发光二极管应用于光动力学疗法的可行性分析

讨论了发光二极管(Light-emitting-diode,LED)在航天医学中作为激光器的替代光源用于光动力学疗法(Photodynamic therapy,PDT)的可行性。分析了发光二极管用于光动力学疗法的优势,介绍了LED用于不同类型光敏剂进行PDT治疗的实验研究,概括了LED-PDT治疗系统在国内外的研制现状。说明了LED替代激光器作为PDT的激发光源是可行的。LED作为我国航天医学领域中的一种重要光源,为维护航天员的健康将会发挥重要作用。     

雷电通道水平电场影响因素分析

影响雷电通道产生的水平电场因素众多,分析其影响因素对电力系统的雷电防护具有重要意义。文中利用运动电荷电磁场方程求解得到闪电回击通道的水平电场和方位磁场,并结合C-R 算法,得到了有限电导率地面上方的水平电场。依据运动电荷电磁场方程的特征分析了不同回击速度、不同距离、不同电导率对雷击产生的水平电场的影响。得出以下结论:水平电场随回击速度增大而减小;水平电场波形呈双极性特征且水平距离越大或电导率越小负向偏移越明显。这些研究结论为输电线路雷电过电压计算打下良好的基础。与其他方法相比,本文方法可以避免远距离电磁场计算中的震荡问题和积分方程的奇异问题。     

基于STM32的开环霍尔电流传感器的温度补偿研究

研究了一种基于软件补偿结合恒流源补偿的改进温度补偿方法,应用单片机、恒流源、数字温度传感器、乘法器等硬件电路,对传统软件补偿进行了优化,补偿效果较传统恒流源补偿有了明显提升,“温漂”整体下降了约13.7%。在传统的温度补偿方法如热敏元件补偿、恒流源补偿、软件补偿等方式上做了补充,对于霍尔电流传感器精度的提升及实际生产需求的满足有重要意义。     

Metabolomics study on promoting blood circulation and ameliorating blood stasis: Investigating the mechanism of Angelica sinensis and its processed products

Angelica sinensis (Danggui, DG) parched with alcohol (Jiu Danggui, JDG) and charred DG are the main processed products of DG, which are used to treat blood stasis syndrome (BSS). However, their therapeutic effect and mechanisms are still unclear. Based on an acute rat BSS model, the intervention effects of DG and its processed products (DGPPs) were evaluated by the hemorheology and coagulation function parameters. Meanwhile, plasma and urine metabolites were detected and analyzed by liquid chromatography coupled to quadrupole time‐of‐flight mass spectrometry and multivariate statistical analysis method. The results of hemorheology, coagulation function parameters and metabolomics all showed that the BSS model was successfully established, DGPPs intervention could significantly relieve rats BSS and the therapeutic effect of JDG was best. Moreover, 23 differential metabolites (14 in plasma and nine in urine) were identified that were closely related to the BSS, involving seven potential target metabolic pathways. DGPP intervention showed different degrees of reverse effect on these metabolites. JDG was the most effective owing to extensive regulation effect on differential metabolites. This study provides a reference for understanding the pathological mechanism of BSS and the mechanism of DGPPs, which lays a theoretical foundation for the rational use of DGPPs in clinical practice.     

基于SBS超短脉冲激光器的介质研究

皮秒激光器在众多领域中都有广泛的应用,将纳秒量级激光器脉冲压缩至皮秒量级超短脉冲是目前获得高能量皮秒脉冲激光的常见方法之一。而基于布里渊散射(Stimulated Brillouin Scattering)的脉冲压缩系统结构简单,造价较低,是近年来较为热门的技术手段。布里渊散射脉冲压缩方案的技术关键在于介质研究。本文通过研究目前获得应用的三类介质的化学性能、物理特性以及压缩效果等,对比国内外研究现状,分析了受激布里渊散射对介质的要求以及未来的发展方向。     

四个Cd(Ⅱ)配位聚合物:辅助配体对晶体结构以及荧光性能的影响

采用溶剂热的方法,将配位模式丰富的多羧酸有机配体5-(2-硝基-4-羧基苯氧基)-间苯二甲酸(H3ncpoi)与Cd~(2+)离子以及不同的辅助配体原位组装而成4个新的配位聚合物晶体:[Cd(Hncpoi)(2,2′-bpy)(H2O)]n(1),{[Cd2(Hncpoi)2(bpyp)(H2O)4]·3H2O}n(2),{[Cd2(Hncpoi)2(azpy)(H2O)2]·2H2O}n(3),{[Cd2(Hncpoi)2(dpe)(H2O)2]·2H2O}n(4),其中H3ncpoi为5-(2-硝基-4-羧基苯氧基)-间苯二甲酸,2,2′-bpy为2,2′-联吡啶,bpyp为1,4-二-吡啶基-4-亚甲基-哌嗪,azpy为4,4′-偶氮吡啶,dpe为1,2-二-(4-吡啶基)乙烯。对4个配合物进行了X射线单晶衍射、粉末衍射,元素分析、热重、荧光光谱等表征。X射线单晶结构分析表明,配合物1,2具有一维链状结构,而配合物3,4则具有二维(4,4)格子层状结构,一维链和二维层之间通过分子间作用力连接成三维超分子结构。进一步研究表明,辅助配体的构型、配位方式等对晶体结构具有决定性作用。与此同时,对几个配合物的荧光光谱进行分析,发现不同的辅助配体对配合物的荧光性能有着显著的影响。     

密胺餐具中重金属铅、镉的风险评估研究

以密胺餐具为研究对象,模拟研究密胺餐具中重金属铅、镉的迁移规律,对密胺餐具中的铅、镉进行安全风险评估研究,并提出密胺餐具中铅、镉的安全卫生标准建议值.     

食用/工业明胶的凝胶及LF-NMR弛豫特性的比较

该文研究了食品/工业明胶浓度、混合比例及蔗糖或NaCl对体系的黏度、凝冻强度及LF-NMR弛豫特性的影响。结果发现,与食用明胶相比,工业明胶的凝冻强度与黏度较低。随着明胶浓度的增加,体系的黏度、凝胶强度均相对增大;结合水弛豫时间T_(21)、自由水弛豫时间T_(22)及自由水比例S_(22)均减小,而结合水比例S_(21)增大。随着工业明胶含量的增多,混合体系的黏度与凝冻强度均线性降低,T_(21)、T_(22)及S_(21)均线性增大,S_(22)线性减小;相同蔗糖或NaCl浓度下,食用明胶体系的黏度、凝冻强度最大,混合明胶体系次之,而工业明胶体系的最小;随着蔗糖浓度的增加,体系的黏度均增大,食用、混合体系的凝冻强度增大,而工业明胶变化较小;各体系的T_(22)、S_(22)均减小,S_(21)增大,工业明胶的T_(21)增大,而食用明胶、混合明胶体系的T_(21)变化不大。随着NaCl浓度的增加,各体系的凝冻强度均相对降低,而T_(21)、T_(22)、S_(21)均相对增大,S_(22)减小。     

悬浮聚合法合成马拉硫磷分子印迹聚合物的吸附性能研究

基于分子印迹技术,采用悬浮聚合的方法,合成了马拉硫磷分子印迹聚合物。通过优化,确定最佳合成条件为:模板分子(马拉硫磷)∶功能单体(α-甲基丙烯酸)为1∶8,模板分子(马拉硫磷)∶交联剂(乙二醇二甲基丙烯酸酯)为1∶40,温度60℃,引发剂用量为1.0%。吸附性能测试结果表明,印迹聚合物对马拉硫磷的最大吸附量为4.62μg/mg,而非印迹聚合物对马拉硫磷的最大吸附量为2.21μg/mg;通过选择性实验得到印迹聚合物对灭线磷、甲拌磷、特丁硫磷、乐果、马拉硫磷、克线磷的吸附量分别为3.87、3.75、3.57、4.00、4.44、3.61μg/mg,而非印迹聚合物的吸附量分别为1.42、1.37、1.30、1.43、1.12、1.23μg/mg。     

Progresses of Magnetic Relaxation Switch Sensor in Medical Diagnosis and Food Safety Analysis

Fast and accurate detection of complex samples in either medical diagnosis or food safety analysis are of great significance for the safeguarding of human health. Magnetic relaxation switches (MRS) technique based on superparamagnetic nanoparticles (SMP) is the combination of nano-biotechnology, nuclear magnetic resonance, chemistry and immunoassay. MRS assay has the characteristics of high sensitivity and specificity, as well as nondestructive and time-saving, and can be used in turbid complex samples. In this paper, with a brief discussion about the detection theory of superparamagnetic nanosensor, the target type, structural characteristics, limit of detection, state of magnetic nanoparticles and the change of T₂ value of MRS were reviewed. The research progresses of magnetic relaxation switch sensor in medical diagnosis of different biomarkers and the analysis of food hazard factor were also summarized. Accordingly, future research targets from three aspects, e.g., preparation and modification of magnetic nanoparticles, the improvement of detection sensitivity and construction of high flux magnetic relaxation switch sensor, were put forward.