全文获取类型
收费全文 | 291篇 |
免费 | 8篇 |
专业分类
化学 | 210篇 |
晶体学 | 4篇 |
力学 | 2篇 |
数学 | 41篇 |
物理学 | 34篇 |
无线电 | 8篇 |
出版年
2023年 | 3篇 |
2022年 | 16篇 |
2021年 | 12篇 |
2020年 | 9篇 |
2019年 | 12篇 |
2018年 | 2篇 |
2017年 | 11篇 |
2016年 | 8篇 |
2015年 | 5篇 |
2014年 | 7篇 |
2013年 | 24篇 |
2012年 | 17篇 |
2011年 | 12篇 |
2010年 | 10篇 |
2009年 | 4篇 |
2008年 | 14篇 |
2007年 | 12篇 |
2006年 | 19篇 |
2005年 | 11篇 |
2004年 | 11篇 |
2003年 | 12篇 |
2002年 | 3篇 |
2001年 | 1篇 |
2000年 | 4篇 |
1999年 | 4篇 |
1998年 | 7篇 |
1997年 | 5篇 |
1996年 | 6篇 |
1995年 | 4篇 |
1993年 | 4篇 |
1992年 | 2篇 |
1991年 | 5篇 |
1989年 | 2篇 |
1988年 | 6篇 |
1987年 | 1篇 |
1986年 | 6篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1978年 | 2篇 |
排序方式: 共有299条查询结果,搜索用时 15 毫秒
11.
Pablo R. Beltrán Juan Miguel Gil Rafael Rodríguez Guadalupe Espinosa Manuel D. Barriga-Carrasco 《X射线光谱测定》2020,49(1):173-176
The purpose of this work is to study the interaction between an ion beam and a doped deuterium-tritium (DT) plasma in a fast ignition nuclear fusion context. In order to analyze the influence of the dopants in the interaction process, we present a physical model to carry out spatial-temporal simulations of the stopping of an ion beam interacting with a doped plasma target, the plasma heating processes, and the formation of the ignition regions. We perform a set of numerical experiments where different concentrations of dopants are added to a fully ionized DT plasma. These simulations allow us to characterize the increase in the stopping power and the maximum temperatures achieved with the presence of impurities, as well as the reduction of the heated and ignition regions. This reduction in the ignition region indicates difficulties for the formation of an efficient hot spot when there are dopants in the DT plasma. 相似文献
12.
M.?Bello HernándezEmail author B.?de la?Calle Ysern J.?J.?Guadalupe Hernández G.?Lopez Lagomasino 《Journal d'Analyse Mathématique》2002,86(1):1-23
We study the asymptotic properties of Stieltjes polynomials outside the support of the measure as well as the asymptotic behaviour of their zeros. These properties are used to estimate the rate of convergence of sequences of rational functions, whose poles are partially fixed, which approximate Markovtype functions. An estimate for the speed of convergence of the Gauss-Kronrod quadrature formula in the case of analytic functions is also given. 相似文献
13.
X-Ray crystallography showed that the heterocyclic ring of 1a and 1d is a chair with the substituents intermediate between axial and equatorial (all cis) and diequatorial-monoaxial (two cis and one trans) positions, respectively. Infrared NS absorption in solid and solution led to tentative stereochemieal assignments for 1a-d. 相似文献
14.
Karadeniz-Bilgili MY Semelka RC Hyslop WB Pamuklar E Rivero H Firat Z Woosley JT 《Magnetic resonance imaging》2005,23(3):515-517
We report the MRI findings of primary small-cell carcinoma of the kidney (PSCCK) in a 59-year-old female. This tumor appeared as a 16-cm mass that arose from the right kidney. This lesion had diminished signal on T1-weighted images and heterogeneous mixed signal on T2-weighted images. The tumor primarily involved the renal medulla with persistent thin renal cortex. Despite the tumors' large size, no substantial central necrosis was present. The predominant medullary location and the lack of central necrosis in this large tumor were features unusual for renal cell carcinoma and should raise the suspicion of another malignancy, the differential diagnosis of which should contain extrapulmonary small-cell carcinoma of the kidney. 相似文献
15.
Rodríguez Rivero M De La Rosa JC Carretero JC 《Journal of the American Chemical Society》2003,125(49):14992-14993
The first asymmetric version of intermolecular Pauson-Khand reactions of unstrained alkenes is described. Generally simple acyclic alkenes exhibit low reactivity and regioselectivity in intermolecular Pauson-Khand reactions; however, o-(dimethylamino)phenyl vinyl sulfoxide reacts under very mild conditions with a wide variety of terminal alkynes in a completely regioselective and highly stereoselective manner. The utility of the resulting 5-sulfinyl-2-cyclopentenones in asymmetric synthesis is illustrated by a very short enantioselective synthesis of the antibiotic (-)-pentenomycin I. 相似文献
16.
Effectiveness of Photodynamic Therapy in Elimination of HPV‐16 and HPV‐18 Associated with CIN I in Mexican Women 下载免费PDF全文
Elizabeth Maldonado Alvarado Martha Olivia Osorio Peralta Alejandra Moreno Vázquez Lydia Alejandra Martínez Guzmán Maria Eugenia Melo Petrone Zulma Iveth Enriquez Mar Dora Estela Jovel Galdamez Bárbara Carrión Solana Guadalupe Balderas Martínez Eduarda Parra Rossana Inés Castellanos Oliveros Rosa Linda Bello Leiva Araceli Espinosa Montesinos Citlalli Barrera Mendoza Selma Eugenia Medina García Eva Ramón Gallegos 《Photochemistry and photobiology》2017,93(5):1269-1275
This study aimed to determine the effectiveness of photodynamic therapy (PDT), using δ‐aminolevulinic acid (5‐ALA), in the elimination of premalignant cervical lesions in Mexican patients with human papillomavirus (HPV) infection and/or cervical intraepithelial neoplasia (CIN). Thirty women diagnosed with CIN I and/or positive for HPV participated in the study. Topical 6% 5‐ALA in gel form was applied to the uterine cervix; after 4 h, the lesion area was irradiated with a light dose of 200 J cm?2 at 635 nm. This procedure was performed three times at 48‐h intervals. Clinical follow‐up was performed at 3, 6, and 12 months after the initial PDT administration, by colposcopy, cervical cytology, histopathological analysis, polymerase chain reaction, and hybrid capture. Of HPV‐infected patients without evidence of CIN I, 80% cleared the infection, while HPV associated with CIN I was eliminated in 83% of patients (P < 0.05). At 12 months, CIN I had regressed in 57% of patients, although this response was not statistically significant. PDT using 6% 5‐ALA is concluded to be effective in eliminating HPV infection associated or not with CIN I. 相似文献
17.
Guadalupe Valverde-Aguilar Jorge A. García-Macedo Víctor M. Rentería-Tapia Raúl W. Gómez Manuel Quintana-García 《Journal of nanoparticle research》2011,13(10):4613-4622
Hexagonal mesostructured films containing silver ions were obtained by sol–gel method. Brij 58 was used to produce channels
into the film, which house these ions. The films were exposure to UV radiation to produced silver metallic nanoparticles.
The presence of the metallic nanoparticles was determined by infrared spectroscopy and optical absorption. Besides, these
nanoparticles and core–shell structures of silver–silver oxide nanoparticles were identified by high-resolution transmission
electronic microscopy. From these measurements, the obtained size range for silver nanoparticles was 6.1 nm. The absorption
spectrum located at 440 nm was modelled and well fitted with the Gans theory considering refractive index higher than the
one coming from host matrix. This index is explained because the silver oxide shell modifies the local surrounding medium
of the metallic nanoparticles. 相似文献
18.
The title compound (C7H8N2O2), is monoclinic, space group P21/n, witha=9.552(2),b=5.677(2),c=13.586(3)Å, =92.68(2)0, andD
x=1.374 g-cm–3 forZ=4. The refinement converged toR=0.043,wR=0.038. The molecule is approximately planar, with dihedral angles of 3.7(2.1)0 between the amino group and the aromatic ring, and 3.2(2)0 between the nitro group and the ring. According to the UV spectrum in solution, the molecular geometry indicates weak intramolecular charge transfer. The three-dimensional structure is stabilized by three intermolecular H bonds. A bifurcated one induces the formation of chains along
, while the other two link molecules that belong to adjacent chains and are related by an inversion center. 相似文献
19.
Lockard JV Valverde G Neuhauser D Zink JI Luo Y Weaver MN Nelsen SF 《The journal of physical chemistry. A》2006,110(1):57-66
Excited state mixed valence (ESMV) occurs in molecules in which the ground state has a symmetrical charge distribution but the excited state possesses two or more interchangeably equivalent sites that have different formal oxidation states. Although mixed valence excited states are relatively common in both organic and inorganic molecules, their properties have only recently been explored, primarily because their spectroscopic features are usually overlapped or obscured by other transitions in the molecule. The mixed valence excited state absorption bands of 2,3-di-p-anisyl-2,3-diazabicyclo[2.2.2]octane radical cation are well-separated from others in the absorption spectrum and are particularly well-suited for detailed analysis using the ESMV model. Excited state coupling splits the absorption band into two components. The lower energy component is broader and more intense than the higher energy component. The absorption bandwidths are caused by progressions in totally symmetric modes, and the difference in bandwidths is caused by the coordinate dependence of the excited state coupling. The Raman intensities obtained in resonance with the high and low energy components differ significantly from those expected based on the oscillator strengths of the bands. This unexpected observation is a result of the excited state coupling and is explained by both the averaging of the transition dipole moment orientation over all angles for the two types of spectroscopies and the coordinate-dependent coupling. The absorption spectrum is fit using a coupled two-state model in which both symmetric and asymmetric coordinates are included. The physical meaning of the observed resonance Raman intensity trends is discussed along with the origin of the coordinate-dependent coupling. The well-separated mixed valence excited state spectroscopic components enable detailed electronic and resonance Raman data to be obtained from which the model can be more fully developed and tested. 相似文献
20.
Edgardo Becerra Giovanny Aguilera-Durn Laura Berumen Antonio Romo-Mancillas Guadalupe García-Alcocer 《Molecules (Basel, Switzerland)》2021,26(4)
Multidrug resistance protein-4 (MRP4) belongs to the ABC transporter superfamily and promotes the transport of xenobiotics including drugs. A non-synonymous single nucleotide polymorphisms (nsSNPs) in the ABCC4 gene can promote changes in the structure and function of MRP4. In this work, the interaction of certain endogen substrates, drug substrates, and inhibitors with wild type-MRP4 (WT-MRP4) and its variants G187W and Y556C were studied to determine differences in the intermolecular interactions and affinity related to SNPs using protein threading modeling, molecular docking, all-atom, coarse grained, and umbrella sampling molecular dynamics simulations (AA-MDS and CG-MDS, respectively). The results showed that the three MRP4 structures had significantly different conformations at given sites, leading to differences in the docking scores (DS) and binding sites of three different groups of molecules. Folic acid (FA) had the highest variation in DS on G187W concerning WT-MRP4. WT-MRP4, G187W, Y556C, and FA had different conformations through 25 ns AA-MD. Umbrella sampling simulations indicated that the Y556C-FA complex was the most stable one with or without ATP. In Y556C, the cyclic adenosine monophosphate (cAMP) and ceefourin-1 binding sites are located out of the entrance of the inner cavity, which suggests that both cAMP and ceefourin-1 may not be transported. The binding site for cAMP and ceefourin-1 is quite similar and the affinity (binding energy) of ceefourin-1 to WT-MRP4, G187W, and Y556C is greater than the affinity of cAMP, which may suggest that ceefourin-1 works as a competitive inhibitor. In conclusion, the nsSNPs G187W and Y556C lead to changes in protein conformation, which modifies the ligand binding site, DS, and binding energy. 相似文献