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161.
Chalcones may be cyclised to the corresponding flavanones by stirring with KF-celite suspended in methanol at reflux. This method gives consistently higher conversion than other reported procedures and its utility is illustrated by the synthesis of the linear prenylated flavanone bavachinin. 相似文献
162.
Inside Cover: Stapled Peptides with γ‐Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction (Angew. Chem. Int. Ed. 13/2016) 下载免费PDF全文
163.
Structure‐guided RP‐HPLC chromatography of diastereomeric α‐helical peptide analogs substituted with single amino acid stereoisomers 下载免费PDF全文
YiBing Huang Ling Pan LianJing Zhao Colin T. Mant Robert S. Hodges Yuxin Chen 《Biomedical chromatography : BMC》2014,28(4):511-517
An α‐helical model peptide (Ac‐EAEKAAKE‐X‐EKAAKEAEK‐amide) was used as a template to examine the efficacy of conventional reversed‐phase high‐performance liquid chromatography (RP‐HPLC) in separating peptide analogs with single substitutions (at position X) of diasteromeric amino acids Ile, allo‐Ile, d ‐Ile and d ‐allo‐Ile. We compared differences in peptide retention behavior on a C8 column and a C18 column at different temperatures. We demonstrated how subtle differences in peptide secondary structure affected by the different substitutions of amino acids with identical overall hydrophobicity enabled effective resolution of these peptide analogs. We also demonstrated the ability of RP‐HPLC to separate Ile‐ and allo‐Ile‐substituted analogs of a 26‐residue α‐helical antimicrobial peptide (AMP), with the substitution site towards the C‐terminus of the α‐helix. These peptides show different values of antibacterial activity and hemolytic activity, and different selectivity against bacteria and human cells. Our results underline the ability of RP‐HPLC to resolve even difficult diasteromeric peptide mixtures as well as its value in monitoring very subtle hydrophobicity changes in de novo‐designed AMP. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
164.
Dr. Colin R. Groom Dr. Frank H. Allen 《Angewandte Chemie (International ed. in English)》2014,53(3):662-671
The Cambridge Crystallographic Data Centre (CCDC) was established in 1965 to record numerical, chemical and bibliographic data relating to published organic and metal–organic crystal structures. The Cambridge Structural Database (CSD) now stores data for nearly 700 000 structures and is a comprehensive and fully retrospective historical archive of small‐molecule crystallography. Nearly 40 000 new structures are added each year. As X‐ray crystallography celebrates its centenary as a subject, and the CCDC approaches its own 50th year, this article traces the origins of the CCDC as a publicly funded organization and its onward development into a self‐financing charitable institution. Principally, however, we describe the growth of the CSD and its extensive associated software system, and summarize its impact and value as a basis for research in structural chemistry, materials science and the life sciences, including drug discovery and drug development. Finally, the article considers the CCDC’s funding model in relation to open access and open data paradigms. 相似文献
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Jinkyung Jung Colin Denniston Enzo Orlandini Julia M. Yeomans Corresponding author 《Liquid crystals》2013,40(12):1455-1462
We have studied domain growth in nematic liquid crystals using a lattice Boltzmann algorithm to solve the full, three-dimensional equations of hydrodynamics. An initially cylindrical V (bend) domain in an H (splay) state grows or shrinks anisotropically in agreement with experiment. A disclination loop forms at the mid-point of the wall surrounding the domain. We argue that different director configurations at different points on the loop lead to velocity anisotropy and show that both elastic effects and backflow are relevant. We discuss the dependence of the domain wall velocity on surface tilt and on the magnitude of an applied electric field. 相似文献
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Victoria E. Wright Fernando Castro-Gómez Ewa Jurneczko James C. Reynolds Andrew Poulton Steven D. R. Christie Perdita Barran Carles Bo Colin S. Creaser 《International Journal for Ion Mobility Spectrometry》2013,16(1):61-67
Collision cross sections (CCS) have been measured for three salen ligands, and their complexes with copper and zinc using travelling-wave ion mobility-mass spectrometry (TWIMS) and drift tube ion mobility-mass spectrometry (DTIMS), allowing a comparative size evaluation of the ligands and complexes. CCS measurements using TWIMS were determined using peptide and TAAH calibration standards. TWIMS measurements gave significantly larger CCS than DTIMS in helium, by 9 % for TAAH standards and 3 % for peptide standards, indicating that the choice of calibration standards is important in ensuring the accuracy of TWIMS-derived CCS measurements. Repeatability data for TWIMS was obtained for inter- and intra-day studies with mean RSDs of 1.1 % and 0.7 %, respectively. The CCS data obtained from IM-MS measurements are compared to CCS values obtained via the projection approximation, the exact hard spheres method and the trajectory method from X-ray coordinates and modelled structures using density functional theory (DFT) based methods. 相似文献
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Dr. Timothy A. Barendt Dr. Melissa L. Ball Dr. Qizhi Xu Dr. Boyuan Zhang Dr. Brandon Fowler Ayden Schattman Virginia Cary Ritter Prof. Michael L. Steigerwald Prof. Colin Nuckolls 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(17):3744-3748
This work presents a synergy between organic electronics and supramolecular chemistry, in which a host–guest complex is designed to function as an efficacious electronic material. Specifically, the noncovalent recognition of a fullerene, phenyl-C61-butyric acid methyl ester ( PC61BM ), by an alternating perylene diimide ( P )-bithiophene ( B ) conjugated macrocycle ( PBPB ) results in a greater than five-fold enhancement in electron mobility, relative to the macrocycle alone. Characterization and quantification of the binding of fullerenes by host PBPB is provided alongside evidence for intermolecular electronic communication within the host–guest complexes. 相似文献