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131.
132.
A. Rahman Dick Van Der Helm Melvin D. Herd M. M. Hashem K. Darrell Berlin 《Journal of heterocyclic chemistry》1980,17(7):1549-1552
Screening data for the carcinostatic activity of 2-allylamino-4,5-dihydro-7,8-dimethoxynaphtho[1,2-d]-thiazole is reported. Significant T/C values (survival ratio) were found when the title compound was used to treat colon 38 tumors in the testing program of the National Cancer Institute. A single crystal X-ray diffraction analysis was made of the compound and revealed an essentially planar arrangement of the aromatic and heterocyclic rings. The compound crystallizes in the space group P21/c with cell dimensions a = 7.9177(27) ǎ, b = 14.999(10) ǎ, c = 13.237(4) ǎ, β = 107.56(2)°, Z = 4 at -135 ± 2°C. The intensity data were collected at low temperature using CuKα radiation. The structure was determined by direct methods and refined to an R-factor of 0.036 for the 2606 observed data. The internuclear distances were calculated between the two oxygen atoms and N(1) for comparison with such “triangulation” data of other systems with known inhibitory characteristics of cell growth. 相似文献
133.
K. Darrell Berlin S. Rengaraju Peter E. Clark 《Journal of heterocyclic chemistry》1970,7(5):1095-1099
Several new phosphorylated aziridines of related structure were prepared. P.m.r. analysis via decoupling experiments provided cis H-H, trans H-H, gem H-H and PNCH coupling values. Similar to simple aziridines, the cis H-H coupling is larger than trans H-H coupling (on vicinal ring carbons) which in turn is larger than gem H-H coupling. In one example operating at 100 MHz and 0° it was possible to detect the presence of two invertomers. 相似文献
134.
Jerrold M. Liesch Charles C. Sweeley Glenn D. Staffeld Matt S. Anderson Darrell J. Weber Robert P. Scheffer 《Tetrahedron》1982,38(1):45-48
, which is pathogenic to maize, produces a metabolite, HC-toxin (), with selective toxicity to susceptible host genotypes. Resistant genotypes and non host plants are tolerant. The structure of (C21H32N4O6) was determined as cyclo [(2-amino-9,10-epoxy-8-oxodecanoyl)-alanyl-alanyl-prolyl] based upon spectral evidence. 相似文献
135.
Melaiye A Sun Z Hindi K Milsted A Ely D Reneker DH Tessier CA Youngs WJ 《Journal of the American Chemical Society》2005,127(7):2285-2291
Silver(I)-imidazole cyclophane gem-diol complex, 3 [Ag2C36 N10(O)4](2+)2(x)-, where x = OH- or CO3(2-), was synthesized and well characterized. The minimum inhibition concentration tests showed that the aqueous form of 3 is 2 times less effective as an antibiotic than 0.5% AgNO3, with about the same amount of silver. The antimicrobial activity of 3 was enhanced when encapsulated into Tecophilic polymer by electrospinning to obtain mats made of nano-fibers. The fiber mats released nanosilver particles, which in turn sustained the antimicrobial activity of the mats over a long period of time. The rate of bactericidal activity of 3 was greatly improved by encapsulation, and the amount of silver used was much reduced. The amount of silver contained in the fiber mat of 3, with 75% of 3 and 25% Tecophilic, was 8 times less than that in 0.5% AgNO3 and 5 times lower than that in silver sulfadiazine cream 1%. The fiber mat was found to kill S. aureus at the same rate as 0.5% AgNO3, with zero colonies on an agar plate, and about 6 times faster than silver sulfadiazine cream. The silver mats were found effective against E. coli, P. aeruginosa, S. aureus, C. albicans, A. niger, and S. cerevisiae. Transmission electron microscopy and scanning electron microscopy were used to characterize the fiber mats. The acute toxicity of the ligand (imidazolium cyclophane gem-diol dichloride) was assessed by intravenous administration to rats, with an LD 50 of 100 mg/kg of rat. 相似文献
136.
Cynthia J. Bruckner-Lea Toyoko TsukudaBrian Dockendorff James C. FollansbeeMark T. Kingsley Cathy OcampoJennie R. Stults Darrell P. Chandler 《Analytica chimica acta》2002,469(1):129-140
There is an increasing need for field-portable systems for the detection and characterization of microorganisms in the environment. Nucleic acids analysis is frequently the method of choice for discriminating between bacteria in complex systems, but standard protocols are difficult to automate and current microfluidic devices are not configured specifically for environmental sample analysis. In this report, we describe the development of an integrated DNA purification and polymerase chain reaction (PCR) amplification system and demonstrate its use for the automated purification and amplification of Geobacter chapellei DNA (genomic DNA or plasmid targets) from sediments. The system includes renewable separation columns for the automated capture and release of microparticle purification matrices, and can be easily reprogrammed for new separation chemistries and sample types. The DNA extraction efficiency for the automated system ranged from 3 to 25%, depending on the length and concentration of the DNA target. The system was more efficient than batch capture methods for the recovery of dilute genomic DNA even though the reagent volumes were smaller than required for the batch procedure. The automated DNA concentration and purification module was coupled to a flow-through, Peltier-controlled DNA amplification chamber, and used to successfully purify and amplify genomic and plasmid DNA from sediment extracts. Cleaning protocols were also developed to allow reuse of the integrated sample preparation system, including the flow-through PCR tube. 相似文献
137.
Keitaro Senga Joze Kobe Roland K. Robins Darrell E. O'Brien 《Journal of heterocyclic chemistry》1975,12(5):893-898
The synthesis of a new series of alkylxanthine analogs containing a bridgehead nitrogen atom is reported. 1,3-Dialkylpyrazolo[1,5-a]-1,3,5-triazine-2,4-diones, were prepared by the treatment of 3-methylpyrazolo[1,5-a]-1,3,5-triazine-2,4-dione (3) with the corresponding alkyl iodide. Similarly, the reaction of 3-methyl-7-phenylpyrazolo[1,5-a]-1,3,5-dialkyl-7-phenylpyrazolo[1,5-a]-1,3,5-triazine-2,4-diones. The starting materials, 3 and 17 , were prepared via the reaction of an appropriate 3-aminopyrazole with ethoxycarbonyl isothiocyanate. Several 8-bromo derivatives were prepared by direct bromination of the 1,3-dialkylpyrazolo[1,5-a]-1,3,5-triazine-2,4-diones. 相似文献
138.
P.Darrell Ownby 《Journal of solid state chemistry》2004,177(2):466-470
The separation of the boron isotopes using boron trifluoride·organic-donor, Lewis acid·base adducts is an essential first step in preparing 10B enriched and depleted crystalline solids so vital to nuclear studies and reactor applications such as enriched MgB2, boron carbide, ZrB2, HfB2, aluminum boron alloys, and depleted silicon circuits for radiation hardening and neutron diffraction crystal structure studies. The appearance of this new adduct with such superior properties demands attention in the continuing search for more effective and efficient means of separation. An evaluation of the boron trifluoride nitromethane adduct, its thermodynamic and physical properties related to large-scale isotopic separation is presented. Its remarkably high separation factor was confirmed to be higher than the expected theoretical value. However, the reportedly high acid/donor ratio was proven to be an order of magnitude lower. On-going research is determining the crystal structure of deuterated and 11B enriched 11BF3·CD3NO2 by X-ray and neutron diffraction. 相似文献
139.
The influence of humic acid on the adhesion of Escherichia coli to silica particles or glass surfaces was investigated. After adsorbing various amounts of humic acid to the particles or surfaces, bacteria were added to the sample and allowed to adhere. For the silica particles the number of bacteria-particle couplets formed were counted from video microscopy images. For the glass surfaces, a differential electrophoresis force was applied, and the force required to detach the bacteria was quantified. These experiments showed a slight increase in the number of couplets formed in the presence of humic acid, and also showed a slight increase in the force required for detachment of the bacteria. Although an increase in adhesion number and strength was measured, the magnitude of the increase was small, indicating that humic acid plays a small role in bacterial adhesion to silica or glass surfaces. 相似文献
140.
John G. Morgan K. Darrell Berlin Norman N. Durham Robert W. Chesnut 《Journal of heterocyclic chemistry》1971,8(1):61-63
This study reports the complete synthesis and characterization of the 15, 16-diazaequilenin derivative 10,11-dihydro-3H-naphth[1,2-g]indazol-7-ol ( 2b ) as well as the methyl ether 2a of the above compound and the novel “model” compound 4,5-dihydro-1H-benz[g]indazol-7-ol ( 3b ). Indazoles 2a and 3a have demonstrated in vitro activity against a variety of microorganisms. 相似文献