STUDY ON THE BLOOD FAT REGULATION OF THE FUCOIDA-GALACTOSAN SULFATE (FGS) FROM LAMINARIA JAPONICA

1. INTRODUCTION Blood fat primarily contains cholesterol, cholesterol ester, phosphatide, triglyceride and free fatty acid in serum of human being and mammalian. Under physiological conditions, the lipids transport in the form of lipoproteins linked with the proteins. Except for the free fatty acid linked with albumin, the other lipids are linked with the globular proteins into high-density lipoproteins (HDL), low density lipoproteins (LDL), very low density lipoproteins (VLDL) and so…     

Synthesis,Structure,and Ring-opening Metathesis Polymerization of η~5-Pentamethylcyclopentadienyl-(η~5-exo-tricyclo [5.2.1.0~(2,6)]deca-2,5,8-trien-6-yl) Iron

η5-Pentamethylcyclopentadienyl-(η5-exo-tricyclo[5.2.1.02,6]deca-2,5,8-trien-6-yl) iron(3) was synthesized and characterized by 1H NMR, 13C NMR, MS, elemental analysis, IR, UV and X-ray diffraction analysis. Compound 3 was polymerized with ring-opening metathesis polymerization(ROMP) initiator (PCy3)2Cl2Ru=CHPh. 1H NMR and IR spectra revealed the presence of CH=CH units in the polymer and supported the ROMP mechanism. GPC analysis of the polymer showed that the weight-average molecular weights(Mw) was 5967, ...     

Spectral and Mechanistic Studies of the Reactions of Substituted 1,5-Benzothiazepine with Dichloroacetyl Chloride and Triethylamine

A lot of attentions have been paid to the synthesis of benzothiazepines and derivatives1,2 due to their significant physiological activities. It has been reported that b-lactam, a major part of the antibiotic skeleton, can be introduced to a molecule by reaction of an imine moiety with ketene3,4. We introduced a b-lactam skeleton to benzothiazepine and hoped the new compounds may possess certain biological activities. SHNH3ClCHCHCOC2H5OHSNClCla: ortho-Clb: para-Cl+PyridineScheme …     

Two New Compounds from Goniothalamus Cheliensis Hu

Goniothalamus cheliensis Hu (Annonaceace) is a small tree or shrub in Yunnan Province, southwest of China. Acetogenins, styryllactones and alkaloids1-3 from the genus were reported in the previous literature and many of them showed strong cytotoxic activities against a number of human cancer cell lines4. The titled plant has been the subject of our investigation due to the impressive cytotoxicity of its organic extract against mouse lymphocytic leukemia cells in preliminary pharmacological s…     

Two novel fluorescent calix[4]arene derivatives with benzoazole units in 1,3-alternate conformation for selective recognition to Fe~(3+) and Cr~(3+)

Two novel fluorescent calix[4]arene derivatives 1a and 1b with benzoxazole or benzothiazole units in 1,3-alternate conformation have been synthesized and characterized by IR,~1H NMR,~(13)C NMR and MS.Their complexation properties to different heavy and transition metal ions have been studied by UV-vis spectroscopy and fluorescence spectrometer.Compounds 1a and 1b show selective recognition to Fe~(3+) and Cr~(3+).     

A new macrolide and glycosides from the stem of Sargentodoxa cuneata

A new macrolide glycoside,cuneataside F was isolated from the n-butanol extract of the stem of Sargentodoxa cuneata. The structure was elucidated on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic analysis.     

CO_2 Adducts of the Amino and Imino Groups Studied by ~1HNMR and ~(13)CNMR

When isolating 1,4-dideoxy-1,4-imino-D-arabinitol using Dowex 1(2 (OH- form) or CM-Sephadex C-25 (NH4+ form), we found another compound always accompanied with it. It was apparent that the two compounds had similar structures from their 1HNMR and 13CNMR in D2O (Fig. 1). At first, we guessed the two compounds were isomerides. But when acid was added into the solution of the two compounds, the signals for the minor compound disappeared.Figure 1 13CNMR of 1,4-dideoxy-1,4-imino-D-arabin…     

Synthesis and Crystal Structure of （R）-4-Hydroxymethyl-2-thioxo Thiazolidine and Its Asymmetric Catalysis

(R)-4-Hydroxymethyl-2-thioxo thiazolidine as a new chiral catalyst in the asymmetric addition of diethyl-zinc to benzaldehyde was synthesized from (R)-4-hydroxymethyl-2-thioxo thiazolidine carboxylic acid and its crystal structure was determined by X-ray diffraction method. The compound was crystallized in the orthorhombic system, space group P212121 with unit cell dimensions a=0.67253(12) nm; b=0.89164(17) rim; c=1.06146(19) nm, volume 0.6365(2) nm3; Z=4, calculated denisity 1.557 Mg/m3; absorption coefficient 0.733 mm-1; F(000)=312. The X-ray crystal structure analysis reveals that the compound has a thione group.     

An Efficient Solid-State Synthesis of N-Aryl-2-phenyldiazenecarboxamides

The subject of organic solid-state synthesis is a fascinating one. It has many advantages such as high efficiency and selectivity, easy separation and purification, mild reaction conditions, and environmental acceptability1. In recent years, this method has been widely used in a variety of organic reactions including substitution2, condensation3, oxidation-reduction4, rearrangement5 and elimination6. However, the solid state reaction using K3Fe(CN)6/KOH to oxidize substituted semicarbazides…     

氟代糖的合成

本文综述了氟代糖合成的新进展及利用选择性氟化合成具有生物活性的物质。