Anomalous charge transport in multiple interconnected polyaniline nanofibers

We report the unusual charge transport phenomena in polyaniline nanofiber networks and its dependencies on temperature, applied magnetic and electric field, and on the type of fiber morphology. The conductivity of nanofiber networks follows quasi 1-D variable range hopping (VRH) and demonstrates a peak at ～240 K in samples with high density of interfiber intersections. This anomalous peak of conductivity is attributed to change in the interfiber contact resistance with temperature. In all polyaniline nanofiber networks, positive and negative magnetoresistances (MRs) are observed and accounted for by shrinkage of localized electron wavefunctions and suppression of quantum interference among possible tunneling paths by magnetic field. We found that the magnitude of both positive and negative MR gets smaller with decreasing density of interfiber intersections and can be explained by decreasing of hopping barriers as well as decreasing of number of current pathways within VRH network. We also detected that the magnitude of MR in polyaniline nanofiber networks is affected by the applied electric field which we propose is due to field-induced suppression of the hopping activation energies.     

On the Structure of Graphs with Low Obstacle Number

The obstacle number of a graph G is the smallest number of polygonal obstacles in the plane with the property that the vertices of G can be represented by distinct points such that two of them see each other if and only if the corresponding vertices are joined by an edge. We list three small graphs that require more than one obstacle. Using extremal graph theoretic tools developed by Pr?mel, Steger, Bollobás, Thomason, and others, we deduce that for any fixed integer h, the total number of graphs on n vertices with obstacle number at most h is at most 2^o(n2){2^{o(n^2)}}. This implies that there are bipartite graphs with arbitrarily large obstacle number, which answers a question of Alpert et al. (Discret Comput Geom doi:, 2009).     

Biodegradable Implantable Sensors: Materials Design,Fabrication, and Applications

The ability to monitor diseases, therapies, and their effects on the body is a critical component of modern care and personalized medicine. Real time monitoring can be achieved by analyzing body fluids or by applying sensors on, or alternatively, inside the body. Implantable sensors, however, must be removed. Second removal procedures lead to further tissue damage, which can be a problem in tissues such as those of the central nervous system. The use of biodegradable sensors alleviates these problems since they do not require removal procedures. Recent advances in material science made it possible for all sensor components to be biodegradable. Small size and power of implants, and the limited selection of materials are the main constraints determining the capabilities of the biodegradable device. Thus, the design will be always a challenge exploring a trade-off among these parameters. Despite of the encouraging results illustrating that biodegradable sensors can be as accurate and reliable as commercially available nondegradable ones, biodegradable implantable sensors are still in their infancy. Significant advances made in this area are critically reviewed in this paper, and future prospects are highlighted.     

Solvent-free microwave extraction and hydrodistillation of essential oils from endemic Origanum husnucanbaseri H. Duman, Aytac & A. Duran: comparison of antibacterial activity and contents

The essential oils (EOs) obtained by solvent-free microwave extraction (SFME) and hydrodistillation (HD) from endemic Origanum husnucanbaseri H. Duman, Aytac & A. Duran were investigated using the gas chromatography-mass spectrometry system. The main constituents of both oils obtained from SFME and HD from O. husnucanbaseri are borneol (15.2-12.8%), α-terpineol (12.3-10.8%) and trans-sabinene hydrate (11.8-9.92%). The EO obtained from SFME contained substantially higher amounts of oxygenated compounds and lower amounts of monoterpenes than that from HD. The antibacterial activities of the EOs from SFME and HD were evaluated by the disc diffusion method against six bacterial strains. The EO extracted by SFME was more effective than the EO extracted by HD against the tested bacteria, except for Klebsiella pneumoniae American type culture collection (ATCC) 13883. Streptococcus pyogenes ATCC 19615 and Staphylococcus aureus ATCC 25923 in particular were more sensitive against the EO extracted by SFME.     

Quantum mechanical calculations of tryptophan and comparison with conformations in native proteins

We report a detailed analysis of the potential energy surface of N-acetyl-l-tryptophan-N-methylamide, (NATMA) both in the gas phase and in solution. The minima are identified using the density-functional-theory (DFT) with the 6-31g(d) basis set. The full potential energy surface in terms of torsional angles is spanned starting from various initial configurations. We were able to locate 77 distinct L-minima. The calculated energy maps correspond to the intrinsic conformational propensities of the individual NATMA molecule. We show that these conformations are essentially similar to the conformations of tryptophan in native proteins. For this reason, we compare the results of DFT calculations in the gas and solution phases with native state conformations of tryptophan obtained from a protein library. In native proteins, tryptophan conformations have strong preferences for the beta sheet, right-handed helix, tight turn, and bridge structures. The conformations calculated by DFT, the solution-phase results in particular, for the single tryptophan residue are in agreement with native state values obtained from the Protein Data Bank.     

Cationic oligonucleotide-peptide conjugates with aggregating properties enter efficiently into cells while maintaining hybridization properties and enzymatic recognition

Oligonucleotide delivery is a crucial issue for therapeutical purposes and is often addressed by conjugation to short cationic peptides although with controversial results. To further examine this mechanism, a 15-mer anionic oligonucleotide was conjugated to a cationic peptide in order to obtain a diblock compound with an overall positive charge with aggregation properties. These microaggregates were efficiently internalized in cells via the expeditious pathway used by commercial gene delivery systems. Moreover, stability of the duplex formed with the complementary sequence increased without inhibiting oligonucleotide enzyme recognition as shown by the properties of the conjugate to prime chain elongation by Taq DNA polymerase in a linear amplification/sequencing process.