Synthesis and Characterization of a Fluorescent Water-Borne Polyurethane Based on a Novel Naphthalimide Dye

A waterborne-polyurethane (WPU) dye, based on the fluorescent dye 4-diamino propane-N-allyl-1,8- naphthalimide (WPU-DAN), was synthesized by attaching 4-diamino propane-N-allyl-1,8- naphthalimide (DAN) onto both ends of the polyurethane (PU) chains according to a prepolymer?ionomer process. The synthetic process was confirmed by Fourier transform infrared spectroscopy (FTIR) and UV-visible absorption. The glass transition temperature, molecular weight and average particle sizes were measured. The glass transition temperatures of WPU and WPU-DAN were 46.6 and 49.8°C, respectively. In addition, the particle size distributions of WPU-DAN and WPU were 140 and 134 nm, respectively. The thermal behaviour of WPU-DAN showed improvement compared to WPU. The fluorescence intensity of WPU-DAN was enhanced more than DAN due to the naphthalimide groups attached to the chains, and the fluorescence intensity of WPU-DAN and DAN were increased by increasing temperature. Moreover, the fluorescence intensity of WPU-DAN emulsion was stable during 30 days and no loss of fluorescence intensity occurred for these days.     

Nonlinear integral resonant controller for vibration reduction in nonlinear systems

A new nonlinear integral resonant controller (NIRC) is introduced in this paper to suppress vibration in nonlinear oscillatory smart structures. The NIRC consists of a first-order resonant integrator that provides additional damping in a closed-loop system response to reduce high-amplitude nonlinear vibration around the fundamental reso-nance frequency. The method of multiple scales is used to obtain an approximate solution for the closed-loop system. Then closed-loop system stability is investigated using the resulting modulation equation. Finally, the effects of different control system parameters are illustrated and an approximate solution response is verified via numerical simulation results. The advantages and disadvantages of the proposed controller are presented and extensively discussed in the results. The controlled system via the NIRC shows no high-amplitude peaks in the neighboring frequencies of the resonant mode, unlike conventional second-order compensation methods. This makes the NIRC controlled system robust to excitation frequency variations.     

CMOS silicon avalanche photodiodes for NIR light detection: a survey

This paper surveys recent research on CMOS silicon avalanche photodiodes (SiAPD) and presents the design of a SiAPD based photoreceiver dedicated to near-infrared spectroscopy (NIRS) application. Near-infrared spectroscopy provides an inexpensive, non-invasive, and portable means to image brain function, and is one of the most efficient diagnostic techniques of different neurological diseases. In NIRS system, brain tissue is penetrated by near-infrared (NIR) radiation and the reflected signal is captured by a photodiode. Since the reflected NIR signal has very low amplitude, SiAPD is a better choice than regular photodiode for NIR signal detection due to SiAPD`s ability to amplify the photo generated signal by avalanche multiplication. Design requirements of using CMOS SiAPDs for NIR light detection are discussed, and the challenges of fabricating SiAPDs using standard CMOS process are addressed. Performances of state-of-the-art CMOS SiAPDs with different device structures are summarized and compared. The efficacy of the proposed SiAPD based photoreceiver is confirmed by post layout simulation. Finally, the SiAPD and its associated circuits has been implemented in one chip using 0.35 μm standard CMOS technology for an integrated NIRS system.     

Using anisotropic diffusion equations in pixon domain for image de-noising

Image enhancement is an essential phase in many image processing algorithms. In any image de-noising algorithm, it is a major concern to keep the interesting structures of the image. Such interesting structures in an image often correspond to the discontinuities in the image (edges). In this paper, we propose a new algorithm for image de-noising using anisotropic diffusion equations in pixon domain. In this approach, diffusion equations are applied on the pixonal model of the image. The algorithm has been examined on a variety of standard images and the performance has been compared with algorithms known from the literature. The experimental results show that in comparison with the other existing methods, the proposed algorithm has a better performance in de-noising and preserving image edges.     

High-throughput biophysical measurement of human red blood cells

This paper reports a microfluidic system for biophysical characterization of red blood cells (RBCs) at a speed of 100-150 cells s(-1). Electrical impedance measurement is made when single RBCs flow through a constriction channel that is marginally smaller than RBCs' diameters. The multiple parameters quantified as mechanical and electrical signatures of each RBC include transit time, impedance amplitude ratio, and impedance phase increase. Histograms, compiled from 84,073 adult RBCs (from 5 adult blood samples) and 82,253 neonatal RBCs (from 5 newborn blood samples), reveal different biophysical properties across samples and between the adult and neonatal RBC populations. In comparison with previously reported microfluidic devices for single RBC biophysical measurement, this system has a higher throughput, higher signal to noise ratio, and the capability of performing multi-parameter measurements.     

Phorbol Esters from Jatropha Meal Triggered Apoptosis, Activated PKC-δ, Caspase-3 Proteins and Down-Regulated the Proto-Oncogenes in MCF-7 and HeLa Cancer Cell Lines

Jatropha meal produced from the kernel of Jatropha curcas Linn. grown in Malaysia contains phorbol esters (PEs). The potential benefits of PEs present in the meal as anticancer agent are still not well understood. Hence, this study was conducted to evaluate the cytotoxic effects and mode of actions of PEs isolated from Jatropha meal against breast (MCF-7) and cervical (HeLa) cancer cell lines. Isolated PEs inhibited cells proliferation in a dose-dependent manner of both MCF-7 and HeLa cell lines with the IC₅₀ of 128.6 ± 2.51 and 133.0 ± 1.96 μg PMA equivalents/mL respectively, while the values for the phorbol 12-myristate 13-acetate (PMA) as positive control were 114.7 ± 1.73 and 119.6 ± 3.73 μg/mL, respectively. Microscopic examination showed significant morphological changes that resemble apoptosis in both cell lines when treated with PEs and PMA at IC₅₀ concentration after 24 h. Flow cytometry analysis and DNA fragmentation results confirmed the apoptosis induction of PEs and PMA in both cell lines. The PEs isolated from Jatropha meal activated the PKC-δ and down-regulated the proto-oncogenes (c-Myc, c-Fos and c-Jun). These changes probably led to the activation of Caspase-3 protein and apoptosis cell death occurred in MCF-7 and HeLa cell lines upon 24 h treatment with PEs and PMA. Phorbol esters of Jatropha meal were found to be promising as an alternative to replace the chemotherapeutic drugs for cancer therapy.     

Phenolics and flavonoids compounds, phenylanine ammonia lyase and antioxidant activity responses to elevated CO₂ in Labisia pumila (Myrisinaceae)

A split plot 3 × 3 experiment was designed to examine the impact of three concentrations of CO? (400, 800 and 1,200 μmol·mol?1) on the phenolic and flavonoid compound profiles, phenylalanine ammonia lyase (PAL) and antioxidant activity in three varieties of Labisia pumila Benth. (var. alata, pumila and lanceolata) after 15 weeks of exposure. HPLC analysis revealed a strong influence of increased CO? concentration on the modification of phenolic and flavonoid profiles, whose intensity depended on the interaction between CO? levels and L. pumila varieties. Gallic acid and quercetin were the most abundant phenolics and flavonoids commonly present in all the varieties. With elevated CO? (1,200 μmol·mol?1) exposure, gallic acid increased tremendously, especially in var. alata and pumila (101-111%), whilst a large quercetin increase was noted in var. lanceolata (260%), followed closely by alata (201%). Kaempferol, although detected under ambient CO? conditions, was undetected in all varieties after exposure. Instead, caffeic acid was enhanced tremendously in var. alata (338~1,100%) and pumila (298~433%). Meanwhile, pyragallol and rutin were only seen in var. alata (810 μg·g?1 DW) and pumila (25 μg·g?1 DW), respectively, under ambient conditions; but the former compound went undetected in all varieties while rutin continued to increase by 262% after CO? enrichment. Interestingly, naringenin that was present in all varieties under ambient conditions went undetected under enrichment, except for var. pumila where it was enhanced by 1,100%. PAL activity, DPPH and FRAP also increased with increasing CO? levels implying the possible improvement of health-promoting quality of Malaysian L. pumila under high CO? enrichment conditions.     

Numerical investigation of turbulent free jet flows issuing from rectangular nozzles: the influence of small aspect ratio

In this research, the fluid and thermal characteristics of a rectangular turbulent jet flow is studied numerically. The results of three-dimensional jet issued from a rectangular nozzle are presented. A numerical method employing control volume approach with collocated grid arrangement was employed. Velocity and pressure fields are coupled with SIMPLEC algorithm. The turbulent stresses are approximated using k–e{\varepsilon} model with two different inlet conditions. The velocity and temperature fields are presented and the rates of their decay at the jet centerline are noted. The velocity vectors of the main flow and the secondary flow are illustrated. Also, effect of aspect ratio on mixing in rectangular cross-section jets is considered. The aspect ratios that were considered for this work were 1:1 to 1:4. The results showed that the jet entrains more with smaller AR. Special attention has been drawn to the influence of the Reynolds number (based on hydraulic diameter) as well as the inflow conditions on the evolution of the rectangular jet. An influence on the jet evolution is found for smaller Re, but the jet is close to a converged state for higher Reynolds numbers. The inflow conditions have considerable influence on the jet characteristics.     

Exogenous Application of Green Titanium Dioxide Nanoparticles (TiO2 NPs) to Improve the Germination,Physiochemical, and Yield Parameters of Wheat Plants under Salinity Stress

Agriculture is the backbone of every developing country. Among various crops, wheat (Triticum aestivum L.) belongs to the family Poaceae and is the most important staple food crop of various countries. Different biotic (viruses, bacteria and fungi) and abiotic stresses (water logging, drought and salinity) adversely affect the qualitative and quantitative attributes of wheat. Among these stresses, salinity stress is a very important limiting factor affecting the morphological, physiological, biochemical attributes and grain yield of wheat. This research work was carried out to evaluate the influence of phytosynthesized TiO₂ NPs on the germination, physiochemical, and yield attributes of wheat varieties in response to salinity. TiO₂ NPs were synthesized using TiO₂ salt and a Buddleja asiatica plant extract as a reducing and capping agent. Various concentrations of TiO₂ nanoparticles (20, 40, 60 and 80 mg/L) and salt solutions (NaCl) (100 and 150 mM) were used. A total of 20 mg/L and 40 mg/L improve germination attributes, osmotic and water potential, carotenoid, total phenolic, and flavonoid content, soluble sugar and proteins, proline and amino acid content, superoxide dismutase activity, and reduce malondialdhehyde (MDA) content at both levels of salinity. These two concentrations also improved the yield attributes of wheat varieties at both salinity levels. The best results were observed at 40 mg/L of TiO₂ NPs at both salinity levels. However, the highest concentrations (60 and 80 mg/L) of TiO₂ NPs showed negative effects on germination, physiochemical and yield characteristics and causes stress in both wheat varieties under control irrigation conditions and salinity stress. Therefore, in conclusion, the findings of this research are that the foliar application of TiO₂ NPs can help to improve tolerance against salinity stress in plants.     

Modified lattice Boltzmann solution for non-isothermal rarefied gas flow through microchannel utilizing BSR and second-order implicit schemes

Journal of Thermal Analysis and Calorimetry - Thermal microscale gas flow was simulated into a coplanar microchannel was simulated at a broad range of Knudsen numbers. Attempts were made to improve...