酶促合成2′,3′-双脱氧双脱氢-5-氟胞嘧啶核苷的研究

从瑞士乳酸杆菌Lactobacillus helveticus(ATCC8018)中提取了N-脱氧核苷转移酶进行催化合成抗病毒药物2′,3′-双脱氧双脱氢-5-氟胞嘧啶核苷(D-D4FC)的反应.考察了反应时间、反应液的pH值、缓冲液以及反应底物浓度对反应产率的影响.     

Synthesis and Primary Research on Antitumor Activity of Three New Panaxadiol Fatty Acid Esters

For making use of Ginseng resources that exhibit an antitumor activity and for finding new anticancer drugs,three new fatty acid ester compounds: 3β-acetoxy panaxadiol ( Ⅰ ), 3β-palmitic acid aceloxy panaxadiol ( Ⅱ ), and 3β-octadecanoic acid aceloxy panaxadiol( Ⅰ , Ⅱ , and Ⅲ ) were synthesized with panaxadiol, diacetyl oxide, palmityl chloride and stearyl chloride, and their structures were determined via MS, 13C NMR, IR, TLC, and so on. The molar yields of the three compounds are 75.14%, 79. 08%, and 72. 57%, respectively. Meanwhile, the antitumor activity of the three new panaxadiol fatty acid ester derivatives and panaxadiol was compared by using the method of MTT. Tumor cell used was Vero cell line. Positive control was 5-FU, blank was an RPMI1640 culture medium, negative control was an RPMI1640 culture medium and the solvent for drugs to be tested. Compound Ⅰ has the strongest antitumor activity followed by panaxadiol; compounds Ⅱ and Ⅲ have similar and weakest antitumor activities.Furthermore, the antitumor activities of the panaxadiol fatty acid ester derivatives show positive correlation with the concentration of the test group, but show no relationship with the molecular weight of fatty acid. The methods that are used to synthesize the three compounds with high yields and strong antitumor activities are simple and show a great potential for meeting the needs of industrial manufacture of these drugs.     

Synthesis and Structure of a Dinuclear Copper（Ⅱ）- ditetrazolate Involving in situ Ligand Synthesis

The hydrothermal reaction of 1,2-dicyanobenzene with NaN3 in the presence of CuCl2, 2,2′-bipyridine and H2O affords a novel dinuclear copper(II)-ditetrazolate, [Cu(bpy)- (pdtz)]2 (Hpdtz = 5,5′-1,2-phenylene-ditetrazole, bpy = 2,2′-bipyridine). The pdtz ligand is generated in situ through Sharpless 2 3 cycloaddition reaction. Its crystal structure was deter- mined by single-crystal X-ray diffraction method. The crystal crystallizes in the monoclinic system, space group P21/n with a = 8.2096(16), b = 18.580(4), c = 11.838(2) , β = 103.12(3)o, V = 1758.5(6) 3, Z = 2, Mr = 863.83, Dc = 1.631 g/cm3, F(000) = 876 and μ = 1.272 mm-1. In this novel dinuclear structure, the pdtz ligand adopts a peculiar μ2-η1,η2 coordination mode.     

氟甲砜霉素注射液含量及其有关物质的HPLC测定

为建立测定氟甲砜霉素注射液含量的方法,采用高效液相色谱法,选用Agilent EclipseXDB-C8柱(4.6 mm×250 mm,5μm),Lab Alliance C8保护柱(4.6 mm×10 mm,5μm),流动相为(V乙腈) V(水)=35 65,流量1.0 mL.min-1,检测波长224 nm,进量样20μL,柱温为室温。结果表明,方法的线性范围为10.0～400μg.mL-1(r=0.999 6),最低检测限2.0 ng。回收率98.7%～101.2%,RSD 0.30%～1.22%(n=5)。方法简便灵敏,结果准确可靠,可用于氟甲砜霉素注射液的质量控制。     

缬沙坦类似物合成中间产物的捕获(I)(英文)

Valsartan[1], which is a very useful medicine in thetreatment of high-pressure blood, contains a tetrazolegroup. Its analogues exploration and complex actiontoward metal ions still remain very rare. As acontinuation of our in-situ [2 3] cycloaddition betw…     

缬沙坦类似物合成中间产物的捕获(Ⅱ)

In this article we mainly discuss the effect of anion of Lewis acid on the structure of the intermediate in synthesis of valsartan analogue. The crystal belongs to monoclinic system with space group P2₁/c, and a=1.099 9(3) nm, b=1.913 4(5) nm, c=0.977 8(3) nm, β=104.806(4)°, V=1.989 5(9) nm³, D_c=1.708 g·cm^-3, Z=18. CCDC: 629931.     

LiNi0.5Co0.5O2体系的结构稳定化作用和独立充放电机理

为了解释锂离子二次电池正极材料LiNi_0.5Co_0.5O₂具有的优良充放电循环性能和高比容量特征，采用基于密度泛函理论(DFT)的第一性原理计算方法对LiNi_0.5Co_0.5O₂和LiNiO₂的相关特性进行了研究。结果表明LiNi_0.5Co_0.5O₂的结构稳定性优于LiNiO₂的原因在于充放电过程中体系中Ni、Co离子交替存在的价电子构型t_2g⁶e_g⁰。依据LiNi_0.5Co_0.5O₂体系中Ni离子和Co离子相互独立的电极反应提出了适用于LiNi_xCo_1-xO₂(0≤x≤1)体系的独立充放电机理(0.2C、3.0～4.2 V vs Li⁺/Li)，并得到实验的证实。     

基于Al6Ge2O13还原制备Ge纳米粒子及其光致发光性能研究

以3-三氯锗丙酸和硝酸铝为原料，通过共沉淀法合成了Al₆Ge₂O₁₃陶瓷粉体，并利用TG-DSC、FTIR、XRD等研究了其形成过程。采用选择还原技术对Al₆Ge₂O₁₃进行还原处理，还原产物观察到发光峰位于564、611、681、730和774 nm的室温光致发光现象。比较不同温度下还原的样品，发现550 ℃保温3 h还原制备的样品发光强度最强，通过XRD、XPS和Raman光谱研究表明样品在可见和近红外光区的发光是源于平均粒径为1.98 nm且未能形成完整晶格的Ge纳米粒子团簇。     

四针状氧化锌晶须的制备及其吸波性能的研究

随着雷达探测、卫星通信、航天航空和电子对抗等高科技的发展，特别是近年来抗电磁波干扰、隐形技术、微波暗室等研究领域的兴起．对电磁波吸波材料的研究日益受到人们的重视。随着现代电子工业和信息产业的高速发展．产生电磁波的电子产品（诸如计算机、电视机、手机、微波炉及电磁炉等）的数量急剧增加，     

Synthesis, Structure and Luminescence of a Novel 2D Cadmium Coordination Polymer with a Ligand Generated in situ

The hydrothermal reaction of 1,2-dicyanobenzene with NaN3 in the presence of Cd(NO3)2 affords a novel 2D cadmium tetrazolyl-benzoate,{Cd(tzbz)(H2O)}n (H2tzbz is 2-(5-tetrazolyl)-benzoate). The tzbz ligand is generated in situ through the 2+3 Sharpless cycloaddition reaction and hydrolyzation. Its crystal structure was determined by single-crystal X-ray diffraction method. The crystal crystallizes in the orthorhombic system,space group Pbca with a=9.6659(19),b=7.6366(15),c=25.964(5) ,V=1916.5(7) 3,Z=8,Mr=318.57,Dc= 2.208 g/cm3,F(000)=1232 and μ=2.276 mm-1. The Cd(Ⅱ) atom is coordinated by four tzbz ligands and one water molecule to form a severely distorted pentangle bipyramid. While each tzbz ligand connects to four Cd(Ⅱ) atoms in a μ4-η1,η2,η1,η1,η1 coordination mode to construct a 2D architecture of the title complex. Additionally,the title complex exhibits strong fluorescence at room temperature in the solid state.