Measurements and Characterization for the Vehicle-to-Infrastructure Channel in Urban and Highway Scenarios at 5.92GHz

In the future smart transportation system, reliable vehicle-to-infrastructure(V2 I) communication is very important to ensure vehicle driving safety and to improve vehicle driving efficiency. In this paper, V2 I channel measurements at 5.92 GHz are conducted in typical urban and highway scenarios.The frequency and bandwidth of transmission, as well as the deployment of the RSU(roadside unit) and the OBU(on board unit), are selected by considering the recommendation proposed by 3 GPP TR 36.885. T...     

Mechanism Study on Nanoparticle Negative Surface Charge Modification by Ascorbyl Palmitate and Its Improvement of Tumor Targeting Ability

Surface charge polarity and density influence the immune clearance and cellular uptake of intravenously administered lipid nanoparticles (LNPs), thus determining the efficiency of their delivery to the target. Here, we modified the surface charge with ascorbyl palmitate (AsP) used as a negatively charged lipid. AsP-PC-LNPs were prepared by dispersion and ultrasonication of AsP and phosphatidylcholine (PC) composite films at various ratios. AsP inserted into the PC film with its polar head outward. The pK_a for AsP was 4.34, and its ion form conferred the LNPs with negative surface charge. Zeta potentials were correlated with the amount and distribution of AsP on the LNPs surface. DSC, Raman and FTIR spectra, and molecular dynamics simulations disclosed that AsP distributed homogeneously in PC at 1–8% (w/w), and there were strong hydrogen bonds between the polar heads of AsP and PC (PO²⁻), which favored LNPs’ stability. But at AsP:PC > 8% (w/w), the excessive AsP changed the interaction modes between AsP and PC. The AsP–PC composite films became inhomogeneous, and their phase transition behaviors and Raman and FTIR spectra were altered. Our results clarified the mechanism of surface charge modification by AsP and provided a rational use of AsP as a charged lipid to modify LNP surface properties in targeted drug delivery systems. Furthermore, AsP–PC composites were used as phospholipid-based biological membranes to prepare paclitaxel-loaded LNPs, which had stable surface negative charge, better tumor targeting and tumor inhibitory effects.     

Symplectic perturbation series methodology for non-conservative linear Hamiltonian system with damping

In this paper,the symplectic perturbation series methodology of the non-conservative linear Hamiltonian system is presented for the structural dynamic response ...     

In Vitro and In Vivo Antibacterial Activity,Toxicity and Resistance Analysis of Pleuromutilin Derivative Z33 against Methicillin-Resistant Staphylococcus aureus

The novel pleuromutilin derivative, which showed excellent in vitro antibacterial activity against MRSA, 22-(2-(2-(4-((4-(4-nitrophenyl)piperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)acetamido)phenyl)thioacety-l-yl-22-deoxypleuromutilin (Z33), was synthesized and characterized in our previous work. In this study, the preliminary pharmacodynamics and safety of Z33 were further evaluated. In in vitro antibacterial activity assays, Z33 was found to be a potent bactericidal antibiotic against MRSA that induced dose-dependent growth inhibition and long-term post-antibiotic effect (PAE). The drug-resistance test demonstrated that Z33 possessed a narrow mutant selection window and lower propensities to select resistance than that of tiamulin. Cytochrome P450 (CYP450) inhibition assay determined that the inhibitory effect of Z33 was similar to that of tiamulin against the activity of CYP3A4, and was lower than that of tiamulin on the activity of CYP2E1. Toxicity determination showed that both Z33 and tiamulin displayed low cytotoxicity of RAW264.7 cells. Furthermore, Z33 was found to be a high-security compound with a 50% lethal dose (LD₅₀) above 5000 mg/kg in the acute oral toxicity test in mice. In an in vivo antibacterial activity test, Z33 displayed better therapeutic effectiveness than tiamulin in the neutropenic mouse thigh infection model. In summary, Z33 was worthy of further development as a highly effective and safe antibiotic agent against MRSA infection.     

基于降维算法从少量测量数据中重构温度场

由于测量环境及测量技术的制约,工业中温度信息的获取主要依据少量测点数据,难以得到被测对象完整温度信息。计算方法可以获得被测对象完整温度信息,但计算量大,信息再现实时性差。为了解决这个问题,实现快速、有效、准确的实时温度分布测量,提出一种基于Gappy POD低维表示的温度分布降维重建算法,从少量局部温度测量数据准确中重建温度场,并分析采用上述算法进行温度场重构时POD基个数、测点数量和测点位置对其的影响。通过双峰温度场模型重建结果和误差分析表明,重建误差在1×10^-10以下,且该算法显著地减少了测量传感器的数量,降低了温度分布测量的复杂性与测量成本,为工业测量中数据缺失提供新的解决思路。     

Promote the conductivity of solid polymer electrolyte at room temperature by constructing a dual range ionic conduction path

Poly(ethylene oxide)(PEO) is a classic matrix model for solid polymer electrolyte which can not only dissociate lithium-ions(Li+),but also can conduct Li+through segmental motion in long-range.However,the crystal aggregation state of PEO restricts the conduction of Li⁺ especially at room temperature.In this work,an amorphous polymer electrolyte with ethylene oxide(EO) and propylene oxide(PO) block structure(B-PEG@DMC) synthesized by the transesterification is firstly obtained,showing ...     

基于行过扫数据降低大面阵CCD图像噪声算法研究

针对全帧转移大面阵电荷耦合器件(CCD)多帧图像数据随时间漂移的现象和测试电路引入的噪声,导致无法准确评估CCD器件的参数,文章提出一种基于行过扫数据校正算法。行有效像元数据与对应行垂直过扫数据同时输出,通过有效像元数据减去垂直过扫数据均值,对图像数据漂移的现象进行抑制。测试电路中模拟模块与数字模块同时作用于单行有效像元数据与垂直过扫数据,通过有效像元数据减去垂直过扫数据均值,消除测试电路引入的噪声。实验结果表明,经过该算法校正后的器件读出噪声减小了20%,暗场差值图像中超过15 e^-和25 e^-的比例减小了25%。该算法适用于大面阵CCD器件,可校正测试系统引入的测试误差,提高全帧转移大面阵CCD器件测试效率。     

低强度激光辐照对蝗虫活性的影响

为研究低强度激光辐照对蝗虫活动能力的影响,以减少农药的使用量和降低农药的浓度,选择大功率连续型近红外半导体二极管激光器,针对3龄至4龄期东亚飞蝗蝻虫头部位置,在距离激光发光面4cm处,进行2s和4s的辐照试验,分别观察比较辐照前后蝗虫的活性和活性降低程度．试验结果表明,辐照前,蝗虫具有较高的活性,辐照后蝗虫的活性降低,并逐渐趋于一致性;辐照时间越长,蝗虫的活性降低程度越高。说明低强度近红外激光辐照蝗虫头部位置能明显抑制其活动能力。     

园区网流量分析与控制策略的应用实践

数字化园区网络规模和业务流量快速增长,有限带宽资源被无序过多占用,导致关键网络应用的带宽无法得到保障。通过流量分析与控制设备在园区网内部署灵活的流量控制策略,增加病毒防治措施,减少园区网内病毒传播,合理设置内网资源服务器,以减少园区网出口带宽的负载。实践证明,该方案能够有效优化园区网络带宽资源,减少异常网络攻击流量,合理疏导园区网出口流量,有效保障了园区网关键应用的带宽需求,提高了园区网运行的稳定性。