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21.
22.
Waveband and dose dependency of sunlight-induced immunomodulation and cellular changes 总被引:1,自引:0,他引:1
Both the UVB and UVA wavebands within sunlight are immunosuppressive. This article reviews the relationship between wavebands and dose in UV-induced immunosuppression mainly concentrating on responses in humans. It also contrasts the effects of UVB and UVA on cellular changes involved in immunosuppression. Over physiological sunlight doses to which humans can be exposed during routine daily living or recreational pursuits, both UVA and UVB suppress immunity. While there is a linear dose relationship with UVB commencing at doses less than half of what is required to cause sunburn, UVA has a bell-shaped dose response over the range to which humans can be realistically exposed. At doses too low for either waveband to be suppressive, interactions between UVA and UVB augment each other, enabling immunosuppression to occur. At doses beyond where UVA is immunosuppressive, it still contributes to sunlight-induced immunosuppression via this interaction with UVB. While there is little research comparing the mechanisms by which UVB, UVA and their interactions can cause immunosuppression, it is likely that different chromophores and early molecular events are involved. There is evidence that both wavebands disrupt antigen presentation and effect T cell responses. Different individuals are likely to have different immunomodulatory responses to sunlight. 相似文献
23.
Diacetyl production via alpha-acetolactic acid (ALA) extracellular decarboxylation inLactococcus lactis spp.lactis bv.diacetylactis SD 933 cultures has been assessed under anaerobiosis both in batch and continuous fermentations at pH 5.5 and 8.0 by studying the effects of alpha-acetolactate decarboxylase (ADC) addition in the culture broth. This enzyme, favoring the formation of acetoin instead of diacetyl, was added extracellularly and did not disturb diacetyl production. Moreover, oxidation experiments on extracellular culture media did not reveal any increase in diacetyl amount caused by extracellular ALA oxidative decarboxylation. These observations confirm previous assertions concerning the mechanism and localization of diacetyl synthesis by theSD 933 strain. 相似文献
24.
I.G. Halliday 《Nuclear Physics B》1976,103(2):343-359
We treat massive electrodynamics as a model for the production of massive μ pairs in high-energy hadronic collisions. The dominant diagrams in perturbation theory are identified and analyzed. These graphs have an eikonal structure which leads to enormous cancellations in the two-particle inclusive cross section but not in the n-particle production cross sections. Under the assumption that these cancellations are complete, a Drell-Yan structure appears in the inclusive cross section but the particles accompanying the μ pairs have a very different structure compared to the parton model. The pionization region is no longer empty of particles as in simple parton models. 相似文献
25.
In this paper, a general framework is developed for determining the underlying parameters of general signal models through the application of maximum likelihood estimation theory for functions whose variables separate. This method extends previous work in sinusoidal and exponential estimation to include models with other functional bases, such as exponential functions with nonconstant amplitudes and Bessel functions. Nonuniform spatial sampling is also possible with this technique. The maximum likelihood method is applied to the identification of wave components along one-dimensional structural elements. Results are given which demonstrate the viability and accuracy of the technique estimating exponential and Bessel function model parameters from noisy simulation data. 相似文献
26.
The phase structure of pure SU(N)/Z(N) lattice gauge theories in four dimensions is discussed. The presence of ZN monopoles plausibly leads to a phase transition. A Monte Carlo simulation of SO(3) shows the presence of a very strong, may be first order, phase transition. 相似文献
27.
Vockenhuber C Oberli F Bichler M Ahmad I Quitté G Meier M Halliday AN Lee DC Kutschera W Steier P Gehrke RJ Helmer RG 《Physical review letters》2004,93(17):172501
The decay of 182Hf, now extinct, into stable 182W has developed into an important chronometer for studying early solar system processes such as the accretion and differentiation of planetesimals and the formation of the Earth and the Moon. The only 182Hf half-life measurements available were performed 40 years ago and resulted in an imprecise half-life of (9+/-2)x10(6) yr. We redetermined the half-life by measuring the specific activity of 182Hf based on two independent methods, resulting in a value of t(1/2)(182Hf)=(8.90+/-0.09)x10(6) yr, in good agreement with the previous value, but with a 20 times smaller uncertainty. The greatly improved precision of this half-life now permits very precise intercalibration of the 182Hf-182W isotopic system with other chronometers. 相似文献
28.
Halliday DM Rosenberg JR Breeze P Conway BA 《IEEE transactions on bio-medical engineering》2006,53(6):1056-1066
A comparison of previously defined spike train syncrhonization indices is undertaken within a stochastic point process framework. The second-order cumulant density (covariance density) is shown to be common to all the indices. Simulation studies were used to investigate the sampling variability of a single index based on the second-order cumulant. The simulations used a paired motoneurone model and a paired regular spiking cortical neurone model. The sampling variability of spike trains generated under identical conditions from the paired motoneurone model varied from 50% to 160% of the estimated value. On theoretical grounds, and on the basis of simulated data a rate dependence is present in all synchronization indices. The application of coherence and pooled coherence estimates to the issue of synchronization indices is considered. This alternative frequency domain approach allows an arbitrary number of spike train pairs to be evaluated for statistically significant differences, and combined into a single population measure. The pooled coherence framework allows pooled time domain measures to be derived, application of this to the simulated data is illustrated. Data from the cortical neurone model is generated over a wide range of firing rates (1-250 spikes/s). The pooled coherence framework correctly characterizes the sampling variability as not significant over this wide operating range. The broader applicability of this approach to multielectrode array data is briefly discussed. 相似文献
29.
ATPG and diagnostics for boards implementing boundary scan 总被引:1,自引:1,他引:0
The emergence of the IEEE 1149.1 boundary scan standard facilitates structured approaches for board partitioning, allowing test generation and execution on localized logic clusters. This article discusses a study conducted on 1149.1 board designs to examine issues associated with board-level Automatic Test-Pattern Generation (ATPG) and diagnostics. 相似文献
30.
Neill WA Halliday KE Norval M 《Journal of photochemistry and photobiology. B, Biology》1998,47(2-3):129-135
Exposure to ultraviolet B (UV-B) light is recognized to induce suppression of certain immune responses, particularly delayed hypersensitivity. However, its effect on cytotoxic T lymphocyte (CTL) activity, of major importance in the resistance to viruses and tumours, has not been assessed to the same extent. In this study five normal subjects, seropositive for herpes simplex virus (HSV), underwent a standard course of broadband UV-B therapy, as used in the treatment of psoriasis. They received whole-body irradiation thrice weekly for four weeks with incremental doses dependent on skin type. Blood samples were taken immediately before, at two time points during, and at the end of the therapy. An HSV-specific CTL assay was performed using autologous B cells transformed with Epstein-Barr virus as targets. No consistent modulation in CTL activity was obtained as a result of the therapy. The CTLs were separated into CD4 and CD8 subsets by positive selection and, again, no effect of irradiation on CTL activity within each of these two populations was observed. In contrast, the natural killer (NK) cell activity, assessed by the lysis of K562 cells, was significantly reduced at the first time point after the initiation of the phototherapy in all five subjects, and it continued to decline as the treatment progressed. Thus a differential effect of UV-B exposure on cytotoxic activity has been demonstrated: the HSV-specific CTL response is unchanged, while the NK response is suppressed. 相似文献