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901.
Metallo-β-lactamases (mβls) cause bacterial resistance toward a broad spectrum of β-lactam antibiotics by catalyzing the hydrolytic cleavage of the four-membered β-lactam ring, thus inactivating the drug. Minutiae of the mechanism of these enzymes are still not well understood, and reports about binding studies of the substrates to the enzymes as well as to synthetic model systems are rare. Here we report a new pyrazolate-based bioinspired dizinc complex (1) reminiscent of the active site of binuclear mβls. Since 1 does not mediate hydrolytic degradation of β-lactams, the binding of a series of common β-lactam antibiotics (benzylpenicillin, cephalotin, 6-aminopenicillanic acid, ampicillin) as well as the inhibitor sulbactam and the simplest β-lactam, 2-azetidinone, to the dizinc core of 1 could now be studied in detail by NMR and IR spectroscopy as well as mass spectrometry. X-ray crystallographic information was obtained for 1 and its complexes with 2-azetidinone (2) and sulbactam (3); the latter represents the first structurally characterized dizinc complex with a bound β-lactam drug. While 2-azetidinone was found deprotonated and bridging in the clamp of the two zinc ions in 2, in 3 and all other cases the substrates preferentially bind via their carboxylate group within the bimetallic pocket. The relevance of this binding mode for mβls and consequences for the design of functional model systems are discussed. 相似文献
902.
A new family of tetranuclear nickel cube complexes [Ni(4)L(4)(solv)(4)] (1, solv = MeOH; 2, solv = H(2)O; H(2)L = pyrazole-based tridentate {ONO} ligand) has been studied in detail, in particular by X-ray diffraction and superconducting quantum interference device (SQUID) magnetometry. Different solvates 1·H(2)O, 2·4C(3)H(6)O, 2·CH(2)Cl(2), and 2·H(2)O were obtained in crystalline form. Only small structural variations were found for the Ni-O-Ni angles of the [Ni(4)O(4)] cores of those compounds, but these slight variations have dramatic consequences for the magnetic properties. [Ni(4)L(4)(MeOH)(4)]·H(2)O (1·H(2)O) and [Ni(4)L(4)(H(2)O)(4)]·H(2)O (2·H(2)O) can be reversibly interconverted in the solid state by exposure to the respective solvent, MeOH or H(2)O, and this goes along with a switching of the spin ground state from magnetic (S(T) = 4) to diamagnetic (S(T) = 0). Likewise the (irreversible) loss of lattice solvent in [Ni(4)L(4)(H(2)O)(4)]·4C(3)H(6)O (2·4C(3)H(6)O) to give 2·2C(3)H(6)O changes the ground state from S(T) = 4 to S(T) = 0. In view of these dramatic solvatomagnetic effects for the present [Ni(4)L(4)(solv)(4)] complexes, which occur upon extrusion of lattice solvent or facile exchange of coordinated solvent molecules while keeping the robust [Ni(4)O(4)] core intact, a note of care is issued: whenever magnetic data are obtained for powdered material or for crystals that easily loose lattice solvent molecules, the magnetic properties may not necessarily reflect the situation observed in the corresponding single crystal diffraction study. Finally, a thorough analysis of the present series of complexes as well as other {Ni(4)(μ(3)-OR)(4)} cubes reported in the literature confirms that a correlation between the (Ni-O-Ni)(av) bond angle and J in [Ni(4)O(4)] cubane complexes does indeed exist. 相似文献
903.
904.
Generalized curvilinear coordinates, as, e.g., polyspherical coordinates, are in general better adapted to the resolution of the nuclear Schro?dinger equation than rectilinear ones like the normal mode coordinates. However, analytical expressions of the kinetic energy operators (KEOs) for molecular systems in polyspherical coordinates may be prohibitively complicated for large systems. In this paper we propose a method to generate a KEO numerically and bring it to a form practicable for dynamical calculations. To examine the new method we calculated vibrational spectra and eigenenergies for nitrous acid (HONO) and compare it with results obtained with an exact analytical KEO derived previously [F. Richter, P. Rosmus, F. Gatti, and H.-D. Meyer, J. Chem. Phys. 120, 6072 (2004)]. In a second example we calculated π → π* photoabsorption spectrum and eigenenergies of ethene (C(2)H(4)) and compared it with previous work [M. R. Brill, F. Gatti, D. Lauvergnat, and H.-D. Meyer, Chem. Phys. 338, 186 (2007)]. In this ethene study the dimensionality was reduced from 12 to 6 by freezing six internal coordinates. Results for both molecules show that the proposed method for obtaining an approximate KEO is reliable for dynamical calculations. The error in eigenenergies was found to be below 1 cm(-1) for most states calculated. 相似文献
905.
906.
G. V. Garkushin O. N. Ignatova G. I. Kanel L. W. Meyer S. V. Razorenov 《Mechanics of Solids》2010,45(4):624-632
We present the results of measuring the strength properties of metals and alloys with face-centered cubic lattice (copper,
aluminum), body-centered cubic structure (Armco iron, tantalum), hexagonal close-packed structure (titanium and titanium alloy
BT6) in the original coarse-grained and submicrocrystalline state under shock-wave loading. The grain dimension of the materials
under study was changed by intensive plastic deformation. The influence of the grain dimensions on the dynamic yield stress
does not always agree with the data of low-rate test even in sign, which is interpreted in the framework of general laws of
the strain rate influence on the metal and alloy flow stress. As the grain dimension decreases, there is an increase in the
compression rate in the plastic shock wave, a small increase in the fracture strength (spall strength), and an increase in
the spall fracture rate. 相似文献
907.
Ch. Loppacher M. Bammerlin M. Guggisberg E. Meyer H.-J. Güntherodt R. Lüthi R. Schlittler J.K. Gimzewski 《Applied Physics A: Materials Science & Processing》2001,72(7):S105-S108
Combined STM/AFM experiments were performed on monolayer islands of Cu-TBPP molecules on Cu(100). Pulling of single molecules on the substrate was observed and the imaging parameters were compared to STM studies. Local frequency shift vs. distance curves reveal three types of curves, which can be related to the interaction of the tip above the Cu(100) substrate, the centre of the molecule and the leg of the molecule. The frequency vs. distance curves above the legs reveal two minima, which are associated with the bending of the legs above a certain threshold value. Quantitative analysis yields force values of about 0.4 nN. 相似文献
908.
We have observed that different lamellar phases (thermotropic, lyotropic of surfactants or blockcopolymers) share the same
rheological properties = A(T)σm, m = 1.67±0.1, independently of their chemical nature, in a range of shear rates , shear stresses σ, and temperatures T, where the flow is stationary. It is argued that the key phenomenon is the appearance of screw dislocations whose glide under
an applied shear counterbalances plastically the applied vorticity, and stabilizes the layers, whose slip past each other is thus made more feasible. The theory, which
makes use in other respects of the high-temperature creep model in solids, reproduces correctly the power law behavior and
the values of A(T).
Received 18 April 2001 and Received in final form 25 October 2001 相似文献
909.
Kuang G.K. Bohm G. Graf N. Grau M. Rosel G. Meyer R. Amann M.-C. 《Photonics Technology Letters, IEEE》2001,13(4):275-277
1.79-μm InGaAs-InGaAlAs strained-layer quantum-well diode lasers have been fabricated. A characteristic temperature of 72 K has been achieved. At a temperature as high as 100°C, a continuous-wave output power of more than 6.5 mW per facet has been demonstrated with lasers using as-cleaved facets as mirrors 相似文献
910.
We investigate the steady-state rheological behaviour of the lamellar phase of a lyotropic system (CpCl, hexanol, brine)
and of a thermotropic system (8CB). Power laws characterize the behaviour of the imposed stress as a function of the measured
shear rate and similarities are observed for both systems; the same regime γ˙∼σ
m
with m≈1.7 is obtained at low shear stresses corresponding to a texture of oily streaks oriented in the direction of the flow, as
shown by microscopic observations. The “onion state” only exists in the case of dilute samples of the lyotropic lamellar phase;
the stress then varies as γ˙∼σ
m
with m≈4.8, as already observed by other groups with different systems. Rheological measurements at different temperatures allow
determination of different activation energies relating to the still badly understood processes involved in the different
rheological regimes. We propose a model which reproduces the experimental power laws and which is based on an analogy with
the theory of high-temperature creep in metals and alloys.
Received: 19 October 1999/Accepted: 1 November 1999 相似文献