Potential influence on drug efficacy from interaction of tartrazine and trypsin

The extent to which drugs combine with trypsin is influenced by the interaction of tartrazine and trypsin, which may cause overdose or underdose of drugs. Therefore, the interaction of tartrazine and trypsin is investigated by methods of spectrometry in this paper. The binding rate of tartrazine to trypsin is 80.95–95.71% at 310?K, and Hill’s coefficients are almost 1. The effect of tartrazine on trypsin structure was studied by synchronous and circular dichroism. The results showed that the binding of tartrazine and trypsin induced the conformational change of trypsin, and quenched the endogenous fluorescence in trypsin. The results of molecular docking revealed that tartrazine is located in the catalytic active site of trypsin, and is consistent with that of experimental calculation.     

Synthesis, Characterization, DNA-Binding and Antiproliferative Activity of Nd(III) Complexes With N-(Nitrogen Heterocyclic) Norcantharidin Acylamide Acid

Three novel complexes [Nd(L)(NO₃)(H₂O)₂]·NO₃·2H₂O (HL¹ = N-pyrimidine norcantharidin acylamide acid, C₁₂H₁₃N₃O₄; HL² = N-pyridine norcantharidin acylamide acid, C₁₃H₁₄N₂O₄; HL³ = N-phenyl norcantharidin acylamide acid, C₁₄H₁₅NO₄) were synthesized. HL¹, HL² and HL³ are the ligand of complex(1), complex(2) and complex(3), respectively. Their structures were characterized by elemental analysis, conductivity measurement, infrared spectra and thermogravimetric analysis. The DNA-binding properties of the complexes have been investigated by fluorescence spectroscopy and viscosity measurements. The results suggest that the complexes can bind to DNA by partial intercalation. The liner Stern-Volmer quenching constant K_sq values are 3.3(±0.21)(1), 1.7(±0.19)(2) and 0.9(±0.04)(3), respectively. Complex (1) and (2) have been found to cleave pBR322 plasmid DNA at physiological pH and temperature. The test of antiproliferation activity indicates that complex(1) has strong antiproliferative ability against the SMMC7721 (IC₅₀ = 131.7 ± 23.4 μmol·L⁻¹) and A549 (IC₅₀ = 128.4 ± 19.9 μmol·L⁻¹) cell lines. The inhibition rates of complex(2) (IC₅₀ = 86.3 ± 11.3 μmol·L⁻¹) are much higher than that of NCTD (IC₅₀ = 115.5 ± 9.5 μmol·L⁻¹) and HL² (111.0 ± 5.7 μmol·L⁻¹) against SMMC7721 cell lines.     

Optimized temperature measurement with time-of-flight method

Driven by resonance probe light background Rubidium gas can emit fluorescence, which interacts with the falling atomic cloud in the temperature measurement with the time-of-flight (TOF) method and influence the experimental results. The dependencies of the acceleration and the temperature of the atomic cloud on the detuning of the probe beams were studied. We propose that the deviation of the acceleration from the gravity acceleration can be taken as a criterion of the accuracy of the temperature measurement using TOF method. Moreover, using the principle of the radiation force on the cold atomic cloud, one may measure the considerably weak intensity of the fluorescence.     

Chaos anticontrol and synchronization of three time scales brushless DC motor system

Chaos anticontrol of three time scale brushless dc motors and chaos synchronization of different order systems are studied. Nondimensional dynamic equations of three time scale brushless DC motor system are presented. Using numerical results, such as phase diagram, bifurcation diagram, and Lyapunov exponent, periodic and chaotic motions can be observed. By adding constant term, periodic square wave, the periodic triangle wave, the periodic sawtooth wave, and kx|x| term, to achieve anticontrol of chaotic or periodic systems, it is found that more chaotic phenomena of the system can be observed. Then, by coupled terms and linearization of error dynamics, we obtain the partial synchronization of two different order systems, i.e. brushless DC motor system and rate gyroscope system.     

New method for energy compensation of free electron laser

In this paper the theory of FEL operation in a longitudinal uniform magnetic field integrated with a synchronous precessing electro-magnetic field is expounded in view of the main problems in FEL development. A new energy compensation method is suggested as a new way and basis for the development of FEL research.     

Metamaterial absorber and extending absorbance bandwidth based on multi-cross resonators

In this paper, we report the design, simulation, and measurements of a broadband metamaterial absorber (MA) based on a periodic array of multi-layer cross-structure resonators. A perfect narrowband MA consists of cross-structure resonator, dielectric substrate, and continuous metal films, and the absorption frequency can be tunable by changing the geometrical parameters based on L-C resonance circuit theory. Furthermore, the absorption band of our design is effectively extended by simply stacking several such structural layers with different geometrical dimensions. Finally, the 4-layer cross-structure MA is only 2 mm, which can achieve a full width at half maximum (FWHM) bandwidth of 2 GHz by numerical simulations, and 90 % bandwidth of 1.9 GHz by experiments.     

Simulation of InGaN/GaN light-emitting diodes with a non-local quantum well transport model

Blue InGaN/GaN multiple quantum well (MQW) light-emitting diodes (LEDs) are simulated by the APSYS software with a non-local quantum well transport model which is used to describe the phenomenon that carriers can fly over the quantum wells directly. The simulation results based on this model are in good agreement with the experiment and show its significant influence on the output power, carrier transport, peak wavelength and current crowding effect of the InGaN/GaN MQW LEDs, indicating that the non-local quantum well transport plays an important role in these devices.     

Effects and Corrections for Mobile NMR Measurement

Nuclear magnetic resonance (NMR) under motion has drawn significant attention in recent years. Motion of the NMR probe has serious effects on NMR measurement. For example, NMR logging normally runs at downhole condition with tool motion at a speed of 30 ft/min. We propose here methods for motion corrections of NMR data based on the quantitative analysis of motion effects on polarization and echo acquisition. We also produced a multi-functional NMR scanning system to verify the theoretical analysis. Presented experiments demonstrate that the theoretical and experimental results match very well.     

一类扩张了的软弹簧型Duffing方程的紊动性态

本文用Melnikov函数方法讨论了一类扩张了的软弹簧型Duffing方程(k=1,2,3,…)在周期激励下的紊动现象.给出了出现二阶同宿切的条件.文中所采用的方法对于不能给出并宿轨道的显式的系统的研究是非常有用的.     

对流扩散方程一类改进的特征线修正有限元方法

１引言在地下水污染,地下渗流驱动,核污染,半导体等问题的数值模拟中,均涉及抛物型对流扩散方程（或方程组）的数值求解问题．这些对流扩散型偏微分方程（或方程组）具有共同的特点：对流的影响远大于扩散的影响,即对流占优性,对流占优性给问题的数值求解带来许多困难,因此对流占优问题的有效数值解法一直是计算数学中重要的研究内容．用通常的差分法或有限元法进行数值求解将出现数值振荡．为了克服数值振荡,提出各种迎风方法和修正的特征方法并在这些问题上得到成功的实际应用、８０年代,Ｄｏｕｇｌａｓ和Ｒｕｓｓｅｌｌ［２］等…