Phosphorylation of ERK-Dependent NF-κB Triggers NLRP3 Inflammasome Mediated by Vimentin in EV71-Infected Glioblastoma Cells

Enterovirus 71 (EV71) is a dominant pathogenic agent that may cause severe central nervous system (CNS) diseases among infants and young children in the Asia-pacific. The inflammasome is closely implicated in EV71-induced CNS injuries through a series of signaling pathways. However, the activation pathway of NLRP3 inflammasome involved in EV71-mediated CNS injuries remains poorly defined. In the studies, EV71 infection, ERK1/2 phosphorylation, and activation of NLRP3 are abolished in glioblastoma cells with low vimentin expression by CRISPR/Cas9-mediated knockdown. PD098059, an inhibitor of p-ERK, remarkably blocks the vimentin-mediated ERK1/2 phosphorylation in EV71-infected cells. Nuclear translocation of NF-κB p65 is dependent on p-ERK in a time-dependent manner. Moreover, NLRP3 activation and caspase-1 production are limited in EV71-infected cells upon the caffeic acid phenethyl ester (CAPE) administration, an inhibitor of NF-κB, which contributes to the inflammasome regulation. In conclusion, these results suggest that EV71-mediated NLRP3 inflammasome could be activated via the VIM-ERK-NF-κB pathway, and the treatment of the dephosphorylation of ERK and NF-κB inhibitors is beneficial to host defense in EV71-infected CNS.     

基于自适应阈值分割改进Canny算子的管道边缘检测方法研究

针对工厂中管道破损位置无法通过机器视觉准确判断的问题,提出一种基于自适应阈值分割改进Canny算子的管道边缘检测方法。该方法从滤波方式、梯度方向以及阈值分割角度对采集图像进行处理,首先采用采样-自适应中值滤波+双边滤波代替传统Canny算子中的高斯滤波,减少图像边缘信息丢失并去除图像中的噪声,然后增加梯度幅值的计算来更好地检测不同方向的边缘信息,最后为避免人工选取阈值效果不佳的情况,采用最大类间方差 (OTSU)阈值分割算 法进行阈值的自适应选取。实验表明,该方法相比于传统Canny算子的图像信噪比提升28.22%,边缘点数提升39.97%,四连通道数提升11.52%,八连通道数提升5.92%,提取特征完整且连续性较好,实现了对管道图像中破损情况的有效检测。     

透镜球差对拉盖尔-高斯涡旋光束聚焦特性的影响及改善方法

涡旋光场调控对涡旋光在激光通信、生物操控等领域的应用研究具有重要意义。为了揭示透镜球差对拉盖尔-高斯(Laguerre-Gaussian,LG)涡旋光束传输特性的影响,本文基于菲涅尔衍射理论,模拟研究了不同透镜球差系数下的LG光束聚焦场的强度、相位以及螺旋谱分布。结果表明:光学系统初级球差系数的增大恶化了LG光束聚焦场的强度分布和螺旋相位,弥散了轨道角动量(orbital angular momentum,OAM) 。由此,本文提出了一种光阑补偿方案,通过在透镜前添加大小合适的圆孔光阑,以消除透镜像差。光阑补偿后的LG光束聚焦场由星芒状空心分布恢复为空心圆环分布,OAM态保持单一稳定。本研究工作为改善透镜像差对涡旋光的传输影响提供了解决方案。     

PC机与DSP之间串行通信的实现

概要地介绍了TMS320F2812 DSP的基本性能,重点介绍了在Visual Basic 6.0下.利用MSComm控件实现上位PC机与下位机DSP之间异步串行通信的具体实现方式,并给出了一个采用RS-232串行通信标准来实现信息传输的实例.实验结果表明,串行通信简单,界面友好,改善了系统的性能,应用领域广泛.     

埋地热油管道正常运行的数值模拟研究

对高凝原油管道输送的水力热力问题进行分析研究,掌握管线运行规律,保证管线安全经济运行有着重要意义.本文建立了埋地热油管道正常运行的数学模型,采用非结构化网格和有限容积法对该问题进行了研究,计算结果与实验测量值吻合良好.     

环氧模塑料中导热通道的构造与导热性能

以低密度聚乙烯(LDPE)为原料,添加不同含量的高导热氮化硅陶瓷颗粒和短切玻璃纤维,熔融挤出不同直径的Si3N4/LDPE杆料。采用热模压法制备了环氧模塑料(EMC)。研究了杆料直径、陶瓷填充量对EMC导热性能、介电性能的影响。结果表明:在相同填充量下,杆料直径越大,样品热导率越大;5mm含玻纤杆料φ(填充量)为40%,热导率高达2.1W/(m·K)。样品的εr随杆料填充量的增大而显著减小,φ5mm含玻纤杆料填充量为40%时降至最低,为3.25(1MHz)。     

NIR TADF emitters and OLEDs: challenges,progress, and perspectives

Near-infrared (NIR) light-emitting materials show excellent potential applications in the fields of military technology, bioimaging, optical communication, organic light-emitting diodes (OLEDs), etc. Recently, thermally activated delayed fluorescence (TADF) emitters have made historic developments in the field of OLEDs. These metal-free materials are more attractive because of efficient reverse intersystem crossing processes which result in promising high efficiencies in OLEDs. However, the development of NIR TADF emitters has progressed at a relatively slower pace which could be ascribed to the difficult promotion of external quantum efficiencies. Thus, increasing attention has been paid to NIR TADF emitters. In this review, the recent progress of NIR TADF emitters has been summarized along with their molecular design strategies and photophysical properties, as well as electroluminescence performance data of their OLEDs, respectively.

This review presents the recent progress of NIR TADF emitters along with their molecular design strategies and photophysical properties, as well as the electroluminescence performance data of the emitters and their OLEDs.     

地表层的本质对于地震勘测的几种影响

一.概论用物理学的原理来计算实际问题,常常要将实际的情况先简单化或理想化,然后纔能得到有用的结果。物理探矿就是一个例子。解释地震记录时,最普通而又最简单的方法,是先假设有关的地层都是均匀、连续而又带有完全弹性的固体。     

生长MCT晶体的改进型Bridgman方法：ACRT—B

本文介绍一种经改进的采用加速坩埚旋转技术的Bridgman方法(ACRT-B)及ACRT-B用于生长MCT晶体得到的重要结果。与传统Bridgman方法生长的晶体相比,ACRT-B生长的晶体的径向组份均匀性得到很大改善;有用组份的晶片较多;晶体的结晶度好;主晶粒数目减少。ACRT-B工艺中,影响晶体质量最重要的旋转参数是最大旋转速率,而保持在最大旋转速率的时间和停止时间及反向旋转对结果的影响都很小。     

基于小波收缩的噪声图像恢复新型算法实现与验证

小波变换技术是近20年发展起来的新的信号处理技术,但对小波的研究由来已久。随着小波理论的不断完善,它以自身良好的时频特性在图像去噪领域受到越来越多的关注。图像去噪是信号处理中的一个经典问题,传统的去噪方法多采用平均或线性方法进行,但是其去噪效果不好,本文基于此目的,采用了连续两次半软阈值去噪的方法,来去除含噪图像的噪声,最后通过MATLAB软件仿真此方法的去噪效果,并与其它去噪方法进行比较,得出本文提出的方法去噪效果更优越。