Stemmosides C and D, two novel unusual pregnane glycosides from Solenostemma argel: structural elucidation and configurational study by a combined NMR-quantum mechanical strategy

Stemmosides C and D, two novel pregnane glycosides characterized by an unusual C-17 side chain were isolated from the pericarps of Solenostemma argel. In addition, stemmoside D displays an uncommon 14β proton configuration, apparently being the first pregnane isolated from plants known to have a 15 keto, cis CD ring junction. Their structures have been established by ESIMS and NMR experiments. The relative configuration of the molecules was determined using a strategy based on the simulation of ¹H, ¹³C, and J coupling NMR parameters. DFT calculations of ¹H and ¹³C chemical shifts, and of the ¹H homonuclear spin–spin coupling constants were performed with the mPW1PW91 functional using the 6-31G(d,p) basis set on the fully optimized geometries of all the possible stereoisomers.     

Regularity of minima: An invitation to the dark side of the calculus of variations

I am presenting a survey of regularity results for both minima of variational integrals, and solutions to non-linear elliptic, and sometimes parabolic, systems of partial differential equations. I will try to take the reader to the Dark Side... This work has been partially supported by MIUR via the project “Calcolo delle Variazioni” (Cofin 2004), and by GNAMPA via the project “Studio delle singolarità in problemi geometrici e variazionali”.     

Lie-Poincaré transformations and a reduction criterion in Landau theory

In the Landau theory of phase transitions one considers an effective potential Φ whose symmetry group G and degree d depend on the system under consideration; generally speaking, Φ is the most general G-invariant polynomial of degree d. When such a Φ turns out to be too complicate for a direct analysis, it is essential to be able to drop unessential terms, i.e., to apply a simplifying criterion. Criteria based on singularity theory exist and have a rigorous foundation, but are often very difficult to apply in practice. Here we consider a simplifying criterion (as stated by Gufan) and rigorously justify it on the basis of classical Lie-Poincaré theory as far as one deals with fixed values of the control parameter(s) in the Landau potential; when one considers a range of values, in particular near a phase transition, the criterion has to be accordingly partially modified, as we discuss. We consider some specific cases of group G as examples, and study in detail the application to the Sergienko-Gufan-Urazhdin model for highly piezoelectric perovskites.     

Synthesis of potential selective cox‐2 enzyme inhibitors derived from ethyl ester of 2‐isothiocyanato‐5‐phenyl‐3‐thiophenecarboxylic acid

Derivatives containing the thieno[2,3‐d]pyrimidin‐4‐one system, potential selective COX‐2 inhibitors, were prepared starting from ethyl ester of 2‐isothiocyanato‐5‐phenyl‐3‐thiophenecarboxylic acid ( 2 ); their structural elucidation is also reported.     

Low-Power Adaptive Biased Integrated Amplifiers

In this paper the author will present the working principle and the applications of a novel adaptive biasing topology, designed to decrease the stand-by power dissipation without affecting the transient performance of low-power amplifiers. The proposed circuit, whose principle and circuit topology can be implemented both in CMOS and in bipolar standard technologies, gives a biasing current whose value depends on the applied input differential voltage and can be set according to the requested transient performance constraints. The adaptive architecture can be utilized in the design of high-efficient low-power operational amplifiers, for the biasing of both the input stage (where the input source current is dynamically increased) and the output stage (where the output current can be controlled and limited). These amplifiers show a very good behaviour, evaluated in terms of two efficiency factors, if compared with those of other adaptive solutions and class-AB topologies, proposed in the literature. Simulation results and also measurements on a chip prototype, fabricated in a standard CMOS technology, are finally presented.     

Existence and Ergodicity for the Two-Dimensional Stochastic Magneto-Hydrodynamics Equations

The paper proves the existence of solutions to the magneto-hydrodynamics equations driven by random exterior forcing terms both in the velocity and in the magnetic field. The existence and uniqueness of an invariant measure is also obtained via coupling methods.     

Cohomology and extension problems for semi <Emphasis Type="Italic">q</Emphasis>-coronae

We prove some extension theorems for analytic objects, in particular sections of a coherent sheaf, defined in semi q-coronae of a complex space. Semi q-coronae are domains whose boundary is the union of a Levi flat part, a q-pseudoconvex part and a q-pseudoconcave part. Such results are obtained mainly using cohomological techniques.