光子探测器。     

Research on the Mechanical Properties of Magnetorheological Damping and the Performance of Microprobe Test Process

Journal of Electronic Testing - In order to control the stable and controllable loading of the wafer level microprobe test bench, the magnetorheological (MR) damper used in the existing research...     

A Low-Complexity Precoding Scheme for Downlink Massive MU-MIMO Systems with Low-Resolution DACs

In this paper, we investigate the problem of downlink precoding for the narrowband massive multi-user multiple-input multiple-output (MU-MIMO) system with low-resolution digital-to-analog converters (DACs). We introduce a low-complexity precoding scheme based on the alternating direction method of multipliers (ADMM) framework in this work. An efficient gradient descent (GD) algorithm with adaptive step-size determination mechanism (ASGD) is proposed to alleviate the computational complexity bottleneck of the inherent matrix inversion. Numerical results demonstrate that the ASGD precoder achieves an attractive trade-off between the performance and computational complexity compared with other counterparts.

     

5G 功放DPD 的FPGA 宽带实现及自动优化

5G 宽带功放数字预失真器(DPD)的FPGA 实现过程中,常遇到数字处理带宽不够和资源有限问题,对 此,文中提出一种基于双路并行数据流的数字预失真带宽扩展方法和基于Zynq Ultrascale+ MPSoC 的自动化模型优化 验证方法,可快速实现对5G 宽带功放线性化方案的优化。使用该并行处理结构的数字预失真器,克服了数字电路最 大时钟频率造成的对FPGA 线性化带宽的限制,使得数字预失真电路在每个时钟周期内可以处理更多的数据,不仅有 效地增加了数字处理带宽,而且降低了DPD 的功耗。然而,这种带宽增加以消耗更多硬件资源为代价,对此,文中同时 提出了对预失真非线性模型的在线自动优化方法,以简化非线性模型、降低DPD 的硬件资源开销。最后,在Zynq Ultrascale+ FPGA 实验平台上实现了具有两路并行数据处理的I-MSA 自优化数字预失真电路,采用100 MHz 的5G 新无 线电(NR)信号在2. 6 GHz 功率放大器上进行线性化实验验证,获得了满意的预失真性能,验证了所提方法的有效性。