全文获取类型
收费全文 | 890篇 |
免费 | 30篇 |
国内免费 | 10篇 |
专业分类
化学 | 527篇 |
晶体学 | 5篇 |
力学 | 28篇 |
数学 | 163篇 |
物理学 | 122篇 |
无线电 | 85篇 |
出版年
2023年 | 8篇 |
2022年 | 8篇 |
2021年 | 13篇 |
2020年 | 14篇 |
2019年 | 16篇 |
2018年 | 12篇 |
2017年 | 13篇 |
2016年 | 22篇 |
2015年 | 22篇 |
2014年 | 18篇 |
2013年 | 38篇 |
2012年 | 42篇 |
2011年 | 50篇 |
2010年 | 24篇 |
2009年 | 21篇 |
2008年 | 62篇 |
2007年 | 46篇 |
2006年 | 61篇 |
2005年 | 54篇 |
2004年 | 38篇 |
2003年 | 23篇 |
2002年 | 26篇 |
2001年 | 13篇 |
2000年 | 17篇 |
1999年 | 13篇 |
1997年 | 12篇 |
1996年 | 39篇 |
1995年 | 5篇 |
1994年 | 14篇 |
1993年 | 12篇 |
1992年 | 8篇 |
1991年 | 5篇 |
1988年 | 8篇 |
1987年 | 6篇 |
1986年 | 4篇 |
1985年 | 4篇 |
1984年 | 9篇 |
1983年 | 8篇 |
1982年 | 5篇 |
1981年 | 6篇 |
1980年 | 9篇 |
1979年 | 6篇 |
1978年 | 10篇 |
1977年 | 16篇 |
1976年 | 5篇 |
1975年 | 11篇 |
1974年 | 7篇 |
1973年 | 8篇 |
1971年 | 6篇 |
1960年 | 4篇 |
排序方式: 共有930条查询结果,搜索用时 312 毫秒
881.
Hydroxyurea is a drug recently approved to treat sickle cell diseases. Hydroxyurea benefits the patients by increasing the level of fetal hemoglobin via a nitroxide radical pathway. Here, we report an unpaired-electron-delocalization approach to tune the stability of nitroxide radicals. In this approach, the substitution by an unsaturated alkyl group containing conjugated C=C double bonds for the hydrogen on the nitrogen atom attached to the hydroxyl of hydroxyurea can significantly increase its ability to generate nitroxide radical. Furthermore, the increase can be remarkably enhanced by increasing the number of conjugated C=C double bonds. For a hydroxyurea derivative that contains two conjugated C=C double bonds, the reaction rate to generate its radical is 118 times faster than that of hydroxyurea, and for a hydroxyurea derivative containing 20 conjugated C=C double bonds, the reaction rate to form its radical is 238 times faster than that of hydroxyurea. For this reason, hydroxyurea derivatives with conjugated C=C double bonds may constitute new potential drugs for the treatment of sickle-cell diseases. 相似文献
882.
Vlaisavljevich E Janka LP Ong KG Rajachar RM 《IEEE transactions on bio-medical engineering》2011,58(3):698-704
Interfacial fibrosis is known to dramatically decrease the lifespan, stability, and function of biomedical implants and bone-anchored prosthetics. Bioactive coatings aimed at mitigating fibrous adhesions are one of the approaches to alleviate the problem. In this paper, we are developing a bioactive coating based upon a magnetoelastic (ME) material that vibrates in response to an ac magnetic field. In order to establish these coatings for this purpose, the ME material was first rendered bioactive through the sequential addition of polyurethane and chitosan thin films. Indirect live/dead assays were performed showing increased cell viability for polyurethane and chitosan-coated sensors compared to the uncoated controls. Direct adhesion experiments were performed to test the response of fibroblasts cultured on static and vibrated ME materials. Results showed cells adherent to static but not vibrated coatings. Detached cells showed no viability loss compared to controls. The finding that submicrometer ME vibrations can prevent cell adhesion in vitro without inducing cell death suggests the potential of these coatings to effectively control interfacial fibrosis. Future work will address the effect of vibrations on cell morphology and local gene expression in vitro, as well as fibrous tissue formation in vivo. 相似文献
883.
Semiclassical Gaussian approximations to the Boltzmann operator have become an important tool for the investigation of thermodynamic properties of clusters of atoms at low temperatures. Usually, numerically expensive thawed Gaussian variants are applied. In this article, we introduce a numerically much cheaper frozen Gaussian approximation to the imaginary time propagator with a width matrix especially suited for the dynamics of clusters. The quality of the results is comparable to that of thawed Gaussian methods based on the single-particle ansatz. We apply the method to the argon trimer and investigate the dissociation process of the cluster. The results clearly show a classical-like transition from a bounded moiety to three free particles at a temperature T ≈ 20 K, whereas previous studies of the system were not able to resolve this transition. Quantum effects, i.e., differences with the purely classical case manifest themselves in the low-temperature behavior of the mean energy and specific heat as well as in a slight shift of the transition temperature. We also discuss the influence of an artificial confinement of the atoms usually introduced to converge numerical computations. The results show that restrictive confinements often implemented in studies of clusters can influence the thermodynamic properties drastically. This finding may have implications on other studies of atomic clusters. 相似文献
884.
The frozen Gaussian approximation to the quantum propagator may be a viable method for obtaining "on the fly" quantum dynamical information on systems with many degrees of freedom. However, it has two severe limitations, it rapidly loses normalization and one needs to know the Gaussian averaged potential, hence it is not a purely local theory in the force field. These limitations are in principle remedied by using the Herman-Kluk (HK) form for the semiclassical propagator. The HK propagator approximately conserves unitarity for relatively long times and depends only locally on the bare potential and its second derivatives. However, the HK propagator involves a much more expensive computation due to the need for evaluating the monodromy matrix elements. In this paper, we (a) derive a new formula for the normalization integral based on a prefactor free HK propagator which is amenable to "on the fly" computations; (b) show that a frozen Gaussian version of the normalization integral is not readily computable "on the fly"; (c) provide a new insight into how the HK prefactor leads to approximate unitarity; and (d) how one may construct a prefactor free approximation which combines the advantages of the frozen Gaussian and the HK propagators. The theoretical developments are backed by numerical examples on a Morse oscillator and a quartic double well potential. 相似文献
885.
886.
A new chromatographic stationary phase obtained by coating a reversed phase amide column with phosphatidylcholine based liposomes solution to yield a phospholipid modified column (PLM). The modification is achieved by the dynamic coating method which recycles the coating solution through the column in a closed loop for a period of 24 h. The chromatographic properties of the new column have changed significantly as compared to the original amide column due to the phospholipid coating. A good correlation was observed between n-octanol/water logP values and the logarithm of the retention factor obtained on the PLM column for a large number of solutes. In addition the PLM column was characterized using the linear solvation energy relationship (LSER). The values of the LSER system constants for the PLM column were calculated and were found to be very close to those of the n-octanol/water extraction system thus suggesting that the PLM column can be used for the estimation of n-octanol/water partition coefficient and serve as a possible alternative to the shake-flask method for lipophilicity determination. In addition, the results suggest that the PLM column can provide an alternative to other phospholipid-based column such as the IAM and the DPC columns. 相似文献
887.
Stavitski E Pidko EA Couck S Remy T Hensen EJ Weckhuysen BM Denayer J Gascon J Kapteijn F 《Langmuir : the ACS journal of surfaces and colloids》2011,27(7):3970-3976
Some Metal Organic Frameworks (MOFs) show excellent performance in extracting carbon dioxide from different gas mixtures. The origin of their enhanced separation ability is not clear yet. Herein, we present a combined experimental and theoretical study of the amino-functionalized MIL-53(Al) to elucidate the mechanism behind its unusual high efficiency in CO(2) capture. Spectroscopic and DFT studies point out only an indirect role of amine moieties. In contrast to other amino-functionalized CO(2) sorbents, no chemical bond between CO(2) and the NH(2) groups of the structure is formed. We demonstrate that the functionalization modulates the "breathing" behavior of the material, that is, the flexibility of the framework and its capacity to alter the structure upon the introduction of specific adsorbates. The absence of strong chemical interactions with CO(2) is of high importance for the overall performance of the adsorbent, since full regeneration can be achieved within minutes under very mild conditions, demonstrating the high potential of this type of adsorbents for PSA like systems. 相似文献
888.
We apply the modal coherence theory to evaluate the spatial mode structure of a 2×2 phase-coupled array of vertical cavity surface emitting lasers (VCSELs). The eigenmode structure is extracted for different pump currents by measuring the degree of spatial coherence of all VCSEL pairs in the array. The results reveal the impact of optical disorder and spatial hole burning on the modal discrimination. The approach is useful more generally for the evaluation of spatial mode content of other laser array. 相似文献
889.
Distribution and behavior of some radionuclides associated with the Trinity nuclear test 总被引:1,自引:0,他引:1
Jeremy J. Bellucci Christine Wallace Elizabeth C. Koeman Antonio Simonetti Peter C. Burns Jeremy Kieser Eli Port Terri Walczak 《Journal of Radioanalytical and Nuclear Chemistry》2013,295(3):2049-2057
The activities of 133Ba, 137Cs, 152Eu, 154Eu, 155Eu, 239Pu, and 241Am were determined by gamma spectroscopy on the largest sample set (n = 49) of bulk trinitite to date. The range in activity for all isotopes is large. For example, the activity of 241Am (normalized to the time of detonation) ranges between 1 and 42 Bq/g. Comparison of activities for isotopes derived from the device, 241Am versus 137Cs, 155Eu, and 239Pu, indicate positive trends. Correlations were not observed between the activities of the soil-derived activation products 152Eu and 154Eu and the radioisotopes from the device. The calculated ratio of fission products (155Eu/137Cs) is 0.012 ± .006 (1σ, n = 3), which is lower than predicted for the thermal neutron-induced fission of 239Pu (~0.03). This discrepancy may be attributed to the spontaneous fission of the natural U tamper resulting in mixing between fission products from 239Pu and 235U. The spatial distribution of the trinitite samples relative to ground zero has been modeled based on the activity of 152Eu. The calculated distances do not correlate with any of the activities for the radioisotopes investigated here, and suggest a relatively homogeneous distribution. However, trinitite samples with the highest activities for 137Cs, 239Pu, and 241Am yield the shortest calculated distances of 50–60 m away from ground zero. 相似文献
890.
Shyuan Yang Brian R. Tull Nadia K. Pervez Limin Huang Eli S. Leland Daniel A. Steigart Stephen O'Brien Ioannis Kymissis 《Journal of Polymer Science.Polymer Physics》2013,51(1):35-38
Nanoparticle polymer composite capacitors have been examined for some time as a route to high performance, printable capacitors. One approach to creating these composites is to use a particle film together with vapor deposited polymers, which can yield high performance, but also forms a structurally asymmetric device. The performance of a nanoparticle (Ba, Sr)TiO3 (BST)/parylene‐C composite capacitor is compared to that of a nanoparticle BST capacitor without the polymer layer under both directions of bias. The composite device shows a five orders of magnitude improvement in the leakage current under positive bias of the bottom electrode relative to the pure‐particle device, and four orders of magnitude improvement when the top electrode is positively biased. The voltage tolerance of the device is also improved and asymmetric (44 V vs. 28 V in bottom and top positive bias, respectively). This study demonstrates the advantage of this class of composite device construction, but also shows that proper application of the device bias in this type of asymmetrical system can yield an additional benefit. © 2012 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2013 相似文献