An Overview on the Synthesis of Fused Pyridocoumarins with Biological Interest

Pyridocoumarins are a class of synthetic and naturally occurring organic compounds with interesting biological activities. This review focuses on the synthetic strategies for the synthesis of pyridocoumarins and presents the biological properties of those compounds. The synthesis involves the formation of the pyridine ring, at first, from a coumarin derivative, such as aminocoumarins, hydroxycoumarins, or other coumarins. The formation of a pyranone moiety follows from an existing pyridine or piperidine or phenol derivative. For the above syntheses, [4 + 2] cycloaddition reactions, multi-component reactions (MCR), as well as metal-catalyzed reactions, are useful. Pyridocoumarins present anti-cancer, anti-HIV, antimalarial, analgesic, antidiabetic, antibacterial, antifungal, anti-inflammatory, and antioxidant activities.     

Adult Honeybees and Beeswax as Indicators of Trace Elements Pollution in a Vulnerable Environment: Distribution among Different Apicultural Compartments

Bees in search of diet sources intensively fly within a radius of up to 3 km, encountering nectar, pollen, and water sources which are potentially contaminated. Consequently, their products can provide valuable information about potential pollution. In the current study, 27 macro and trace elements, including the most hazardous ones, were measured in bees, honey, wax, pollen, and larvae, obtained from seven explicitly industrial areas in eastern regions of Slovakia, using a validated ICP-MS method. All the analysed elements were detected at least in one matrix. The detected concentrations of toxic elements, such as Hg, Pb, and Cd were in some cases higher in wax and bee samples, compared with honey, larvae, and pollen. In particular, Pb and Hg maximum concentrations were detected in the wax samples from Poša (3193 µg/kg) and Strážske_A (90 μg/kg). In addition, adult bees accumulated more elements than larvae, while wax and adult bees seemed more suitable for monitoring macro and trace elements in the surrounding environment. Statistical analysis emphasizing bees and wax correlated Cd with the Strážske area, possibly attributed to the intensified industrial activity in this region.     

Predicting the Performance Deterioration of a Three-Shaft Industrial Gas Turbine

The gas turbine was one of the most important technological developments of the early 20th century, and it has had a significant impact on our lives. Although some researchers have worked on predicting the performance of three-shaft gas turbines, the effects of the deteriorated components on other primary components and of the physical faults on the component measurement parameters when considering the variable inlet guide valve scheduling and secondary air system for three-shaft gas turbine engines have remained unexplored. In this paper, design point and off-design performance models for a three-shaft gas turbine were developed and validated using the GasTurb 13 commercial software. Since the input data were limited, some engineering judgment and optimization processes were applied. Later, the developed models were validated using the engine manufacturer’s data. Right after the validation, using the component health parameters, the physical faults were implanted into the non-linear steady-state model to investigate the performance of the gas turbine during deterioration conditions. The effects of common faults, namely fouling and erosion in primary components of the case study engine, were simulated during full-load operation. The fault simulation results demonstrated that as the severity of the fault increases, the component performance parameters and measurement parameters deviated linearly from the clean state. Furthermore, the sensitivity of the measurement parameters to the fault location and type were discussed, and as a result they can be used to determine the location and kind of fault during the development of a diagnosis model.     

New synthesis of hexamethyltungsten(VI); hexamethylrhenium(VI) and dioxotrimethylrh enium(VII)

A new synthesis of hexamethyltungsten involves the reaction of WCl₆ and AlMe₃, while interaction of AlMe₃ and ReOMe₄ gives ReMe₆; a dioxorhenium(VII) methyl, ReO₂ Me₃, is reported.     

Spontaneous Resolution by Crystallization of an Octanuclear Iron(III) Complex Using Only Racemic Reagents

The P and M enantiomers of the octanuclear [Fe₈(μ₄‐O)₄(μ‐4‐Cl‐pz)₁₂Cl₄] complex, having T symmetry, were resolved by temporary substitution of chloride ligands by racemic 4‐^sBu‐phenolates and subsequent crystallization, where the (S)‐ and (R)‐phenolates coordinate selectively to the M and P complexes, respectively. The complexes were characterized by circular dichroism analysis and X‐ray structure determination. This work constitutes a rare example of enantiomeric recognition resulting in spontaneous resolution upon crystallization.     

Unprecedented Five‐Coordinate Iron(IV) Imides Generate Divergent Spin States Based on the Imide R‐Groups

Three five‐coordinate iron(IV) imide complexes have been synthesized and characterized. These novel structures have disparate spin states on the iron as a function of the R‐group attached to the imide, with alkyl groups leading to low‐spin diamagnetic (S=0) complexes and an aryl group leading to an intermediate‐spin (S=1) complex. The different spin states lead to significant differences in the bonding about the iron center as well as the spectroscopic properties of these complexes. Mössbauer spectroscopy confirmed that all three imide complexes are in the iron(IV) oxidation state. The combination of diamagnetism and ¹⁵N labeling allowed for the first ¹⁵N NMR resonance recorded on an iron imide. Multi‐reference calculations corroborate the experimental structural findings and suggest how the bonding is distinctly different on the imide ligand between the two spin states.     

In-plane stability of uniform steel beam-columns on a Pasternak foundation with zero end-shortening

The linearized buckling response of uniform steel beam-columns resting on a Pasternak foundation type is dealt with in this work. The corresponding two-point boundary value problem depends on the two parameters associated with the foundation model, that is, shear layer constant and Winkler spring coefficient, as well as on the axial loading. The fourth-order differential equation of buckling and the consequent characteristic one yield exact values of the buckling loads, which may lead to shape functions, being either one sinusoidal waveform or the sum of two different waveforms. The former case is associated with a single-mode response, while the latter with mode coupling. The conditions for which each of these cases characterizes the beam-column behavior are fully assessed and the dependence on the combination of the aforementioned parameters on the response is discussed in detail. It is found that regardless of the order of coupling, the corresponding mode is not related to rational values of buckling loads and hence this unfavorable phenomenon is excluded in structural design.     

Introduction to PNET special issue on “Resilience in future 5G photonic networks”

Photonic Network Communications -     

Large Power Increase Enabled by High-Q Diamond-Loaded Cavities for Terahertz Gyrotrons

Journal of Infrared, Millimeter, and Terahertz Waves - A new operation scheme is proposed to enable large increase in output power of terahertz gyrotrons. In this scheme, the gyrotron operates in...