A simple and efficient procedure for the synthesis of optically active s-triazolothiadiazole derivatives

A series of novel s-triazolothiadiazoles 3a-h were prepared by condensation reaction of substituted amino triazoles la-b with N-phethaloyl-L-amino acids 2a-d in the presence of the phosphoroxy chloride（POCl₃） as an anhydrous reagent.The structure of all synthesized compounds was confirmed by IR,¹H NMR,and ¹³C NMR spectroscopy.     

The clean and mild synthesis,crystal structure,and intra-molecular hydrogen bond study of substituted new 4,8-dihydropyrano[3,2-b]-pyrans containing chlorokojic acid moiety

Research on Chemical Intermediates - A safe, green and convenient process was developed for the synthesis of a novel group of 4,8-dihydropyrano[3,2-b]-pyrans by dialkyl acetylenedicarboxylates and...     

A promising electrochemical sensing platform based on copper nanoparticles-decorated polymer in carbon nanotube electrode for monitoring methimazole

In this paper, a novel and convenient electrochemical sensor for detection of methimazole (MMI) by differential pulse voltammetry is presented. This sensor was fabricated by dripping well-dispersed MWCNTs onto glassy carbon electrode (GCE) surface, and then poly-l-Arg (P-L-Arg) film was deposited on the electrode. Finally, Cu nanoparticles (CuNPs) were electrochemically deposited on the resulting film by using cyclic voltammetry to prepare CuNPs-P-L-Arg/MWCNTs/GCE. The surface morphology of the electrodes has been studied by scanning electron microscopy. Studies reveal that the irreversible oxidation of MMI was highly facile on CuNPs-P-L-Arg/MWCNTs/GCE. The dynamic detection range of this sensor to MMI was 5.2–50 µM, with the detection limit of 2 µM. A new voltammetric method for determination of MMI was erected and shows good sensitivity and selectivity, very easy surface update and good stability. The analytical application of the modified electrode is demonstrated by determining MMI in biological fluids (serum).     

Binding properties of adenosine deaminase interacted with theophylline

Thermodynamic studies were carried out to evaluate the binding of theophylline on adenosine deaminase (ADA) in 50 mM sodium phosphate buffer pH 7.5, at 300 K, using isothermal titration calorimetry (ITC). A simple method for determination of binding isotherm in the drug--ADA interaction was applied using ITC data. ADA has two binding sites for theophylline, which show positive cooperativity in its sites. The intrinsic association equilibrium constants are 6 and 52 mM(-1) in the first and second binding sites, respectively. Hence, occupation of the first site has produced an appreciable enhancement by 8.7 of the binding affinity of the second site. The molar enthalpies of binding are -12.2 and -14.9 kJ/mol in the first and second binding sites, respectively.     

Infinitely many weak solutions for p(x)-Laplacian-like problems with Neumann condition

The paper studies the existence of infinitely many solutions for a Neumann problem involving the p(x)-Laplacian-like depending on two parameters. Our approach is based on variational methods.     

Classification of normal/abnormal PCG recordings using a time–frequency approach

The early and accurate diagnosis of cardiovascular diseases (CVDs) are of great importance as they allow early and proper medical treatment and therefore result in reducing the chance of the CVDs being developed to an acute level. In medical procedures, the first step in examining the cardiovascular function is the auscultation of the heart. However, the correct medical diagnosis based on the heart sounds through a stethoscope requires a lot of expertise and, in some cases, needs referral of the patient to a cardiologist. This is not only time-consuming but also imposes a financial burden on the medical system. Thus, automated detection and analysis of the recorded heart sound auscultation has received a lot of attentions in recent years. This study presents a new time–frequency (T–F) based approach for classifying phonocardiogram (PCG) signals into normal and abnormal. In the proposed methodology, each PCG recording is first segmented into the 4 fundamental heart cycles, i.e. S1, systole, S2, and diastole. From each state, a set of T–F features are extracted with the aim of identifying their characteristics in the T–F domain. The features are then applied to a support vector machine to classify the PCG signal into normal or abnormal. The performance of the proposed method is evaluated using the 2016 PhysioNet challenge database and compared with that of the best performing existing methods. The experimental results using tenfold cross-validation show that the proposed method outperforms the existing methods in terms of sensitivity, specificity, and accuracy.

     

Solvent-Free Conditions as an Eco-Friendly Strategy for Synthesis of Organophosphorus Compounds

A series of diverse NH- and CH-acids are used for a one-pot synthesis of stable phosphorus ylides and 1,4-diionic organophosphorus compounds by trapping of the zwitterionic intermediate from the reaction between triphenylphosphine and dialkyl acetylenedicarboxylates under solvent-free conditions. The structural geometry for one of the products was confirmed by single crystal X-ray diffraction analysis.

Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.     

A compensated PID active queue management controller using an improved queue dynamic model

Beside the major objective of providing congestion control, achieving predictable queuing delay, maximizing link utilization, and robustness are the main objectives of an active queue management (AQM) controller. This paper proposes an improved queue dynamic model while incorporating the packet drop probability as well. By applying the improved model, a new compensated PID AQM controller is developed for Transmission Control Protocol/Internet Protocol (TCP/IP) networks. The non‐minimum phase characteristic caused by Padé approximation of the network delay restricts the direct application of control methods because of the unstable internal dynamics. In this paper, a parameter‐varying dynamic compensator, which operates on tracking error and internal dynamics, is proposed to not only capture the unstable internal dynamics but also reduce the effect of uncertainties by unresponsive flows. The proposed dynamic compensator is then used to design a PID AQM controller whose gains are obtained directly from the state‐space representation of the system with no further gain tuning requirements. The packet‐level simulations using network simulator (ns2) show the outperformance of the developed controller for both queuing delay stability and resource utilization. The improved underlying model leads also to the faster response of the controller. Copyright © 2013 John Wiley & Sons, Ltd.     

Efficient Oxidation of Hantzsch 1,4-Dihydropyridines with Tetrabutylammonium Peroxomonosulfate Catalyzed by Manganese(III) Schiff Base Complexes: The Effect of Schiff Base Complex on the Product Selectivity

Efficient and rapid oxidation of Hantzsch 1,4-dihydropyridine with tetrabutylammonium peroxomonosulfate (TBAO) is reported. The Mn(salophen)/monopersulfate catalytic system efficiently converts 1,4-dihydropyridines (DHPs) to their corresponding pyridine derivatives under mechanical stirring and microwave irradiation in CH₂Cl₂. The ability of various Schiff base complexes to oxidize DHPs was also investigated. The results showed that in the presence of manganese Schiff complex, no by-product was obtained.