全文获取类型
收费全文 | 38822篇 |
免费 | 4945篇 |
国内免费 | 3551篇 |
专业分类
化学 | 20456篇 |
晶体学 | 284篇 |
力学 | 1944篇 |
综合类 | 273篇 |
数学 | 3285篇 |
物理学 | 10620篇 |
无线电 | 10456篇 |
出版年
2024年 | 148篇 |
2023年 | 908篇 |
2022年 | 999篇 |
2021年 | 1315篇 |
2020年 | 1358篇 |
2019年 | 1276篇 |
2018年 | 1097篇 |
2017年 | 1046篇 |
2016年 | 1509篇 |
2015年 | 1593篇 |
2014年 | 1940篇 |
2013年 | 2556篇 |
2012年 | 3093篇 |
2011年 | 3121篇 |
2010年 | 2116篇 |
2009年 | 2141篇 |
2008年 | 2273篇 |
2007年 | 2151篇 |
2006年 | 1998篇 |
2005年 | 1720篇 |
2004年 | 1246篇 |
2003年 | 1134篇 |
2002年 | 1012篇 |
2001年 | 805篇 |
2000年 | 859篇 |
1999年 | 940篇 |
1998年 | 843篇 |
1997年 | 773篇 |
1996年 | 870篇 |
1995年 | 689篇 |
1994年 | 629篇 |
1993年 | 537篇 |
1992年 | 505篇 |
1991年 | 410篇 |
1990年 | 323篇 |
1989年 | 239篇 |
1988年 | 186篇 |
1987年 | 159篇 |
1986年 | 156篇 |
1985年 | 131篇 |
1984年 | 100篇 |
1983年 | 67篇 |
1982年 | 46篇 |
1981年 | 38篇 |
1980年 | 21篇 |
1978年 | 23篇 |
1977年 | 25篇 |
1976年 | 21篇 |
1975年 | 34篇 |
1974年 | 28篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
A novel polyimide (PI) based on 2,6-bis(p-aminophenyl)-benzo[1,2-d;5,4-d′]bisoxazole has been synthesized via a conventional two-stage procedure with bis(ether anhydrides) (HQDPA). The intermediate poly(amic acid) had inherent viscosities of 1.70 dl/g and could be thermally converted into light yellow polyimide film. The resulted polyimide showed excellent thermal stability, and the glass transition temperatures (Tg) were above 283 °C, the 5% weight loss temperature of the polymer was at 572 °C in N2. The thermal degradation of the polyimide was studied by thermogravimetric analysis (TGA) in order to determine the actual reaction mechanisms of the decomposition process. The activation energy of the solid-state process was determined using Flynn-Wall-Ozawa method, which does not require knowledge of the reaction mechanism, which resulted to be 361.36 kJ/mol. The activation energy of different mechanism models and pre-exponential factor (A) were determined by Coats-Redfern method. Compared with the value obtained from the Ozawa method, the actual reaction mechanism obeyed nucleation and growth model, Avrami-Erofeev function (A3) with integral form g(X) = [−ln(1−X)]3. 相似文献
992.
Huang Y Guler L Heidbrink J Kenttämaa H 《Journal of the American Chemical Society》2005,127(11):3973-3978
Gas-phase reactivity of five differently substituted positively charged phenyl radicals was examined toward six amino acids by using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR). The reactivity of the radicals studied was determined by the electrophilicity of the radical, which can be characterized by the radical's electron affinity (EA). The larger the electron affinity of the radical, the higher the overall reaction rate. In addition to the expected H-atom abstraction, several unprecedented reaction pathways were observed, including NH2 abstraction, SH abstraction, and SCH3 abstraction. These reaction pathways dominate for the most electrophilic radicals, and they may not follow radical but rather nucleophilic addition-elimination mechanisms. Hydrogen abstraction from glycine was also investigated theoretically. The results indicate that hydrogen abstraction from alphaC of glycine is both kinetically and thermodynamically favored over the NH2 group. The ordering of transition state energies for hydrogen abstraction from the alphaC and NH2 groups was found to reflect the radicals' EA ordering. 相似文献
993.
Separation of small peptides by hydrophilic interaction capillary electrochromatography (HI-CEC) has been investigated. The negative surface charge of a hydrophilic, strong-cation-exchange stationary phase (PolySULFOETHYL A) provided a substantial cathodic electroosmotic flow (EOF). The influence of acetonitrile content, ionic strength, mobile phase pH as well as applied voltage on the migration of the peptides was studied. Possible retention mechanisms of the peptides in HI-CEC were discussed. It was found that hydrophilic interaction between the solutes and the stationary phase played a major role in this system, especially when mobile phases with high acetonitrile content were used. However, an ion-exchange mechanism and electrophoretic mobility also affect the migration of the peptides in HI-CEC. Elution order and selectivity was proved to be different in HI-CEC and capillary zone electrophoresis (CZE), thus revealing the potential of HI-CEC as a complementary technique to CZE for the separation of peptides. Efficiency and selectivity of HI-CEC for the separation of peptides were demonstrated by baseline separating nine peptides in 6 min. 相似文献
994.
A resonance light scattering (RLS) imaging method was proposed based on imaging and measuring the RLS features of single suprahelical species of DNA, and its appfication to DNA assay was also investigated. In acidic medium, porphine-5,10,15,20-tetrakis(p-phenyltlimethylaminium) (PTPTMA), could stack along the molecular surface of DNA with the mode of long-range assembly to induce the formation of suprahelical species of DNA, resulting in strong RLS signals in the range of 450-510 nm. Under the excitation of 488 nm fight beam of argon ion laser source, single suprahelical species could be observed with the aid of a common microscope due to the strong scattered fight emitted by the suprahelical species. By capturing the RLS images of the single suprahelical species with a cooled charge coupled device (CCD) camera, and analyzing the RLS data, herein an RLS imaging method of DNA was proposed based on the linear relationship between the counts of suprahelical species in the detection focus plane and the concentration of DNA in nanograms. When 1.8 μmol/L PTPTMA was employed, both calf thymus DNA (ct DNA) and fish sperm DNA (fs DNA) in the range of 25-1100 ng/mL could be detected with the limits of detection lower than 25 ng/mL (3a). Four synthetic samples were detected satisfactorily with relative standard deviations less than 5.1%. 相似文献
995.
CrystalandMolecularStructureofaNewMono-substitutedTitanoceneComplex,{(η~5-Cp)[η~5-(1-(4-OCH_3)C_6H_4)C_6H_(10)Cp](TiCl_2)}·0.3(n-... 相似文献
996.
Tsann-Long Su Yu-Kun Yang Jai-Tung Huang Wu-Yun Ren Kyoichi A. Watanabe Ting-Chao Chou 《Journal of heterocyclic chemistry》1993,30(5):1437-1443
This paper is dedicated to the memory of Professor Roland K. Robins The synthesis of 4-[(1,3-diaminopyrrolo[3′,4′:4,5]pyrido[2,3-d]pyrimidin-8-yl)benzoyl]-L-glutamic acid ( 18 ), a potential antifolate and anticancer agent, has been achieved starting from 1,4-dibromobutan-2-ol with alkyl p-aminobenzoic acids. Condensation of these two agents gave 1-(4-alkoxycarbonylphenyl)pyrrolidin-3-ols 7a,b , which were oxidized to the corresponding pyrrolidin-3-one derivatives 8a,b . Compounds 8a,b were converted into 1,3-diamino-8-(4-alkoxycarbonylphenyl)-7,8-dihydro-9H-pyrrolo[3′,4′:4,5]pyrido[2,3-d]pyrimidines 12a,b in 4 steps. Saponification of 12b the benzoate ester and coupling with di-tert-butyl glutamate afforded a mixture of 7,8-dihydro product 16 and its aromatized derivative 17 . Finally hydrolysis of esters 16 or 17 gave only the title compound 18 . The 7,8-dihydro tricyclic derivatives were easily air-oxidized to form their fully aromatized compounds. The title compound 18 was one tenth less active than MTX against HL-60 cells in culture. 相似文献
997.
Self‐healing hydrogel such as polyacrylic acid (PAA) hydrogel has attracted increasing attention based on its promising potential applications. However, it usually suffers from low strength especially as mechanical device. Herein, a commercial microcrystalline cellulose (MCC) was modified with acrylamide to graft polyacrylamide (PAM) chains on the particle surface. The acrylamide‐modified MCC (AM‐MCC) was then dispersed in monomer solution of acrylic acid to prepare composite hydrogel. The mechanical properties of the obtained composite hydrogels and the self‐healed hydrogels were carefully measured by compressive and tensile tests, and by dynamic mechanical analysis. Our results demonstrate that introduction of a small amount of AM‐MCC such as 3 wt% can not only reinforce the original hydrogel and the healed hydrogel markedly, but also improve self‐healing efficiency obviously. The analyses indicate that in addition to the reversible multi‐interactions such as hydrogen bonding and ionic interactions, the entanglements between the PAA chains of the hydrogel matrix and the PAM chains grafted on the MCC particles have also played an important role on the improvement in mechanical performances and the healing ability of the hydrogel. Moreover, the responsiveness to exterior ion has been tested to indicate potential application of the composite hydrogel as self‐healable sensor. 相似文献
998.
Tao-Min Huang Chun-Hui Deng Ying-Jia Yu Xiao-Wei Zheng Geng-Li Duan 《Chromatographia》2006,63(11-12):551-556
An accurate, simple and sensitive method based on reversed-phase high-performance liquid chromatography with UV detection has been developed for determination of tiopronin (TP) in human plasma. TP in plasma was reacted with p-bromophenacyl bromide (p-BPB) to give the TP-p-BPB adduct and this derivative was then extracted from the plasma on a silica gel cartridge. Potential interfering compounds were removed by washing with water, and the TP-p-BPB adduct was then eluted with acetonitrile. The organic phase obtained was evaporated to complete dryness under a stream of nitrogen. The residue was dissolved in acetonitrile and this solution was injected on to a reversed-phase ODS HPLC column. The mobile phase was usually the ternary mixture acetonitrile–water–trifluoroacetic acid, 40:59.88:0.12 (v/v). The retention times of TP-p-BPB and the internal standard adduct were 14.4 and 17.9 min, respectively. No interfering peaks were encountered in several blank plasma samples examined. The limit of detection for TP was 12 ng mL?1. Extraction recovery exceeded 70%. The calibration plot for the TP derivative was linear in the range 40?4000 ng mL?1, regression coefficient 0.9989, and the coefficient of the variation of the points of the calibration plot was below 10%. The method was validated appropriately and successfully applied to the determination of TP in human plasma. 相似文献
999.
Xian‐Zhong Sun Zhen‐Li Huang He‐Zhou Wang Bao‐Hui Ye Xiao‐Ming Chen 《无机化学与普通化学杂志》2005,631(5):919-923
Two new coordination polymers [Cd(tdc)(bpy)(H2O)]n ( 1 ) and [Cd(tdc)(phen)]n ( 2 ) (H2tdc = thiophene‐2,5‐dicarboxylic acid, bpy = 2,2′‐bipyridine and phen = 1,10‐phenanthroline) have been synthesized under hydrothermal condition. Their crystal structures have been established by X‐ray single‐crystal diffraction. Complex 1 crystallizes in the orthorhombic space group Fdd2 with a = 14.757(7), b = 45.38(2), c = 10.518(5) Å, V = 7044(6) Å3, Z = 16; 2 in the monoclinic space group P21/c with a = 7.262(1), b = 21.970(2), c = 10.051(1) Å, β = 105.01(1)°, V = 1548.8(2) Å3, Z = 4. Both of them are double‐stranded chains and further assembled into three‐dimensional networks by π‐π stacking interactions. 1 and 2 are stable in air, and show blue photoluminescence at 415 nm and 410 nm, respectively. 相似文献
1000.
Chao J Meng D Li J Xu H Huang S 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2004,60(3):729-734
The interaction of ciprofloxacin with HP-beta-cyclodextrin (HP-beta-CD) has been studied by several analytical techniques, including 1H nuclear magnetic resonance (NMR), 13C NMR, fluorescence spectra, infrared spectroscopy, thermal analyzer and scanning electron microscope. In this paper, solid inclusion complex of ciprofloxacin with HP-beta-CD was synthesized by the coprecipitation method. In addition, the characterization of the inclusion complex has been proved by fluorimetry, infrared, differential scanning calorimetry and one-dimensional (1D), 2D NMR. The experimental results confirmed the existence of 1:1 inclusion complex of ciprofloxacin with HP-beta-CD. The formation constant of complex was determined by fluorescence method and 1H NMR. Spacial configuration of complex has been proposed on two-dimensional NMR technique. 相似文献