REDUCING NONSELECTIVE PROTEIN ADSORPTION AND CELL ADHESION ON POLYACRYLONITRILE FILMS BY COPOLYMERIZATION OF ACRYLONITRILE WITH α-ALLYL GLUCOSIDE

In this work, the surface properties of novel sugar-containing polymers, α-allyl glucoside (AG)/acrylonitrile (AN)copolymers, were studied by contact angle, protein adsorption and cell adhesion measurements. It was found that the contactangle of the copolymer films decreased from 68° to 30° with the increase of AG content in the copolymer. The adsorptionamount of bovine serum albumin (BSA) and the adhesive macrophage onto the film surface also decreased significantly withincreasing α-allyl glucoside content from 0 to 42 wt% in the copolymer. These preliminary results reveal that both thehydrophilicity and the biocompatibility of polyacrylonitrile-based membranes could be improved by copolymerizing acrylonitrile with vinyl carbohydrates.     

Development of high-performance liquid chromatographic fingerprints for distinguishing Chinese Angelica from related umbelliferae herbs

A high-performance liquid chromatographic (HPLC) fingerprint of Chinese Angelica (CA) was developed basing on the consistent chromatograms of 40 CA samples (Angelica sinensis (Oliv.) Diels). The unique properties of this HPLC fingerprints were validated by analyzing 13 related herbs including 4 Japanese Angelicae Root samples (JA, A. acutiloba Kitagawa and A. acutiloba Kitagawa var. sugiyame Hikino), 6 Szechwan Lovage Rhizome samples (SL, Ligusticum chuanxiong Hort.) and 3 Cnidium Rhizome samples (CR, Cnidium officinale Makino). Both correlation coefficients of similarity in chromatograms and relative peak areas of characteristic compounds were calculated for quantitative expression of the HPLC fingerprints. The amount of senkyunolide A in CA was less than 30-fold of that in SL and CR samples, which was used as a chemical marker to distinguish them. JA was easily distinguished from CA, SL and CR based on either chromatographic patterns or the amount of coniferyl ferulate. No obvious difference between SL and CR chromatograms except the relative amount of some compounds, suggesting that SL and CR might have very close relationship in terms of chemotaxonomy. Ferulic acid and Z-ligustilide were unequivocally determined whilst senkyunolide I, senkyunolide H, coniferyl ferulate, senkyunolide A, butylphthalide, E-ligustilide, E-butylidenephthalide, Z-butylidenephthalide and levistolide A were tentatively identified in chromatograms based on their atmospheric pressure chemical ionization (APCI) MS data and the comparison of their UV spectra with those published in literatures.     

冠醚菁染料及其中间体的特征红外光谱

本文首次报道冠醚菁染料3,3’-二乙基-5,6,5’,6’-双骈-(15-冠-5)-硫碳菁碘盐(1)和3,3’-二乙甲基-5,6-骈-(15-冠-5)-硫碳菁碘盐(2)以及合成中间体:4’-溴5’-硝基-苯骈-15-冠-5(3),2.2’-二硝基-4,5,4’,5’-双骈-(15-冠-5)-二本基二硫化物(4),2-甲基-5,6-骈-(15-冠-5)-苯骈噻唑(5)和2-甲基-3-乙基-5,6-骈-(15-冠-5)-苯骄噻唑碘盐(6)的特征红外光谱图。     

两相滴定法研究2-乙基己基膦酸单2-乙基己基酯从盐酸介质中萃取钕(Ⅲ)的动力学

本文利用两相滴定法作为分析手段,用恒界面池搅拌法考察了多种因素对2-乙基己基膦酸单2-乙基己基酯(HEHEHP,HA)从盐酸介质中萃取Nd(Ⅲ)动力学的影响,从实验结果推论出萃取过程为界面化学反应控制型机理。     

氨基苯磺酸和氨基萘磺酸在反相离子对色谱和离子色谱中分离行为的比较

本文考察了氨基苯磺酸和氨基萘磺酸染料中间体在反相离子对色谱和离子色谱中的分离行为，结果表明一些异构体在反相色谱中的保留顺序与离子色谱中的顺序发生颠倒。静电作用力在离子色谱中对保留值的贡献比在反相离子对色谱中对保留值的贡献要大，而疏水作用力在反相离子对色谱中对保留值的贡献却较在离子色谱中对保留值的贡献要大。离子对色谱更有利于有机离子的分离分析。     

钇对2618合金组织及性能的影响

采用X射线，光学显微镜及扫描电镜等手段研究了2618合金中的组织与相结构，并研究了元素钆在2618合金中的存在形式及其对合金力学性能的影响。结果表明，微量钆元素在铝合金中是以化合物形式存在的；钆对合金中的铸态组织及Al9FeNi仃形态没有影响。由于微量钆的加入，降低了铜与镁在2618合金中的固溶量，减少了时效析出相A2CuMg数量，从而降低2618合金的室温强度帮在250℃的高温瞬时强度；但由于微量钆减少了铜与镁在2618合金中的扩散速度，延缓了时效机的粗化，并由于第二相数量的增多，因此提高了2618合金在250℃经100h高温热暴露后的高温瞬时强度。     

Localized molecular orbitals and the problem of quasi-aromaticity in trinuclear molybdenum cluster compounds with cores of the type [MO3(μ3-X)(μ-Y)3] (X, Y = O, S, n = 4; X = O, Y = Cl, n = 5)

Calculations of localized molecular orbitals (LMO) and their energy levels for the cluster cores [MO₃O₄]⁴⁺, [MO₃SO₃]⁴⁺, [MO₃OS₃]⁴⁺, [Mo₃S₄]⁴⁺ and [MO₃OCl₃]⁵⁺ have been made by the use of energy-localized CNDO/2-LMO. The results of these LMO calculations show that the six-membered closed and continuous π-conjugated systems around the [MO₃Y₃] rings, each of which is formed from three synergically connected three-centered two-electron π bonds, is the most significant feature of the electronic structure for the quasi-aromatic clusters [Mo₃(μ₃-Y)(μ-X)₃]⁴⁺ (X, Y = O, S), and the size and electronegativity of the bridging Y atoms exhibit significant effects on the degree of quasi-aromaticity of these cluster compounds. For the non-aromatic reference cluster [Mo₃OCl₃]⁵⁺, the results of our calculations also show a bonding scheme with only one isolated π bond, thus leading to the loss of quasi-aromaticity; and meanwhile, there is a pair of extra electrons localized on the apical molybdenum atom of the Mo₃ triangle, thus with three Mo---Mo single bonds.     

葡萄糖衍生的新型光学活性β－氨基醇的合成

首次报道了以Ｄ－葡萄糖为原料合成新型光学活性葡萄糖衍生类β－氨基醇化合物的新方法。目标化合物：（２Ｓ，３Ｓ）－甲基－２－脱氧－２－苯胺基－４，６－ｏ－苄叉基－α－Ｄ－吡喃阿卓糖苷（７）经各种分析测试手段证实。     

A nonlinear regression model applied to kinetic studies of ester hydrolysis with a surface acoustic wave sensor

A non-linear regression model was derived for the simultaneous determination of the rate constant in alkaline hydrolysis of esters and the initial concentration of esters based on the linear relationship between the frequency response of the surface acoustic wave sensor system and the conductivity of the solution. The model was tested theoretically and experimentally with the methyl-, ethyl-, and n-propyl-acetate systems. The corresponding rate constants estimated at 25 degrees C are 0.147, 0.103 and 0.0671 respectively.     

Diterpenes from the roots of Euphorbia kansui and their in vitro effects on the cell division of Xenopus (part 2)

Four new ingenane-type diterpenes, 3-O-(2,3-dimethylbutanoyl)-13-O-dodecanoyl-20-O-acetylingenol (1), 3-O-(2,3-dimethylbutanoyl)-13-O-dodecanoyl-20-deoxyingenol (2), 3-O-(2E,4Z-decadienoyl)-20-deoxyingenol (3), and 3-O-(2E,4E-decadienoyl)-20-deoxyingenol (4), two new jatrophane-type diterpenes, kansuinins D (9) and E (10), and four known ingenane-type diterpenes were isolated from the root of Euphorbia kansui. Their structures were elucidated by spectroscopic and chemical analysis, and individual Xenopus cells at the blastular stage were cultured with the diterpenes to test for biological activity. 20-Deoxyingenol diterpenes 3 and 4 induced the greatest cell cleavage arrest (0.5 micro g/ml of each compound resulted in >75% cleavage arrest), but cell cleavage inhibitory activity became weak when C-16 had an acyl residue. In contrast, the jatrophane diterpene kansuinin D (9) showed no activity.