Correction: Click activated protodrugs against cancer increase the therapeutic potential of chemotherapy through local capture and activation

Correction for ‘Click activated protodrugs against cancer increase the therapeutic potential of chemotherapy through local capture and activation’ by Kui Wu et al., Chem. Sci., 2021, 12, 1259–1271, DOI: 10.1039/D0SC06099B.

The authors regret that the reference to the bond-breaking bioorthogonal chemistry, termed ‘click-to-release’ was omitted from the original article. In addition, we would like to include a reference describing the synthesis of compound 1, which is an intermediate to the protodrugs described in the original article. These references are listed below as ref. 1 and 2.The Royal Society of Chemistry apologizes for these errors and any consequent inconvenience to authors and readers.     

MTT法测定稀土离子对BEL-7402及K562细胞的毒性及增殖毒性

用MTT法测定稀土离子在不同浓度、不同培养液中,与BEL 7402和K562细胞作用不同时间,对细胞的毒性和增殖毒性。结果表明,在含10%小牛血清培养液中,仅个别稀土离子在较高浓度时对BEL 7402细胞增殖有较弱的抑制作用;对于K562细胞,稀土离子在低浓度时对细胞增殖即表现出较强的抑制作用(P<0.05)。当培养液不含小牛血清时,较低浓度的稀土离子即可抑制BEL 7402细胞的增殖(P<0 05)。     

Comparison of the elastic and inelastic scatterings between152Sm+12C and148 Nd+16O

Angular distributions of elastic and inelastic scattering have been measured for¹⁵²Sm+¹²C at 63.2 MeV and¹⁴⁸Nd+¹⁶O at 90.9 MeV. An evident interference pattern in the inelastic scattering has been observed for the first time in a strong Coulomb coupling system.We are indebted to Dr. S. Pieper for supplying the Ptolemy Program. One of us (Chenglie Jiang) would like to acknowledge the Argonne National Laboratory for the opportunity given, to perform theoretical calculations with the code Ptolemy during his visit there. Thanks are also due to Mr. H. Folger (GSI, Germany) for supplying the targets. This work was supported in part by China National Nature Science Fundation.     

视觉对比度机制小目标增强与背景抑制综述北大核心CSCD

复杂背景中的红外弱小目标因亮度低、尺寸小、可用特征少而难以检测。如何在检测中抑制背景杂波、提高目标信噪比成为该领域的研究热点与难点。本文对基于人类视觉系统对比度机制的小目标增强与背景抑制技术的演进和性能进行了归纳与分析。局部对比度测度窗口由单尺度向多尺度,乃至动态或自适应尺度的发展,满足应用中对未知尺寸小目标同步快速检测的需要;局部对比度测度计算方法由简单到复杂、依据低阶信息到采用高阶信息的变化,有利于更全面地抑制复杂背景、进一步增强目标。因此,将成为未来人类视觉对比度机制小目标检测算法的发展方向。     

Research on the design of metalens with achromatic and amplitude modulation

Metalenses are two-dimensional planar metamaterial lenses, which have the advantages of high efficiency and easy integration. However, most metalenses cannot modulate the light intensity, which limits their applications. To deal with it, taking advantage of flexible regulation of the beam amplitude and phase by the metalens, the geometric phase method is selected to design the dual-function metalens. It can effectively eliminate chromatic aberration in a visible light band from 535 nm to 600 nm and achieve amplitude modulation. After transmitting the metalens, the amplitudes of the beam respectively turn into 0.2 and 0.9. In this way, the amount of transmission of metalens in the preset band can be quantitatively controlled. According to the distribution characteristics of light diffraction intensity, the metalens designed can play a dual modulation role of achromatism and interference double-beam equilibrium in the paper, to meet the needs of miniaturization and integration of the optical system. The achromatic and amplitude-modulated metalens will have great application potential in optical holographic imaging and super-resolution focusing.     

Selenium Substitution in Bithiophene Imide Polymer Semiconductors Enables High-Performance n-Type Organic Thermoelectric

Designing n-type polymers with high electrical conductivity remains a major challenge for organic thermoelectrics (OTEs). Herein, by devising a novel selenophene-based electron-deficient building block, the pronounced advantages of selenium substitution in simultaneously enabling advanced n-type polymers is demonstrated with high mobility (≈2 orders of magnitude higher versus their sulfur-based analogues due to both intensified intra- and inter-chain interactions) and much improved n-doping efficiency (enabled by the largely lowered LUMO level with a ≈0.2 eV margin) of the resulting polymers. Via side chain optimization and donor engineering, the selenium-substituted polymer, f-BSeI2TEG-FT, achieves a highest conductivity of 103.5 S cm⁻¹ and power factor of 70.1 µW m⁻¹ K⁻², which are among the highest values reported in literature for n-type polymers, and f-BSeI2TEG-FT greatly outperformed the sulfur-based analogue polymer by 40% conductivity increase. These results demonstrate that selenium substitution is a very effective strategy for improving n-type performance and provide important structure-property correlations for developing high-performing n-type OTE materials.     

温循条件下电源模块的瞬态热力耦合研究及优化

针对电源模块在温度循环条件下工作的可靠性问题,以典型电源模块为研究对象,基于有限元分析软件建立温循条件下电源模块的瞬态温度分布模型和电源模块的瞬态热力耦合模型,着重分析芯片、玻璃绝缘子等易损区域。在此基础上以玻璃绝缘子的最大热应力和芯片的最高温度为优化目标,对电源模块进行遗传算法优化设计。结果表明,相比其他研究直接施加热载荷条件,采用瞬态热力耦合所得电源模块结果更准确,芯片温度为86.03℃,玻璃绝缘子的热应力为61.27 MPa。经过遗传算法优化的芯片温度为81.85℃,玻璃绝缘子的热应力为37.05 MPa,满足可靠性要求。证明遗传算法与仿真结合,可有效提高产品设计的可靠性。     

基于钛相变边缘传感器的超导单光子探测器特性

研究了基于钛TES的超导单光子探测器的特性,器件尺寸范围为5 μm×5 μm到20 μm×20 μm,集成光学腔体后在1 550 nm波长实测的系统探测效率最高达到72%,最佳能量分辨率为0.26 eV。在此基础上,采用二流体模型提取了基于钛TES的超导单光子探测器的特性参数（包括温度灵敏度、电流灵敏度、热容等）,并模拟计算了基于钛TES的超导单光子探测器的响应时间和能量分辨率,与实验结果完全吻合。结果表明优化探测器尺寸和临界温度,可以同时达到高探测效率和高能量分辨率,实现光子数可分辨的高性能单光子探测器。     

封装器件多应力叠加失效仿真分析与验证

针对某双列直插式(DIP)封装器件在整机温循试验中出现的失效现象,分析在器件与电路板焊接环节、电路板与整机装配环节和整机温循试验环节3个工况下可能的失效原因,对原因分别进行单工况和多工况的失效仿真分析。针对不同仿真模型在不同工况下的叠加仿真难题,提出基于ANSYS Workbench有限元软件的多应力叠加仿真方法,对比单一工况和多种工况下的仿真结果。结果表明,DIP封装器件失效是器件在焊接尺寸不匹配、过定位装配和温循试验三种工况下,机械应力和热应力的叠加使玻璃绝缘子产生裂纹导致的,有限元仿真结果与实验结果基本吻合,为DIP封装器件在多工况下应力叠加失效的故障机理研究提供一种可参考的仿真方法。     

基于V-视差法的道路区域检测算法研究

针对当前基于双目视觉的道路环境分析实时性差、检测不准确等问题,提出了一种改进V视差法的道路区域检测算法。该算法首先对原始图片进行车道线检测确定道路消失点,从而确定图像的感兴趣区域。然后,使用极大最小值约束获取V视差图中的斜线,从而提取道路区域。实验结果表明,由于该方法在确定感兴趣区域后计算原始视差图,因此,速度提高了29.71%,且相对于传统V视差法,算法更好地实现了路面分割;同时,障碍物检测的精确率和召回率两个指标分别提高了2.165%和4.837%。基于该算法具有良好的准确性和实时性,能有效识别道路中的障碍物,因此,可以为车辆提供可行驶区域以及为驾驶员提供辅助作用。