成品率的预测准确度有多高

成品率预测是可制造性设计（DFM）的基础之，但它还远不止于此。IBM系统和技术群300mm半导体运营副总裁DanArmbrust说：“我们精确预测成品率的能力就是我们的经济模式。”Armbrust是SEMICON West 2007成品率论坛讨论DFM现状的三位参与者之一。与他共同参加讨论的是Synopsys公司DFM解决方案副总裁Anantha Sethuraman和Photronics公司的CTO Chris Progler。     

ContributionsSign-balanced covering matrices

A q × n array with entries from 0, 1,…,q − 1 is said to form a difference matrix if the vector difference (modulo q) of each pair of columns consists of a permutation of [0, 1,… q − 1]; this definition is inverted from the more standard one to be found, e.g., in Colbourn and de Launey (1996). The following idea generalizes this notion: Given an appropriate δ (-[−1, 1]^t, a λq × n array will be said to form a (t, q, λ, Δ) sign-balanced matrix if for each choice C₁, C₂,…, C_t of t columns and for each choice = (₁,…,_t) Δ of signs, the linear combination ∑_j=1^t _jC_j contains (mod q) each entry of [0, 1,…, q − 1] exactly λ times. We consider the following extremal problem in this paper: How large does the number k = k(n, t, q, λ, δ) of rows have to be so that for each choice of t columns and for each choice (₁, …, _t) of signs in δ, the linear combination ∑_j=1^t _jC_j contains each entry of [0, 1,…, q t- 1] at least λ times? We use probabilistic methods, in particular the Lovász local lemma and the Stein-Chen method of Poisson approximation to obtain general (logarithmic) upper bounds on the numbers k(n, t, q, λ, δ), and to provide Poisson approximations for the probability distribution of the number W of deficient sets of t columns, given a random array. It is proved, in addition, that arithmetic modulo q yields the smallest array - in a sense to be described.     

Synthesis of Surface-Modified Nanoparticles via Cycloaddition-Reactions

Summary. The surface modification of nanoparticles via azide/alkine-1,3-dipolar cycloaddition-reactions is described. Ligand exchange onto various nanoparticles was monitored by ¹H NMR spectroscopy and formed the basis for the attachment of ligands onto the nanoparticles and their subsequent modification by dipolar cycloaddition reactions. Nanoparticle-surfaces were monitored by binding onto self-assembled monolayers derivatized with matching supramolecular interactions after derivatization.     

Complex surfaces polarized by an ample and spanned line bundle of genus three

Let X be a complex connected projective nonsingular algebraic surface endowed with an ample line bundle L, which is spanned by its global sections. Pairs (X, L) as above, with sectional genus g(X, L)=1+(L·(K _X L))/2=3 are classified by means of the main techniques of adjunction theory.     

Solid-state interactions and drug release of teicoplanin in binary combinations with peracetylated α-, β-, and γ-cyclodextrins

Triacetyl α-cyclodextrin, triacetyl β-cyclodextrin and triacetyl γ-cyclodextrin were tested as possible hydrophobic carriers to prolong the release of hydrophilic teicoplanin (TCP). Physical–chemical characterization of individual components, drug-carrier physical mixtures at 0.5, 0.67 and 0.75 mass fraction of carrier, and the respective interaction products by kneading or evaporative crystallization under microwave irradiation was carried out using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). In vitro drug release in pH 7.4 phosphate buffer at 37 °C was determined by intrinsic dissolution rate (IDR) measurements on non disintegrating compressed discs. Solid-state interactions of TCP with triacetyl α-cyclodextrin by evaporative crystallization and kneading and with triacetyl β-cyclodextrin by evaporative crystallization (probably resulting in carrier amorphization) were demonstrated. The role of carrier hydrophobicity, carrier mass fraction and preparation method of solid drug-carrier combinations on solid-state drug-carrier interactions and slowing down of TCP release was assessed. Modulation of drug release can be achieved using TCP-triacetyl γ-cyclodextrin combinations at 0.5 mass fraction of carrier.     

Structural impacts on thallus and algal cell components of two lichen species in response to low-level air pollution in pacific northwest forests.

Lichens have long been regarded as bioindicators of air pollution, and structural studies typically have indicated negative impacts in highly polluted areas. In this research, Parmelia sulcata and Platismatia glauca were collected from one clean and two polluted sites in the Pacific Northwest forests of the United States to investigate the anatomical and ultrastructural responses of relatively resistant lichens to moderate air pollution. Light microscopy of polluted materials revealed only slight increases in the algal cell proportions of the thallus, and a decrease in the fungal cells of the medulla. Using transmission electron microscopy, increased lipid droplets in the cytoplasm and an increase in the cell wall thickness of the photobionts were found in the polluted lichens. These results were compared with physiological data in which the net carbon uptake did not show any significant differences; however, the total chlorophyll content was heightened in the polluted samples. The increased total chlorophyll content and the absence of any changes in the algal cell proportions of the polluted samples suggest that the photobionts possessed a higher chlorophyll content per unit volume of the photobiont at polluted sites. The results also indicate that lichens have altered their storage allocation in different cellular compartments. This may be a result of symbiotic readjustment(s) between the photobiont and the mycobiont. In comparison with the physiological results from these two species, these changes do not represent damaging effects by low-level air pollution.     

A comparative study of several HPLC methods for determining free amino acid profiles in honey

A study of the viability of three derivatizing reagents for obtaining amino acid profiles in honey through high performance liquid chromatography (HPLC) is presented. A method using diode array detection based on a reaction with diethyl ethoxymethylene malonate (DEMM) and two other methods using fluorescence detection based on derivatization with fluorenylmethyl chloroformate (FMOC-Cl) and 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) have been developed. The three methods yield detection limits close to the ppb level, but vary in relation to other analytical characteristics. The use of methyl chloroformate derivatives allows the profile to be obtained with the greatest sensitivity within a short time frame. On applying such methods to honey samples of diverse botanical origin, we observe that the proline values obtained are always lower than those found using the official spectrophotometric method, thereby underlining the advisability of using HPLC methods to reduce uncertainty in these results.