Tumor Microenvironment-Activated NIR-II Nanotheranostic System for Precise Diagnosis and Treatment of Peritoneal Metastasis

Activatable theranostic systems show potential for improved tumor diagnosis and therapy owing to high detection specificities, effective ablation, and minimal side-effects. Herein, a tumor microenvironment (TME)-activated NIR-II nanotheranostic system (FEAD1) for precise diagnosis and treatment of peritoneal metastases is presented. FEAD1 was fabricated by self-assembling the peptide Fmoc-His, mercaptopropionic-functionalized Ag₂S quantum dots (MPA-Ag₂S QDs), the chemodrug doxorubicin (DOX), and NIR absorber A1094 into nanoparticles. We show that in healthy tissue, FEAD1 exists in an NIR-II fluorescence “off” state, because of Ag₂S QDs-A1094 interactions, while DOX remains in stealth mode. Upon delivery of FEAD1 to the tumor, the acidic TME triggers its disassembly through breakage of the Fmoc-His metal coordination and DOX hydrophobic interactions. Release of A1094 switches on Ag₂S fluorescence, illuminating the tumor, accompanied by burst release of DOX within the tumor tissue, thereby achieving precise tumor theranostics. This TME-activated theranostic strategy holds great promise for future clinical applications.     

Performance of the Zero Forcing precoding MIMO broadcast systems with channel estimation errors

In this paper, the effect of channel estimation errors upon the Zero Forcing (ZF) precoding Multiple Input Multiple Output Broadcast (MIMO BC) systems was studied. Based on the two kinds of Gaussian estimation error models, the performance analysis is conducted under different power allocation strategies. Analysis and simulation show that if the covariance of channel estimation errors is independent of the received Signal to Noise Ratio (SNR), imperfect channel knowledge deteriorates the sum capacity and the Bit Error Rate (BER) performance severely. However, under the situation of orthogonal training and the Minimum Mean Square Error (MMSE) channel estimation, the sum ca- pacity and BER performance are consistent with those of the perfect Channel State Information (CSI) with only a performance degradation.     

用于燃料电池质子交换膜的含萘及氮杂环结构的新型磺化聚酰亚胺的合成及性能

将自制的4,4'-二氨基二苯醚-2,2'-二磺酸基(ODADS)、 含氮杂环芳香二胺1,2-二氢-2-(4-氨基苯基)-4-[4-(4-氨基苯氧基)-苯基]-二氮杂萘-1-酮(DHPZ-DA)和1,4,5,8-萘四甲酸二酐(NTDA)进行直接缩合聚合反应, 通过改变磺化二胺单体的含量来改变聚合物的磺化度, 成功地合成了一系列高分子量的不同磺化度的六元环聚酰亚胺(SPIs), 其特性粘度在0.55-1.47 dL/g. 采用FTIR和 1H NMR技术表征了聚合物的结构. 研究了经溶液浇铸成磺化聚合物膜的理化性质. 结果表明, 随着聚合物磺化度的增大, 膜的含水率和离子交换能力增大, 尺寸稳定性、 对水的稳定性以及抗氧化性降低.     

光子晶体光纤拉制参数对包层气孔结构的影响

分析了光子晶体光纤(PCF)拉丝工艺参数对光纤毛细管及最终结构的影响,结果表明,通过调节温度、送料速度和拉制速度等参数可以在一定程度上调整最终的气孔结构,但难以拉制出结构完善的PCF.为此提出了惰性气体施压法,实验表明,通过调节施压量的同时结合上述参数的调节,可有效控制光纤的结构参数,拉制出横纵向均匀性良好的PCF.     

大功率光纤放大器分段泵浦方式下的理论分析

利用数值算法计算了掺镱双包层光纤放大器分段泵浦方式下的稳态速率方程组,分析比较了双端泵浦和多段泵浦方式下的最佳光纤长度,最高温度和效率,并采用遗传算法对分布泵浦功率的大小和每段光纤长度同时进行了优化。结果表明,通过优化,大功率分段泵浦光纤放大器获得了较为平坦的温度分布,与双端泵浦相比,大大降低了最高工作温度,斜率效率略有下降。     

地球同步轨道二维扫描像移补偿技术建模与分析

在建立二维扫描观测模型的基础上,提出了基于椭球体地球模型的二维扫描像移补偿方案,给出了任意空间观测到的目标位置的快速迭代算法,并以真实轨道和仿真姿态数据验证了像移补偿模型的实际性能。仿真结果表明,对于长周期(大于一个东西方向扫描行周期)轨道和姿态偏差,可以通过调整仪器坐标系内的扫描轨迹来实现像移补偿;同时,在现有轨道测量和控制条件下,轨道因素引起的瞬时方位角和俯仰角补偿量在0.01°~0.1°量级,且随轨道位置不同而变化。FY-2C卫星在轨偏航轴姿态失配修正实例证实了上述模型的有效性。     

Synthesis,Crystal Structure and Property Studies on a Bipyridine Adduct of Nickel Xanthogenate

A new coordination polymer containing mixed ligands, namely [Ni(S_2COiBu)_2(DBPMF)·(CHCl_3)]_∞(DBPMF = 2,7-dibromo-9,9-(4-pyridylmethyl)fluorine), has been synthesized and structurally characterized by elemental analysis and single-crystal X-ray diffractions. X-ray structural analysis reveals that each Ni atom is coordinated by two isobutyl xanthogenate molecules and two nitrogen atoms from two DBPMF ligands to form octahedral coordination geometry. DBPMF acts as a bridge to form a coordination polymer. Fluorescence property of this coordination polymer displays a broad emission band at λ = 413 nm. Thermal analysis shows that the solvent molecule CHCl_3 can be stabilized in the crystal structure until 140 ℃.     

基于单片机的双向DC-DC充放电电路设计

环境污染和能源短缺一直阻碍着中国绿色经济的发展,新能源的开发利用有助于扫出这个障碍,超级电容和双向DC-DC变换器构成的储能系统,在新能源的开发利用过程中占据了重要的位置.本文对双向Buck/Boost变换器进行了研究,在单片机STM32F103C8T6的控制下,设计了一个充放电系统,实现了超级电容的恒流充电和恒压放电...     

Performance of closed loop transmit diversity in a Rayleigh fading channel

In this paper, the closed loop transmit diversity technology for the Wideband Code Division Multiple Access（WCDMA） systems is investigated in a multipath Rayleigh fading channel. The RAKE receiver model and the weighing vector algorithm are presented. The performance is theoretically analyzed in terms of the average maximal Signal-to-Noise Ratio（SNR） gain available over the Space-Time block coding based Transmit Diversity（STTD） technology. Theoretic analysis and simulation results show that the closed loop transmit diversity can provide a 3dB performance gain over the open loop scheme in a single path fading channel, while the performance gain decreases dramatically with the increasing inherent multipath diversity of the wireless channel.     

PSTM金属样品成像实验的数值模拟

本文采用时域多分辨分析法（MRTD）,并利用FDTD方法的完全匹配层（UPML）作为边界条件,对Eckert等人在实验中所使用的喷溅金属铝小块样品作了数值模拟分析,给出了在PSTM模型中喷溅金属铝小块样品的数值模拟的三维图像,并对试验结果和理论结果进行了比较和分析,验证了Eckert等人的实验。