Precise and continuous monitoring of biochemicals by biosensors assists to understand physiological functions for various diagnostics and therapeutic applications. For implanted biosensors, small size and flexibility are essential for minimizing tissue damage and achieving accurate detection. However, the active surface area of sensor decreases as the sensor becomes smaller,which will increase the impedance and decrease the signal to noise ratio, resulting in a poor detection limit. Taking advantages of local amplification effect, organic electrochemical transistors(OECTs) constitute promising candidates for high-sensitive monitoring. However, their detections in deep tissues are rarely reported. Herein, we report a family of implantable, fiber-shaped all-in-one OECTs based on carbon nanotube fibers for versatile biochemical detection including H_2O_2, glucose, dopamine and glutamate. These fiber-shaped OECTs demonstrated high sensitivity, dynamical stability in physiological environment and antiinterference capability. After implantation in mouse brain, 7-day dopamine monitoring in vivo was realized for the first time.These fiber-shaped OECTs could be great additions to the "life science" tool box and represent promising avenue for biomedical monitoring. 相似文献
In the recent publications (Gerace and Savona, Phys. Rev. A 89(R), 031803 2014; Zhou et al., Opt. Express 24, 17332 2016), the unconventional photon blockades are studied in a three-mode-second-order-nonlinearity system with linear coupling between the two low frequency modes. In this paper, the unconventional photon blockade is studied in a complementary case with linear coupling between the two high frequency modes. By solving the master equation in the steady-state limit and calculating the zerodelay- time second-order correlation function, a strong photon antibunching is found in this three-mode-second-order-nonlinearity system. The optimal antibunching conditions are derived and the numerical simulations confirm the optimal conditions. Our scheme can be used as a tunable single-photon source.
In living organisms, protein functions are constantly evolving over generations throughout the history. Through iterative rounds of genetic mutations and natural selection of fit phenotypes, protein functions have been gradually optimized. This process could be mimicked and even greatly accelerated in the laboratory, when the selection pressure is directly applied to biomolecules of interest, which forms the basis of a technique called directed evolution. The Nobel Prize in chemistry 2018 was awarded jointly to Frances Arnold, George Smith and Gregory P. Winter for their pioneering contributions to the development and applications of directed evolution. Here we briefly review the history of this technique and its impact on renewable energy and pharmaceutical industry. 相似文献
Foundations of Computational Mathematics - In this paper, we analyze several methods for approximating gradients of noisy functions using only function values. These methods include finite... 相似文献
One new diphenyl ether, diorcinol K (1), along with three known compounds, diorcinols D (2), F (3) and I (4) were isolated from the fermentation media of a marine-derived fungus Aspergillus sp. CUGB-F046 which was isolated from a sediment sample collected from the Bohai Sea, China. Their structures were elucidated by detailed spectroscopic methods. Compounds 1, 2 and 4 displayed significant antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus with MIC values of 3.125, 6.25 and 6.25 μg/mL, respectively. 相似文献