Semi-supervised and Unsupervised Privacy-Preserving Distributed Transfer Learning Approach in HAR Systems

Wireless Personal Communications - One of the challenges faced by machine learning in human activity recognition systems is the different distributions of the training and test samples. Transfer...     

Dynamic half-Fourier single-shot turbo spin echo for assessment of deep venous thrombosis: initial observations

Objective

The objective of this study was to retrospectively analyze the value of dynamic half-Fourier single-shot turbo spin echo (HASTE) imaging in patients with suspected deep venous thrombosis (DVT).

Materials and Methods

Fifty-five veins in 24 patients were interrogated using a HASTE sequence with the patients relaxed and in various degrees of Valsalva. Veins were analyzed for changes in caliber (+CAL) and signal intensity (+SI) or in their absence (−CAL and −SI, respectively) and compared with the presence of thrombus on gadolinium-enhanced magnetic resonance imaging.

Results

There was no thrombus in veins with the +CAL, +SI pattern (n=40) (P<.01). Five of seven veins (71.4%) with the −CAL, −SI pattern had thrombus (P<.01). A qualitative change in CAL had a sensitivity of 100% and a specificity of 91% for the presence of thrombus. An increase of 1.5 mm in CAL had a sensitivity of 100% and a specificity of 93% for this diagnosis.

Conclusion

Dynamic HASTE imaging offers a physiological method to evaluate veins for deep venous thrombosis.     

Analytical techniques and bioactivity assays to compare the structure and function of filgrastim (granulocyte-colony stimulating factor) therapeutics from different manufacturers

The FDA has approved more than 100 protein and peptide drugs with hundreds more in the pipeline (Lanthier et al. in Nat Rev Drug Discov 7(9):733–737, 2008). Many of these originator biologic products are now coming off patent and are being manufactured by alternate methods than the innovator as follow-on drugs. Because changes to the production method often lead to subtle differences (e.g., degradation products, different posttranslational modifications or impurities) in the therapeutic (Schiestl et al. in Nat Biotechnol 29(4):310–312, 2011), there is a critical need to define techniques to test and insure the quality of these drugs. In addition, the emergence of protein therapeutics manufactured by unapproved methodologies presents an ongoing and growing regulatory challenge. In this work, high-resolution mass spectrometry was used to determine the presence or absence of posttranslational modifications for one FDA-approved and three foreign-sourced, unapproved filgrastim products. Circular dichroism (CD) was used to compare the secondary structure and probe the temperature stability of these products. Native 2D ¹H,¹⁵N-heteronuclear singular quantum coherence (HSQC) NMR test was applied to these samples to compare the higher-order structure of the four products. Finally, a cell proliferation assay was performed on the filgrastims to compare their bioactivity, and stressed filgrastim was tested in the bioassay to better understand the effects of changes in protein structure on activity. The results showed that orthogonal approaches are capable of characterizing the physiochemical properties of this protein drug and assessing the impact of structural changes on filgrastim purity and potency.     

Entropy generation of nanomaterial through a tube considering swirl flow tools

Journal of Thermal Analysis and Calorimetry - The focus of the current investigation is on insertion of complex-shaped device for inducing swirl intensity. H2O-based copper oxide mixture was...     

Maillage simplicial d'un polyèdre arbitraire

Issues related to the existence of a triangulation of an arbitrary polyhedron are addressed. Given a boundary surface mesh (a set of triangular facets), the problem to decide whether or not a triangulation (with no internal points apart from the Steiner points) exists is reported to be NP-hard. In this paper, an algorithm to triangulate a general polyhedron is used which makes use of a classical Delaunay triangulation algorithm, a phase for recovering the missing boundary facets by means of facet partitioning and a final phase that makes it possible to remove the additional (non-Steiner) points previously defined so as to recover the initial boundary mesh thus resulting in a mesh of the given polyhedron. To cite this article: P.-L. George, H. Borouchaki, C. R. Acad. Sci. Paris, Ser. I 338 (2004).     

Impact of MHD on hybrid nanomaterial free convective flow within a permeable region

Journal of Thermal Analysis and Calorimetry - Computational modeling was employed to scrutinize the nanomaterial influence of flow patterns and thermal treatment within a porous region....     

Remaillage adaptatif pour la mise en forme des tôles minces

Problems associated with finite element simulation of the forming processes are characterized by large elastoplastic deformations, evolutive contact with friction, geometrical nonlinearities inducing a severe distortion of the computational mesh of the domain. In this case, frequent remeshing of the deformed domain during computation are necessary to obtain an accurate solution and complete the computation until the termination of the numerical simulation process. This Note presents a new adaptive remeshing method of thin sheets for numerical simulation of metal forming processes. The proposed method is based on geometrical criteria and does not use the geometry of the forming tools. It is integrated in a computational environment using the ABAQUS solver. Numerical examples are given to show the efficiency of our approach. To cite this article: L. Moreau et al., C. R. Mecanique 333 (2005).     

Diagramme de Laguerre

This Note presents a generalization of a known fast and robust algorithm of incremental construction of the Delaunay triangulation to the case of the regular triangulation of points in ${\mathbb{R}}^d$. In particular, the transport formula of simplex circumball centers are naturally extended to the case of the regular triangulation. The associated Laguerre diagram can then be obtained by duality from the regular triangulation. Some numerical examples of Laguerre diagrams in three dimensions are given. To cite this article: H. Borouchaki et al., C. R. Mecanique 333 (2005).     

Analysis of hybrid nanofluid behavior within a porous cavity including Lorentz forces and radiation impacts

Journal of Thermal Analysis and Calorimetry - We investigate the hybrid nanofluid convection transportation within a permeable medium in appearance of an externally applied magnetic force by...     

Nanomaterial between two plates which are squeezed with impose magnetic force

Journal of Thermal Analysis and Calorimetry - Current investigation is surveyed the role of altering Lorentz force on nanomaterial flowing within two discs and its thermal behavior. The basis...