Macrophage Immunomodulation Through New Polymers that Recapitulate Functional Effects of Itaconate as a Power House of Innate Immunity

Itaconate (ITA) is an emerging powerhouse of innate immunity with therapeutic potential that is limited in its ability to be administered in a soluble form. A library of polyester materials that incorporate ITA into polymer backbones resulting in materials with inherent immunoregulatory behavior is developed. Harnessing hydrolytic degradation release from polyester backbones, ITA polymers result in the mechanism specific immunoregulatory properties on macrophage polarization in vitro. In a functional assay, the polymer-released ITA inhibits bacterial growth on acetate. Translation to an in vivo model of biomaterial associated inflammation, intraperitoneal injection of ITA polymers demonstrate a rapid resolution of inflammation in comparison to a control polymer silicone, demonstrating the value of sustained biomimetic presentation of ITA.     

Scalable phase extraction methods for phase plane motion estimation

To efficiently compute the phase difference (PD) between two complex numbers, two novel approaches are described. The problem of fast PD computation is central in many applications. As a case study, the main focus is on the phase correlation technique that is used for motion estimation. Starting from the problem statement, the system requirements are dealt with showing how PD requires a remarkable amount of computational resources. Reduced complexity techniques are then proposed and specifically tailored to suit the application needs. Each solution is completely implemented both in 0.25 mum as well as 0.13 mum CMOS. The so-called LUT-ROT exhibits noteworthy figures in terms of area occupation, delay and power dissipation, saving nearly 50% in terms of area and power when compared to recent work on this subject     

Reliable eye-diagram analysis of data links via device macromodels

This paper addresses the impact of device macromodels on the accuracy of signal integrity and performance predictions for critical digital interconnecting systems. It exploits nonlinear parametric models for both single-ended and differential devices, including the effects of power supply fluctuations and receiver bit detection. The analysis demonstrates that the use of well-designed macromodels dramatically speeds up the simulation as well it preserves timing accuracy even for long bit sequences.     

Java multimedia telecollaboration

Using Java-based tools in multimedia collaborative environments accessed over the Internet can increase an application's client base. Most operating systems support Java, and its "compile once-run everywhere" architecture is easy to maintain and update. The Java-based tools presented here let users share Internet resources, including resources originally designed for single use.     

Experimental and numerical assessment of gate-lag phenomena in AlGaAs-GaAs heterostructure field-effect transistors (FETs)

Gate-lag effects are characterized in AlGaAs-GaAs heterostructure field-effect transistors (HFETs) by means of measurements and numerical device simulations. Gate lag increasingly affects device switching at increasing ungated recess extension, suggesting that responsible deep levels be located at the ungated, recess surface of the HFET. Gate lag diminishes by making the off-state gate-source voltage less negative and by increasing the drain bias. Increasing the temperature makes the turn-on transient faster at low drain bias, while slightly delaying it at high drain bias. Numerical device simulations accounting for acceptor-like traps at the ungated surface predict gate-lag phenomena in good agreement with experiments, reproducing correctly the observed bias and temperature dependences. Simulations show that surface states behave, during the turn-on transient, as hole traps capturing holes attracted at the ungated surface by the negative trapped charge.     

A New Hand-Held Microsystem Architecture for Biological Analysis

This paper presents a hand-held microsystem based on new fully integrated magnetoresistive biochips for biomolecular recognition (DNA hybridization, antibody antigen interaction, etc.). Magnetoresistive chip surfaces are chemically treated, enabling the immobilization of probe biomolecules such as DNA or antibodies. Fluid handling is also integrated in the biochip. The proposed microsystem not only integrates the biochip, which is an array of 16times16 magnetoresistive sensors, but it also provides all the electronic circuitry for addressing and reading out each transducer. The proposed architecture and circuits were specifically designed for achieving a compact, programmable and portable microsystem. The microsystem also integrates a hand-held analyzer connected through a wireless channel. A prototype of the system was already developed and detection of magnetic nanoparticles was obtained. This indicates that the system may be used for magnetic label based bioassays     

网络安全事件的关联分析方法的比较研究

随着当前攻击手段和技术的日益复杂化,一次入侵事件往往需要多个步骤才能完成,这些步骤都是彼此相关的。但是传统的入侵检测集中于检测底层的入侵或异常,所检测到的结果也仅仅是一次完整入侵的一部分,所以不能将不同的报警结合起来以发现入侵的逻辑步骤或者入侵背后的攻击策略。关联分析技术将不同分析器上产生的报警进行融合与关联分析,极大地减少了报警的数量,降低了入侵检测的误报率,并且适当的减少了入侵检测的漏报率。文中在对网络安全事件关联分析方法的系统结构进行分析后,着重介绍了当前比较流行的几种网络安全事件关联分析方法,最后对各种方法进行了比较研究。     

A tree partitioning dynamic policy for OVSF codes assignment in wideband CDMA

This paper proposes some novel techniques to accommodate users with different rate requirements in a wideband code-division multiple-access system employing orthogonal variable spreading factor codes. Two simple static code assignment strategies are first considered, and an improvement based on multicode assignment. Then the new idea of tree partitioning is introduced and used to devise a dynamic code reassignment algorithm. The behavior of these different techniques is experimentally investigated, in terms of call blocking probability and number of required reassignments. The tree partitioning method exhibits very good performances.     

Thermo-Sensitive Ba0.64Sr0.36TiO3 Thin Film Capacitors for Dielectric Type Uncooled Infrared Sensors

Ba_0.64Sr_0.36TiO₃ (BST) thin films are prepared on Pt/Ti/SiO₂/Si₃N₄/SiO₂/Si substrates by a sol-gel method. Thermo-sensitive BST thin film capacitors with a Metal-Ferroelectrics-Metal (M-F(BST)-M) structure are fabricated as the active elements of dielectric type uncooled infrared sensors. XRD are employed to analyze the crystallographic structures of the films. AFM observations reveal a smooth and dense surface of the films with an average grain size of about 35 nm. Rapid temperature annealing (RTA) process is a very efficient way to improve crystallization quality. The preferable annealing temperature is 800°C for 1 min. The butterfly shaped C-V curves of the capacitors indicate the films have a ferroelectric nature. The dielectric constant and dielectric loss of the films at 100 kHz are 450 and 0.038, respectively. At 25°C, where the thermo-sensitive capacitors work, the temperature coefficient of dielectric constant (TCD) is about 5.9 %/°C. These results indicate that the capacitors with sol-gel derived BST thin films are promising to develop dielectric type uncooled infrared sensors.     

Control system design on a power-split CVT for high-power agricultural tractors

The problem considered in this paper is the design and tuning of the control system of a power-split continuously variable transmission (CVT) used in high-power tractors. Power-split CVTs are characterized by the combination of a traditional mechanical transmission and by a continuously-variable transmission. This guarantees, at the same time, smooth variations of the transmission-ratio and high efficiency of the overall transmission system. The control architecture of an hydrostatic power-split CVT is constituted by three main parts: 1) servo-controller on the current of the valve which drives the hydraulic transmission; 2) a servo-controller on the hydraulic transmission-ratio; and 3) a synchronizer which coordinates the hydraulic and the mechanical parts of the CVT. In this work, these three controllers are fully developed, including: design, implementation, and evaluation on an experimental system.