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81.
Teresa M. V. D. Pinho e Melo Clara S. B. Gomes Maria I. L. Soares Antanio M. d'A Rocha Gonsalves Jos A. Paixo Ana M. Beja Manuela Ramos Silva 《Journal of heterocyclic chemistry》2004,41(4):493-497
3‐Carbethoxy‐5‐phenyl‐5H,7H‐thiazolo[3,4‐c]oxazol‐4‐ium‐1‐olate was generated from (2R,4R)‐N‐ethoxyoxalyl‐2‐phenylthiazolidine‐4‐carboxylic acid and its reactivity studied. This münchnone showed low reactivity as dipole although from the reaction with dimethyl acetylenedicarboxylate the corresponding (3R)‐3‐phenyl‐17H,3H‐pyrrolo[1,2‐c]thiazole‐5,6,7‐tricarboxylate could be isolated. The thermolysis of (2R,4R)‐N‐ethoxyoxalyl‐2‐phenylthiazolidine‐4‐carboxylic acid in refluxing acetic anhydride led to the synthesis of N‐(1‐ethoxycarbonyl‐2‐phenylvinyl)‐2‐phenyl‐4‐thioxo‐1,3‐thiazolidine. The structure of methyl (2R,4R)‐N‐ethoxyoxalyl‐2‐phenylthiazoliddine‐4‐carboxylate was determined by X‐ray crystallography. 相似文献
82.
Carlton L 《Magnetic resonance in chemistry : MRC》2004,42(9):760-768
Rhodium-103 chemical shifts are reported for 62 compounds, namely [Rh(X)(PPh3)3] [X = Cl, N3, NCO, NCS, N(CN)2, NCBPh3, CNBPh3, CN] and derivatives formed by replacement of a phosphine by CO, xylyl isocyanide (XNC) and pyridine and/or by oxidative addition of H2 or O2 to give trans-[Rh(X)(PPh3)2(CO)] (delta in the range -816 to -368 ppm) trans-[Rh(X)(PPh3)2(XNC)] (delta -817 to -250 ppm), cis-[Rh(X)(PPh3)2(py)] (the trans isomer is formed with X = CN, CNBPh3) (delta -233 to 170 ppm), [Rh(X)(H)2(PPh3)3] (delta -611 to 119), trans-[Rh(X)(H)2(PPh3)2(py)] (delta -30 to 566 ppm), [Rh(X)(O2)(PPh3)3] (delta 1393 to 3273 ppm) and cis-[Rh(X)(O2)(PPh3)2(py)] (delta 1949 to 3374 ppm). For the majority of these compounds data were obtained from solutions in chloroform and in toluene at temperatures of 247 and 300 K; for [Rh(X)(PPh3)3] (delta -562 to -4 ppm) data are reported at a number of temperatures in the range 195-300 K for solutions in chloroform, toluene and dichloromethane and at 300 K for solutions in DMSO. The expected trend to lower delta(103Rh) with decreasing temperature (vibrational shielding) is observed for the dichloromethane data, but data from solutions {of [Rh(X)(PPh3)3]} in chloroform and toluene show a number of features which diverge from this pattern, i.e. shifts to higher delta are found to accompany a decrease in temperature, most noticeably where X = CN and Cl [on changing the solvent from dichloromethane to chloroform changes in delta(103Rh) of up to 172 ppm are observed]. These results are interpreted in terms of a hydrogen-bonded interaction with the solvent that is enhanced by the presence of a polarizable ligand (CN, Cl). With a ligand (O2CCF3) that is only weakly polarizable the solvent dependence of delta(103Rh) is minimal. 相似文献
83.
Rajendra J Baxendale M Dit Rap LG Rodger A 《Journal of the American Chemical Society》2004,126(36):11182-11188
Structures of carbon nanotube/ligand complexes were studied by flow linear dichroism (the differential absorption of light polarized parallel and perpendicular to the flow orientation direction) with the aim of establishing linear dichroism as a technique to study such systems. Anthracene, naphthalene, and DNA were chosen as ligands, and the potential for flow linear dichroism to probe ligands noncovalently (as well as covalently) bound to single-walled nanotubes is reported. Linear dichroism enables the determination of approximate orientations of the ligands on the carbon nanotubes. 相似文献
84.
McColl IH Blanch EW Hecht L Barron LD 《Journal of the American Chemical Society》2004,126(26):8181-8188
A vibrational Raman optical activity (ROA) study, supplemented by protein X-ray crystal structure data, of alpha-helices in polypeptides, proteins, and viruses has suggested that ROA bands in the extended amide III spectral region may be used to distinguish between two types of right-handed alpha-helix. One type, associated with a positive ROA band at approximately 1300 cm(-1), dominates in hydrophobic environments and appears to be unhydrated; the other, associated with a positive ROA band at approximately 1340 cm(-1), dominates in hydrophilic environments and appears to be hydrated. Evidence is presented to support the hypothesis that unhydrated alpha-helix corresponds to the canonical conformation alpha(c) and hydrated alpha-helix to a more open conformation alpha(o) stabilized by hydrogen bonding of a water molecule or a hydrophilic side chain to the peptide carbonyl. Alpha-helical poly(L-lysine) and poly(L-ornithine) in aqueous solution and poly(L-alanine) in dichloracetic acid display both bands, but alpha-helical poly(l-glutamic acid) in aqueous solution and poly(gamma-benzyl L-glutamate) in CHCl(3) display only the approximately 1340 cm(-1) band and so may exist purely as alpha(o) due to enhanced stabilization of this conformation by particular side chain characteristics. The ROA spectrum of poly(beta-benzyl L-aspartate) in CHCl(3) reveals that it exists in a single left-handed alpha-helical state more analogous to alpha(o) than to alpha(c). 相似文献
85.
Binamé J Meurice N Leherte L Glasgow J Fortier S Vercauteren DP 《Journal of chemical information and computer sciences》2004,44(4):1394-1401
In this paper, we propose a reduced representation of molecules of pharmacological interest based on their chemical functions. The proposed representations of the molecules are obtained by a topological analysis of their electron density maps at medium resolution, leading to graphs of critical points. The distribution of the different types of critical points are compared at various levels of resolution for a training set of 22 molecules in order to define the optimal resolution level leading to the best representation of the various chemical functions. The reduced representations can in the future be used for molecular similarity research and pharmacophore proposals. 相似文献
86.
87.
Lépine F Milot S Déziel E He J Rahme LG 《Journal of the American Society for Mass Spectrometry》2004,15(6):862-869
The opportunistic pathogen Pseudomonas aeruginosa produces a large array of 4-hydroxy-2-alkylquinolines (HAQs). These compounds were analyzed by LC/MS, using positive electrospray ionization, in the culture supernatant of strain PA14. Fifty-six HAQs and related compounds were detected and their [M + H](+) ions were further analyzed by collision induced dissociation (CID). These HAQs were grouped into five different series based on the presence of an hydrogen or hydroxyl group at the 3 position, an N-oxide group in place of the quinoline nitrogen, and an unsaturation on their alkyl side chain. Two new analogs of 3,4-dihydroxy-2 heptylquinoline, the Pseudomonas quinolone signal (PQS), were found with an alkyl chain longer by one and two methylene groups. Moreover, two additional series of compounds were identified in which a saturated or unsaturated alkyl side chain is located at the 3 position along with an hydroxyl group at the 3 position and a ketone at the 2 position. No HAQ N-oxides, nor any compounds from the latter two series, were detected in a pqsL mutant derivative of PA14, indicating that this gene is involved in the biosynthesis of these compounds. This work demonstrates the large repertoire of HAQ and HAQ-related compounds produced by P. aeruginosa, and provides insight into N-oxides biosynthesis and confirm the hypothesis that N-oxides are the precursors of compounds from Series 6 and 7. 相似文献
88.
Marcos Costa Souza William Pires Macedo Marcelo Campos M. Silva Guilherme Costa de O. Ramos Helmut G. Alt 《Phosphorus, sulfur, and silicon and the related elements》2013,188(6):1047-1054
This article describes an attractive and one-pot synthesis of the title compound by phosphorylation of just prepared N-substituted guanidines from cyanamide and the desired amine. The method allows a variety of N-substituents to hang on the final phosphoryl guanidine as a function of the wider availability of commercial simple amines. 相似文献
89.
Michèle Postel Félix Tomi Henri Li Kam Wah Laurence Mordenti Patricia Guillaume 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-4):453-457
Abstract Fe(NO)2XL and Fe(NO)X2L nitrosyl iron complexes, X = Cl, I, and L = HMPA, dppe, PPh3, activate molecular O2 to yield nitrato complexes. The phosphorous ligand is decisive for the oxidative power of these nitrates: with HMPA or dppe, oxygen transfer occurs only to phosphines. On going from HMPA to PPh3 the single nitrato complex obtained, Fe(NO)2X(OPPh3)2 selectively epoxidizes cyclohexene, and this is the first example of oxygen transfer from a nitrato ligand to an olefin. 相似文献
90.
Hidalgo A Jiménez LP Ramos LA Mroginski MA Jios JL Ulic SE Echeverría GA Piro OE Castellano E 《The journal of physical chemistry. A》2012,116(3):1110-1118
The (Z)-4,4,4-trifluoro-3-(2-hydroxyethylamino)-1-(2-hydroxyphenyl)-2-buten-1-one (C(12)H(12)F(3)NO(3)) compound was thoroughly studied by IR, Raman, UV-visible, and (13)C and (19)F NMR spectroscopies. The solid-state molecular structure was determined by X-ray diffraction methods. It crystallizes in the P2(1)/c space group with a = 12.1420(4) ?, b = 7.8210(3) ?, c = 13.8970(5) ?, β = 116.162(2)°, and Z = 4 molecules per unit cell. The molecule shows a nearly planar molecular skeleton, favored by intramolecular OH···O and NH···O bonds, which are arranged in the lattice as an OH···O bonded polymer coiled around crystallographic 2-fold screw-axes. The three postulated tautomers were evaluated using quantum chemical calculations. The lowest energy tautomer (I) calculated with density functional theory methods agrees with the observed crystal structure. The structural and conformational properties are discussed considering the effect of the intra- and intermolecular hydrogen bond interactions. 相似文献