On the dependence of a characterization of proteomics maps on the number of protein spots considered

We have reexamined the numerical characterization of proteomics maps based on the construction of novel distance matrices associated with the nearest neighbor graph for the protein spots. In particular we consider dependence of a characterization of proteomics map on the number of proteins considered in the analysis. We examined a collection of proteomics maps in which we approximately doubled the number of spots to be used for quantitative analysis, considering cases of maps having 30, 50, 100, 250, 500, and 1054 protein spots. For each case we have compared the similarity-dissimilarity results for five proteomics maps of rat liver cells associated with the control group and four proliferators administrated by intraperitoneal injection. We found that proteins maps based on a set of about the 250 most abundant proteins spots suffice for a satisfactory numerical characterization of such maps.     

Combinatorial cell complexes and Poincaré duality

We define and study a class of finite topological spaces, which model the cell structure of a space obtained by gluing finitely many Euclidean convex polyhedral cells along congruent faces. We call these finite topological spaces, combinatorial cell complexes (or c.c.c). We define orientability, homology and cohomology of c.c.c’s and develop enough algebraic topology in this setting to prove the Poincaré duality theorem for a c.c.c satisfying suitable regularity conditions. The definitions and proofs are completely finitary and combinatorial in nature.     

Dynamic threshold voltage operation in Si and SiGe source junctionless tunnel field effect transistor

We propose a dynamic threshold voltage junctionless tunnel FET(DT-JLTFET) in which the threshold voltage can be dynamically adjusted,resulting in higher ON-current.Through 2D numerical simulations,it is presented that the threshold voltage in the DT-JLTFET can be adjusted by applying a voltage to the adjust gate.The impact of the threshold voltage shift on the overall performance of the device is also studied.A comparison is made between the dynamic threshold voltage characteristics of a silicon JLTFET and a Si0:7Ge0:3 source JLTFET.     

Quantitative molecular similarity analysis (QMSA) methods for property estimation: A comparison of property-based,arbitrary, and tailored similarity spaces

Three classes of arbitrary quantitative molecular similarity analysis (QMSA) methods have been computed using atom pairs, topological indices, and physicochemical properties. Tailored QMSA models have been developed using a selected number of TIs chosen by ridge regression. The methods have been applied to the K -nearest neighbor based estimation of log P of two sets of chemicals. Results show that the property-based and tailored QMSA methods are superior to the arbitrary similarity methods in estimating log P of both sets of chemicals