Adsorption of Large Organic Molecules on Clean and Hydroxylated Rutile TiO2(110) Surfaces

Behavior of large organic molecules equipped with spacer groups (Violet Landers, VL) on the TiO₂(110)‐(1×1) surfaces is investigated by means of high‐resolution scanning tunneling microscopy (STM). Two distinct adsorption geometries are observed. We demonstrate that the molecule adsorption morphology can be alternated by well‐controlled STM tip‐induced manipulation. It is used to probe the mobility of molecules and reveals locking in one of the analyzed adsorption sites, thus allow to enhance or reduce the mobility along the [001] direction. Field induced hydrogen desorption is used to perform lateral STM manipulation on a hydroxyl‐free surface, which provides insight into the influence of surface hydroxyl groups on the molecule behavior. The ability to image with submolecular resolution both the central board and the spacer groups of the VL molecule is demonstrated.     

Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects

The enzyme fatty acid amide hydrolase (FAAH) catalyzes the in vivo degradation of the endocannabinoid anandamide, thus controlling its action at receptors. A novel FAAH inhibitor, AM3506, normalizes the elevated blood pressure and cardiac contractility of spontaneously hypertensive rats (SHR) without affecting these parameters in normotensive rats. These effects are due to blockade of FAAH and a corresponding rise in brain anandamide levels, resulting in CB? receptor-mediated decrease in sympathetic tone. The supersensitivity of SHR to CB? receptor-mediated cardiovascular depression is related to increased G protein coupling of CB? receptors. Importantly, AM3506 does not elicit hyperglycemia and insulin resistance seen with other FAAH inhibitors or in FAAH?/? mice, which is related to its inability to inhibit FAAH in the liver due to rapid hepatic uptake and metabolism. This unique activity profile offers improved therapeutic value in hypertension.     

Far field emission of micropillar and planar microcavities lattice-matched to ZnTe

We investigate light emission from ZnTe-based microcavities containing CdTe quantum dots (QDs), with 2D (planar cavity) and 0D (pillar cavities) photonic confinement. The angular distribution from the planar cavity is presented as well as 2D cross-sections of the far field distribution of radiation from the micropillars. The efficient and desirable modification of the isotropic radiation of the QDs is shown for such structures. The diffraction observed is found to be inherent for such experiments with large numerical aperture of the lens and small diameters of the investigated pillars. This diffraction is successfully modeled.     

Multicellular Alamouti scheme performance in Rayleigh and shadow fading

In this paper, we study the performance of two downlink multicellular systems: a multiple inputs single output (MISO) system using the Alamouti code and a multiple inputs multiple outputs (MIMO) system using the Alamouti code at the transmitter side and a maximum ratio combining (MRC) as a receiver, in terms of outage probability. The channel model includes path-loss, shadowing, and fast fading, and the system is considered interference-limited. Two cases are distinguished: constant shadowing and log-normally distributed shadowing. In the first case, closed form expressions of the outage probability are proposed. For a log-normally distributed shadowing, we derive easily computable expressions of the outage probability. The proposed expressions allow for fast and simple performance evaluation for the two multicellular wireless systems: MISO Alamouti and MIMO Alamouti with MRC receiver. We use a fluid model approach to provide simpler outage probability expressions depending only on the distance between the considered user and its serving base station.     

Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia

Alcohol consumption is associated with gut dysbiosis, increased intestinal permeability, endotoxemia, and a cascade that leads to persistent systemic inflammation, alcoholic liver disease, and other ailments. Craving for alcohol and its consequences depends, among other things, on the endocannabinoid system. We have analyzed the relative role of central vs. peripheral cannabinoid CB1 receptors (CB1R) using a “two-bottle” as well as a “drinking in the dark” paradigm in mice. The globally acting CB1R antagonist rimonabant and the non-brain penetrant CB1R antagonist JD5037 inhibited voluntary alcohol intake upon systemic but not upon intracerebroventricular administration in doses that elicited anxiogenic-like behavior and blocked CB1R-induced hypothermia and catalepsy. The peripherally restricted hybrid CB1R antagonist/iNOS inhibitor S-MRI-1867 was also effective in reducing alcohol consumption after oral gavage, while its R enantiomer (CB1R inactive/iNOS inhibitor) was not. The two MRI-1867 enantiomers were equally effective in inhibiting an alcohol-induced increase in portal blood endotoxin concentration that was caused by increased gut permeability. We conclude that (i) activation of peripheral CB1R plays a dominant role in promoting alcohol intake and (ii) the iNOS inhibitory function of MRI-1867 helps in mitigating the alcohol-induced increase in endotoxemia.     

Photoresistor based on ZnO nanorods grown on a p-type silicon substrate

In this work we discuss a method of preparation of a highly sensitive light detector based on ZnO nanorods. A photoresistor constructed by us is based on a heterojunction between high quality ZnO nanorods and high resistivity p-type Si used as a substrate for nanorods’ deposition. ZnO nanorods are grown by a modified version of a microwave assisted hydrothermal method which allows for growth of high quality ZnO nanorods in a few minutes. The obtained photoresistor responds to a wide spectral range of light starting from near infrared (IR) to ultraviolet (UV). Properties of the detector are evaluated. We propose the use of the detector as an optical switch.     

Interstitial Mn as a new donor in GaP and GaAs: an EPR study

We report the observation of a new electron paramagnetic resonance centre in neutron-irradiated GaP and a similar new EPR centre in Mn-doped GaAs. Both centres have been identified as interstitial Mn and act as a donor. To our knowledge this is the first observation by EPR of an interstitial transition-metal impurity in a III-V compound. The implication of this new finding on the issue of Mn diffusion is discussed.     

Key-minimal cryptosystems for unconditional secrecy

This paper is concerned with cryptosystems offering perfect or unconditional secrecy. For those perfect-secrecy systems which involve using keys just once, the theory is well established; however, this is not the case for those systems which involve using a key several times. This paper takes a rigorous approach to the definition of such systems, and exhibits some new families of examples of systems providing perfect secrecy for which the number of keys is minimal.