Nanostructured Porous Silicon‐Solid Lipid Nanocomposite: Towards Enhanced Cytocompatibility and Stability,Reduced Cellular Association,and Prolonged Drug Release

A major bottleneck in nanometer‐scale drug delivery systems is the fabrication of nanocarriers with excellent stability under physiological conditions that can both efficiently encapsulate therapeutic agents and controllably release their payloads. Herein, the formation of a novel nanocomposite based on the encapsulation of thermally hydrocarbonized porous silicon (THCPSi) nanoparticles with solid lipid nanoparticles (SLNs) on a 1:1 ratio is described. The THCPSi‐SL nanocomposites (THCPSi‐SLNCs) are formed using a solid‐in‐oil‐in‐water emulsion solvent evaporation method. TEM and FTIR analyses prove that THCPSi nanoparticles are successfully encapsulated in the SLN matrix. The formation of the THCPSi‐SLNCs alters the surface smoothness and hydrophobicity of the THCPSi nanoparticles, and also remarkably enhances their stability in human plasma. After encapsulation, the cytocompatibility of the THCPSi nanoparticles with intestinal, liver, and macrophage cancer cells is also greatly improved. A prolonged release of the model drug, furosemide, from THCPSi‐SLNC is achieved, indicating that the SLN matrix successfully seals the pores of the THCPSi nanoparticles. Flow cytometry and confocal fluorescence microscopy studies demonstrates the significantly reduced cellular association of THCPSi‐SLNCs with the cells comparing to bare THCPSi nanoparticles. Overall, the THCPSi‐SLNCs exhibits superior suspensibility and better stability against aggregation in aqueous buffer solutions, increases the particle surface smoothness and cytocompatibility, reduces the cellular association, increases the in vitro stability in human plasma, and prolonges the drug release. These results suggest that the nanocomposite is a promising nanovector system for drug delivery applications.     

Note on multidimensional Breeden–Litzenberger representation for state price densities

In this note, we consider European options of type $h(X^1_T, X^2_T,\ldots , X^n_T)$ depending on several underlying assets. We give a multidimensional version of the result of Breeden and Litzenberger (J Bus 51:621–651, 1978) on the relation between derivatives of the call price and the risk-neutral density of the underlying asset. The pricing measure is assumed to be absolutely continuous with respect to the Lebesgue measure on the state space.     

Development of a GPU-based high-performance radiative transfer model for the Infrared Atmospheric Sounding Interferometer (IASI)

Satellite-observed radiance is a nonlinear functional of surface properties and atmospheric temperature and absorbing gas profiles as described by the radiative transfer equation (RTE). In the era of hyperspectral sounders with thousands of high-resolution channels, the computation of the radiative transfer model becomes more time-consuming. The radiative transfer model performance in operational numerical weather prediction systems still limits the number of channels we can use in hyperspectral sounders to only a few hundreds. To take the full advantage of such high-resolution infrared observations, a computationally efficient radiative transfer model is needed to facilitate satellite data assimilation. In recent years the programmable commodity graphics processing unit (GPU) has evolved into a highly parallel, multi-threaded, many-core processor with tremendous computational speed and very high memory bandwidth. The radiative transfer model is very suitable for the GPU implementation to take advantage of the hardware’s efficiency and parallelism where radiances of many channels can be calculated in parallel in GPUs.In this paper, we develop a GPU-based high-performance radiative transfer model for the Infrared Atmospheric Sounding Interferometer (IASI) launched in 2006 onboard the first European meteorological polar-orbiting satellites, METOP-A. Each IASI spectrum has 8461 spectral channels. The IASI radiative transfer model consists of three modules. The first module for computing the regression predictors takes less than 0.004% of CPU time, while the second module for transmittance computation and the third module for radiance computation take approximately 92.5% and 7.5%, respectively. Our GPU-based IASI radiative transfer model is developed to run on a low-cost personal supercomputer with four GPUs with total 960 compute cores, delivering near 4 TFlops theoretical peak performance. By massively parallelizing the second and third modules, we reached 364× speedup for 1 GPU and 1455× speedup for all 4 GPUs, both with respect to the original CPU-based single-threaded Fortran code with the –O₂ compiling optimization. The significant 1455× speedup using a computer with four GPUs means that the proposed GPU-based high-performance forward model is able to compute one day’s amount of 1,296,000 IASI spectra within nearly 10 min, whereas the original single CPU-based version will impractically take more than 10 days. This model runs over 80% of the theoretical memory bandwidth with asynchronous data transfer. A novel CPU–GPU pipeline implementation of the IASI radiative transfer model is proposed. The GPU-based high-performance IASI radiative transfer model is suitable for the assimilation of the IASI radiance observations into the operational numerical weather forecast model.     

Tailoring Covalent Organic Frameworks To Capture Water Contaminants

Covalent organic frameworks (COFs) are attractive materials receiving increasing interest in the literature due to their crystallinity, large surface area, and pore uniformity. Their properties can be tailored towards specific applications by judicious design of COF building blocks, giving access to tailor-made pore sizes and surfaces. In this Concept article, developments in the field of COFs that have allowed these materials to be explored for contaminant adsorption are discussed. Strategies to obtain water-stable materials with highly ordered structures and large surface areas are reviewed. Post-synthetic modification approaches, by which pore surfaces can be tuned to target specific contaminants, are described. Recent advances in COF formulations, crucial for future implementation in adsorption devices, are highlighted. At the end, future challenges which need to be addressed to allow for the deployment of COFs for the capture of water contaminants will be discussed.     

Lindelöf type of generalization of separability in Banach spaces

We will introduce the countable separation property (CSP) of Banach spaces X, which is defined as follows: X has CSP if each family E of closed linear subspaces of X whose intersection is the zero space contains a countable subfamily E₀ with the same intersection. All separable Banach spaces have CSP and plenty of examples of non-separable CSP spaces are provided. Connections of CSP with Marku?evi?-bases, Corson property and related geometric issues are discussed.     

Hydrolytic reactions of thymidine 5'-o-phenyl-N-alkylphosphoramidates, models of nucleoside 5'-monophosphate prodrugs

To obtain detailed data on the kinetics of hydrolytic reactions of triester-like nucleoside 5'-O-aryl-N-alkylphosphoramidates, potential prodrugs of antiviral nucleoside monophosphates, the hydrolysis of diastereomeric (Rp/Sp) thymidine 5'-{O-phenyl-N-[(1S)-2-oxo-2-methoxy-1-methylethyl]phosphoramidate} (3), a phosphoramidate derived from the methyl ester of L-alanine, has been followed by reversed-phase HPLC over the range from Ho=0 to pH 8 at 90 degrees C. According to the time-dependent product distributions, the hydrolysis of 3 proceeds at pH<4 by two parallel routes, namely by nucleophilic displacement of the alaninyl ester moiety by a water molecule and by hydrolysis of the carboxylic ester linkage that allows intramolecular attack of the carboxy group on the phosphorus atom, thereby resulting in the departure of either thymidine or phenol without marked accumulation of any intermediates. Both routes represent about half of the overall disappearance of 3. The departure of phenol eventually leads to the formation of thymidine 5'-phosphate. At pH>5, the predominant reaction is hydrolysis of the carboxylic ester linkage followed by intramolecular displacement of a phenoxide ion by the carboxylate ion and hydrolysis of the resulting cyclic mixed anhydride into an acyclic diester-like thymidine 5'-phosphoramidate. The latter product accumulated quantitatively without any indication of further decomposition. Hydroxide-ion-catalyzed P--OPh bond cleavage of the starting material 3 occurred as a side reaction. Comparative measurements with thymidine 5'-{N-[(1S)-2-oxo-2-methoxy-1-methylethyl]phosphoramidate} (4) revealed that, under acidic conditions, this diester-like compound is hydrolyzed by P--N bond cleavage three orders of magnitude more rapidly than the triester-like 3. At pH>5, the stability order is reversed, with 3 being hydrolyzed six times as rapidly as 4. Mechanisms of the partial reactions are discussed.     

Improved models for long-term prediction of troposphericscintillation on slant paths

The prediction models for tropospheric scintillation on Earth-satellite paths from Karasawa, Yamada, and Allnutt (1988) and the ITU-R are compared with measurement results from satellite links in Europe, the United States, and Japan at frequencies from 7 to 30 GHz and elevation angles of 3 to 33°. The existing prediction models relate the long-term average scintillation intensity to the wet term of refractivity at ground level. The comparison shows that the seasonal variation of scintillation intensity is well predicted by this relation, but for the annual average some additional meteorological information is needed. A much better agreement with measurement results is found when a parameter representing the average water content of heavy clouds is incorporated. This confirms the assumption that scintillation is, at least partly, associated with turbulence inside clouds. The asymmetry between the distributions of signal fade and enhancement can also be explained by turbulence inside clouds. The asymmetry depends on the intensity of the scintillation, which is consistent with the theory assuming a thin layer of cloudy turbulence. A new model based on this theory predicts the distributions of signal fade and enhancement significantly better     

On the existence of Nash equilibria in large games

We study the existence of Nash equilibria in games with an infinite number of players. We show that there exists a Nash equilibrium in mixed strategies in all normal form games such that pure strategy sets are compact metric spaces and utility functions are continuous. The player set can be any nonempty set.     

Configurable Data Memory for Multimedia Processing

In modern multimedia applications, memory bottleneck can be alleviated with special stride data accesses. Data elements in stride access can be retrieved in parallel with parallel memories, in which the idea is to increase memory bandwidth with several memory modules working in parallel and feed the processor with only necessary data. Arbitrary stride access capability with interleaved memories is described in previous research where the skewing scheme is changed at run time according to the currently used stride. This paper presents the improved schemes which are adapted to parallel memories. The proposed novel parallel memory implementation allows conflict free accesses with all the constant strides which has not been possible in prior application specific parallel memories. Moreover, the possible access locations are unrestricted and the accessed data element count equals to the number of memory modules. Timing and area estimates are given for Altera Stratix FPGA and 0.18 micrometer CMOS process with memory module count from 2 to 32. The FPGA results show 129 MHz clock frequency for a system with 16 memory modules when read and write latencies are 3 and 2 clock cycles, respectively. The complexity of the proposed system is shown to be a trade-off between application specific and highly configurable parallel memory system.