Synthesis and antitumour activity of inositol phosphonate analogues

Inositol phosphates regulate important biological functions in intracellular signal transduction events. Phosphonates, because of the stability towards the action of phosphatases, were extensively used to replace phosphates. We herein reported the synthesis of inositol phosphonate analogues using myo-inositol as the starting material, and found that two of phosphonate analogues exhibited relative good cytotoxic activity against non-small cell lung cancer (NSCLC) cell line A549.     

Polystyrene-bound diethanolamine based ionic liquids for chemical fixation of CO2

Polystyrene-bound diethanolamine based ionic liquids (PS-DHEEAB and PS-THEAB) were synthesized and applied for the chemical fixation of CO₂ into cyclic carbonates without any additional co-catalyst and solvent. The effect of the catalysts with different number of hydroxyl group in the cation of the IL on the reaction was systematically investigated. Highest activity and selectivity were achieved in the presence of polystyrene supported diethanolamine ethyl bromide (PS-DHEEAB) in comparison with other catalysts employed. The catalyst was tough in stability and also found to be extended to a variety of terminal epoxides and aziridines. The relationship between high catalytic reactivity and the –OH functional groups was proposed.     

Synthesis of mikto‐topology star polymer containing one cyclic arm

Well‐defined mikto‐topology star polystyrene composed of one cyclic arm and four linear arms was synthesized by a combination of atom transfer radical polymerization (ATRP) and Cu‐catalyzed azide‐alkyne cycloaddition (CuAAC) click reaction. First, the bromine‐alkyne α,ω‐linear polystyrenes containing four hydroxyl groups protected with acetone‐based ketal groups were synthesized by ATRP of styrene using a designed initiator. Then, the bromine end‐group was converted to the azide and the linear polystyrene was cyclized intra‐molecularly by the CuAAC reaction. The four hydroxyl groups were released by deprotection and then esterified with 2‐bromoisobutyryl bromide to produce a cyclic polymer bearing four ATRP initiating units. By subsequent ATRP of styrene to grow linear polymers with the cyclic polystyrene as a macroinitiator, the mikto‐topology star polymers were prepared. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012     

Copper‐catalyzed Clauson–Kass pyrroles synthesis in aqueous media

An efficient and convenient copper‐catalyzed Clauson–Kass reaction of 2,5‐dimethoxytetrahydrofuran with amines in aqueous media has been developed, providing a wide range of N‐substituted pyrroles in good yields. It is noteworthy that the Clauson–Kass reaction of 2,5‐dimethoxytetrahydrofuran with p‐phenylenediamine or m‐phenylenediamine proceeds smoothly to afford the corresponding monopyrroles and bispyrroles with high selectivity in impressive yields. A plausible mechanism for the formation of N‐substituted pyrroles has been proposed. Copyright © 2012 John Wiley & Sons, Ltd.     

无限长黑圆柱情形下密恩(Milne)问题的近似解(球谐函数展开法)

本文探讨当一无限长黑圆柱放在一满足密恩问题中诸条件的无限介质中时,介质中的中子分布。计算采用球谐函数展开法,把中子分布函数对球谐函数展开,保留展开式的起首若干项,从而求得近似解。具体计算作到P₅近似为止。表2及附图示各次近似中对於圆柱半径α的不同值求出的外推长度λ之值。作为长度单位的是中子在介质中的平均自由路程l。为比较起见,我们在图中也画出了达维逊(Davison)给出的曲线(曲线D)。他的曲线是根据α《1及α》1二极限情形下派耳斯(Peierls)积分方程的近似解,中间参照P₃近似的结果画出的。由图可见,α大时P₅近似的结果已很接近於曲线D,而在α=1附近,则曲线D似乎远应该略低一些,才更符合曲线P₅的趋势(例如,像图中虚线所表示的那样)。     

矢志创新铸辉煌,壮心不已续华章——贺李启虎院士八十华诞

2019年7月11日,我们迎来了李启虎先生的八十华诞。先生是水声信号处理和声呐设计领域享誉世界的专家、中国科学院院士,曾任中国科学院声学研究所所长、国家“863”计划海洋监测主题专家组组长、总装备部国家重大安全项目专家组组长。他长期从事信号处理理论研究和声呐设计、研制工作,结合我国浅海声传播的特点,创造性地应用信息论、数字信号处理、水声工程等理论,解决了一系列水声信号处理中的问题,为我国国防水声事业及国家信息化建设做出了突出的贡献。     

TBAB包络化合物浆的管内流动再层流化现象

TBAB包络化合物浆是一种新型高密度潜热输送材料,在中央空调或区域供冷等系统中作为替代常规冷水的冷量输送媒体具有显著的节能应用前景.采用实验方法研究了A型TBAB包络化合物浆在水平直管内的层流和湍流流动特性.通过分析流动阻力随流速和固相含量等参数的变化规律,发现固相含量的增加有利于维持流动的层流趋势,在定流速条件下随着固相含量的增加流动状态会由湍流转变为层流,即出现"再层流化"现象,并且由于再层流化现象的出现,包络化合物浆的流动会出现"阻力降低区".     

一种用于2维数据访问的缓存管理算法

2维数据以1维的形式进行处理和存储,2维空间相邻的节点被不同的映射算法映射到1维空间的不同位置.不同位置导致了不同的访问距离和访问延迟.提出了度量访问距离的指标,计算了4种主要映射算法的指标值,发现并分析了不同算法指标值之间的差异.通过在缓存中增加用于预取的空间,利用了Z-ordering和Hilbert映射算法在一定范围内能更好地簇集映射位置的特性,提高了缓存命中率,从而改善了2维数据的访问速度,优化了系统性能.