Simulation analysis of the effects of a back surface field on a p-a-Si:H/n-c-Si/n+-a-Si:H heterojunction solar cell

In order to investigate the effects of a back surface field（BSF） on the performance of a p-doped amorphous silicon（p-a-Si：H）/n-doped crystalline silicon（n-c-Si） solar cell,a heterojunction solar cell with a p-a-Si：H/n-c-Si/n^＋-a-Si：H structure was designed.An n^＋-a-Si：H film was deposited on the back of an n-c-Si wafer as the BSF.The photovoltaic performance of p-a-Si：H/n-c-Si/n^＋-a-Si：H solar cells were simulated.It was shown that the BSF of the p-a-Si：H/n-c-Si/n^＋-a-Si：H solar cells could effectively inhibit the decrease of the cell performance caused by interface states.     

Rapid design space exploration by hybrid fuzzy search approach for optimal architecture determination of multi objective computing systems

Design Space Exploration (DSE) with multi-parametric objective in High Level Synthesis (HLS) involves assessing the various design points in the architecture design space to find the optimum solution for the design according to the system requirements specified. Due to the time to market pressure, the cost of solving the problem of architecture selection by exhaustive analysis is strictly forbidden. The tradeoffs linked to the selection of the appropriate design point during architecture evaluation needs careful assessment for efficient design space exploration. Further DSE requires satisfying multiple conflicting multi objective conditions such as increase in accuracy of evaluation during DSE with simultaneous speedup in the exploration process. This paper presents a novel hybrid design space exploration approach which is a combination of the Priority Factor (PF) method and Fuzzy search technique that is rapid and accurate in architecture evaluation and selection. The proposed approach for DSE when applied on a number of benchmarks yielded superior results compared to the current existing DSE approach for architecture selection. The comparison results of the proposed hybrid approach with the current existing approach for different benchmarks are shown and the speedups obtained are also presented.     

Vortex Counter-Current Chromatography: Performance of a New Preparative Column

A new preparative column for the vortex counter-current chromatograph was fabricated by making many (966) cylindrical separation units to a high-density polyethylene disk and then threading them with 6–40 taps. The resulting column had a total capacity of 364 mL. The performance of this vortex column was examined with three different two-phase solvent systems each using a set of suitable test samples: hexane–ethyl acetate–methanol–0.1 M hydrochloric acid (1:1:1:1, v/v) for the separation of DNP-amino acids; 1-butanol–acetic acid–water (4:1:5, v/v) for the separation of dipeptides; and hexane–acetonitrile–water (20:15:2, v/v) for the separation of Sudan dyes. Most of the separations show high partition efficiency of over a thousand theoretical plates, as expected based on the results previously obtained in preliminary separations with a small column. Overall, the results of the present study suggest that further improvement of the partition efficiency can be obtained by the modifying column configuration.

     

Biological evaluation of novel selenazole‐based compounds as potential thioredoxin reductase inhibitors

Recently, thioredoxin reductase as a target for treatment of tumors has attracted the attention of scientists. 1,2‐[Bis(1,2‐benzisoselenazolone‐3(2 H)‐ketone)]ethane (ethaselen, BBSKE, PCT: CN02/00412), designed and synthesized previously, is an effective thioredoxin reductase inhibitor; presently it is in phase II clinical trials, targeting gastric cancer, lung cancer and colon cancer. To seek more novel and effective anticancer drugs, we have developed many selenazole‐based compounds. Evaluation of the thioredoxin reductase inhibitory effect and investigation of the mechanism of anticancer drugs require abundant thioredoxin reductase, but since commercial thioredoxin reductase is expensive its use is often limited. Therefore, the preparation of thioredoxin reductase is necessary. Base on the above investigation, in this work we have prepared thioredoxin reductase and evaluated selenazole‐based compounds, and found that 44 compounds have high inhibitory effect on thioredoxin reductase with IC₅₀ < 10 µ m , of which 16 compounds have IC₅₀ values below 1 µ m . This is helpful in investigating and elucidating the mechanism of this kind of compound. Copyright © 2012 John Wiley & Sons, Ltd.     

Synthesis and Crystal Structure of New Thiazolyl-Pyrazoline Derivatives Bearing 1,2,4-Triazole Moiety

Abstract  

The title compounds 1-(4-aryl-5-triazolyl-2-thiazolyl)-3,5-diaryl-2-pyrazoline derivatives (3a–c) were synthesized by reacting 3,5-diaryl1-thiocarbamoyl -2-pyrazoline 1 with 2-bromo-1-aryl-2-(1H-1,2,4-triazol-1-yl) ethanones 2 in boiling ethanol. Their structures were characterized by IR, ¹H-NMR, MS spectroscopic data and elementary analyses. The structure of compound (3a), C₂₆H₁₈Cl₂N₆S, was conclusively established with X-ray crystal structure analysis. It crystallizes in the Orthorhombic space group Pna2(1), with a = 17.8160(5), b = 18.9125(7), c = 14.7926(4), α = 90°, β = 90°, γ = 90°and Dc = 1.379 mg/m³ for Z = 8, V = 4984.3(3) ?, μ(Mo–Kα) = 0.372 mm, λ = 0.71070 ?, the final R = 0.0527 and wR = 0.1307 for 43309 observed reflections with I > 2σ(I). The structure is stabilized by weak C–H···N intramolecular hydrogen bonds and C–H···Cg p-ring intermolecular interactions and gives support to molecular packing stability in the unit cell.     

自旋转移力矩磁隧道结的建模与仿真

自旋转移力矩磁隧道结(STT-MTJ)是一种新兴的非易失性存储单元.因为有着掉电后数据不丢失、无限的写次数、与CMOS工艺兼容、不会增加器件面积以及良好的可缩放性等诸如多优点而得到了广泛的研究.但是由于目前的工艺厂商尚未推出相应的模型,研究者难以先期使用该技术进行电路设计.文章介绍了STT-MTJ的工作原理,详细研究了使用Verilog-A对STT-MTJ建模的思路,并在HSPICE中进行了仿真验证,为后续的STT-MTJ研究奠定了基础.     

Quantitative microfluidic biomolecular analysis for systems biology and medicine

In the postgenome era, biology and medicine are rapidly evolving towards quantitative and systems studies of complex biological systems. Emerging breakthroughs in microfluidic technologies and innovative applications are transforming systems biology by offering new capabilities to address the challenges in many areas, such as single-cell genomics, gene regulation networks, and pathology. In this review, we focus on recent progress in microfluidic technology from the perspective of its applications to promoting quantitative and systems biomolecular analysis in biology and medicine.     

Direct Blue 71 staining as a destaining‐free alternative loading control method for Western blotting

In Western blotting, a suitable loading control is indispensable for correcting errors in the total amount of loaded protein. Immunodetection of housekeeping proteins and total protein staining have traditionally been used as loading control methods. Direct Blue 71 (DB71) staining—a novel, sensitive, dye‐binding staining method compatible with immunodetection—may offer advantages over these traditional loading control methods. Three common neuroscientific samples (human plasma, human oligodendrocytes, and rat brain) were employed to assess DB71 staining as a loading control method for Western blotting. DB71, CBB, one traditional housekeeping protein, and one protein of interest were comparatively assessed for reliability and repeatability and linear dynamic range over 2.5–40 μg of protein loaded. DB71's effect on the reliability and repeatability and linear dynamic range of immunoreaction were also assessed. Across all three sample types, DB71 was either equivalent or superior to CBB and housekeeping protein‐based methods in terms of reliability and repeatability and linear dynamic range. Across all three sample types, DB71 staining did not impair the reliability and repeatability or linear dynamic range of immunoreaction. Our results demonstrate that the DB71 staining can be used as a destaining‐free alternative loading control method for Western blotting.