多元传播时代广播电视转型的研究与应对

本文以电视技术工作者的角度,结合自身的研究成果和对本单位新媒体工作的思考,从整体上分析了传统电视的发展和在互联网环境下面临的挑战,对多元传播时代广播电视的融合转型提出了见解。     

人造多晶冰抗压强度实验研究

对实验室制作的平均粒径为４ｍｍ的宏观各向同性粒状多晶冰，在冰温分别为－０．５、－２、－５和－１０℃及应变率分别为４．２×１０－４、５．５×１０－５、５．５×１０－６及３．５×１０－７ｓ－１下进行了单轴抗压强度实验。结果表明，极限抗压强度与负温和应变率的对数均呈正比例关系；在较高应变率下（４．２×１０－４ｓ－１），在－５℃时，出现韧脆性转折点。     

Au膜结构及其微观应变的测定

介绍用Ｘ－ 射线衍射方法测定Ａｕ 薄膜材料结构及其微观应变 。利用不对称布拉格反射ＳＴＤ（ｓａｍｐｌｅ ｔｉｌ＿ｔｉｎｇ ｄｉｆｆｒａｃｔｉｏｎ） 扫描模式与常规ＣＢＤ（ｃｏｎｖｅｎｔｉｏｎａｌ Ｂｒａｇｇ ｄｉｆｆｒａｃｔｉｏｎ） 扫描模式, 确定Ａｕ 膜的结构及取向, 同时采用直接测量法（ 非卷积法） 来测定Ａｕ 的微观应变。     

中分子物质与血液净化

本文介绍了中分子物质假说及其理论的发展,揭示了中分子物质与疾病的关系,并提示了血液净化疗法在临床应用的实际价值。     

Halogen-magnesium exchange of m- and p-iodo or bromo-arenes bearing ortho-directing groups through ate complexes

m- or p-Iodinated, or brominated ω-phenoxyalcohols and phenols as well as halogenated indoles were subjected to halogen-magnesium exchange reactions with isopropyl magnesium bromide (ⁱPrMgBr) or isopropyl magnesium di-n-butyl lithium ate complexes (ⁱPrMgⁿBu₂Li) at −78 °C to room temperature. ⁱPrMgⁿBu₂Li proved superior to prevent ortho-metallation of these substituted arenes.     

Computational Simulation of HIV Protease Inhibitors to the Main Protease (Mpro) of SARS-CoV-2: Implications for COVID-19 Drugs Design

SARS-CoV-2 is highly homologous to SARS-CoV. To date, the main protease (Mpro) of SARS-CoV-2 is regarded as an important drug target for the treatment of Coronavirus Disease 2019 (COVID-19). Some experiments confirmed that several HIV protease inhibitors present the inhibitory effects on the replication of SARS-CoV-2 by inhibiting Mpro. However, the mechanism of action has still not been studied very clearly. In this work, the interaction mechanism of four HIV protease inhibitors Darunavir (DRV), Lopinavir (LPV), Nelfinavir (NFV), and Ritonavire (RTV) targeting SARS-CoV-2 Mpro was explored by applying docking, molecular dynamics (MD) simulations, and MM–GBSA methods using the broad-spectrum antiviral drug Ribavirin (RBV) as the negative and nonspecific control. Our results revealed that LPV, RTV, and NFV have higher binding affinities with Mpro, and they all interact with catalytic residues His41 and the other two key amino acids Met49 and Met165. Pharmacophore model analysis further revealed that the aromatic ring, hydrogen bond donor, and hydrophobic group are the essential infrastructure of Mpro inhibitors. Overall, this study applied computational simulation methods to study the interaction mechanism of HIV-1 protease inhibitors with SARS-CoV-2 Mpro, and the findings provide useful insights for the development of novel anti-SARS-CoV-2 agents for the treatment of COVID-19.     

Simulation study of the channel on correcting neutron self-shielding effect in bulk coal

Neutron self-shielding effect in bulk materials impairs analysis of elements using prompt gamma-rays induced by thermal neutron capture reaction. For the on-line coal analysis setups of Nanjing Dalu Zhongdian Technology Joint-Stock Co., Ltd, Monte-Carlo simulations have been performed to investigate effect of the channel on correcting neutron self-shielding effect and improving measurement of H in coal. The results show that, by introducing an adequate channel in the moderator, the self-shielding effect can be corrected, and the linear concentration region of H can be extended effectively.     

电路多媒体CAI课件的研制

介绍了由5所高校联合研制,并列入面向21世纪课程教材出版规划的“电路多媒体CAI课件”的设计思想,主要内容和功能特点,探索在电路课程教学的各个环节中的现代化教学手段和教学方法的采用。     

Improvement of anti-oxidation capability and tribological property of arc ion plated Ag film by alloying with Cu

Ag-Cu alloy film was deposited by arc ion plating (AIP). Atomic oxygen (AO) irradiation experiments were conducted using a ground AO simulation facility. The structure, morphology, composition and tribological property of the Ag-Cu alloy film before and after AO irradiation were investigated and compared with Ag film using X-ray diffraction (XRD), field emission scanning electron microscope (FESEM), X-ray photoelectron spectroscope (XPS) and ball-on-disk tribometer, respectively. In depth XPS analysis clearly shows that the affected thickness of Ag-Cu alloy film was greatly reduced and the oxidation product was mainly Ag₂O, but AgO and Ag₂O in case of pure Ag film. As a result, the Ag-Cu alloy film exhibited better AO resistant behaviors, and showed a stable friction and low wear after the AO irradiation. The AO resistant behaviors of the Ag-Cu alloy film were discussed in terms of the film microstructure.