核电站反应堆松脱件模拟撞击技术研究

核电站松脱件撞击模拟系统可在反应堆系统管壁或器壁上制造出松脱件撞击信号,用以在线调试和检测电站松脱部件监测系统,保证核电站的正常运行.利用电容放电特性,产生高能量的脉冲电流;基于电磁效应原理,将脉冲电能转换为机械动能,实现了核电站松脱件撞击模拟技术;通过试验验证,利用该技术可产生0~100g的核电站松脱件模拟撞击信号.     

Natural Products in Preventing Tumor Drug Resistance and Related Signaling Pathways

Drug resistance is still an obstacle in cancer therapy, leading to the failure of tumor treatment. The emergence of tumor drug resistance has always been a main concern of oncologists. Therefore, overcoming tumor drug resistance and looking for new strategies for tumor treatment is a major focus in the field of tumor research. Natural products serve as effective substances against drug resistance because of their diverse chemical structures and pharmacological effects. We reviewed the signaling pathways involved in the development of tumor drug resistance, including Epidermal growth factor receptor (EGFR), Renin-angiotensin system (Ras), Phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt), Wnt, Notch, Transforming growth factor-beta (TGF-β), and their specific signaling pathway inhibitors derived from natural products. This can provide new ideas for the prevention of drug resistance in cancer therapy.     

基于高性能编码调制映射的联合解调译码方法

对于功率受限的加性高斯白噪声（Additive White Gaussian Noise,AWGN）信道,当具有高斯分布的信号作为信道输入时,信息传输性能接近信道容量.为了传输性能接近容量限,本文采用优化的非均匀排布APSK（Amplitude Phase Shift Keying）星座取代传统的多维QAM（Quadrature Amplitude Modulation）调制星座图,利用二进制交换算法（Binary Switching Algorithm,BSA）进行星座图的反馈后哈姆尼克均值优化,设计了一种新型的"4+12F-APSK"非均匀排布的星座映射方案,并与BICM-ID（Bit Interleaved Coded Modulation-Iterative Decoding）解调译码相结合,提出了基于高性能编码调制映射的联合解调译码方法,有效地解决了接近信道容量限的联合解调译码的难题.实验结果表明,在瑞利衰落信道误比特率在10的-5次方量级时,该方法比传统的MSEW（Maximum Squared Euclidean Weight）,GRAY,SP（Set Partitioning）三种矩形QAM调制方案的译码性能至少改善0.6dB;在AWGN信道误比特率在10的-3次方量级时,该方法比传统的MSEW和GRAY映射至少改善0.3dB.同时,与其他16APSK映射方案相比,该方法无论是在瑞丽衰落信道还是在AWGN信道条件下,在相同的误比特率量级上,都具有1dB~2dB的译码性能增益,有效地逼近了传输容量限.该方法在移动通信和电视广播通信等资源有限网络中具有广泛的应用前景.     

低温卷取钢坯头部和尾部跟踪智能控制技术的研究

随着现代热连轧生产工艺的不断提高,对热轧卷取机的控制系统也提出了更高要求。基于改进卷取带钢低温跟踪检测技术和减小咬钢时的头部打滑的目的,采用了智能控制方案能够动态调整控制器参数的方法,通过MAT-LAB/SIMULINK系统仿真的试验,实现了带钢在200~300℃可以正常卷取,批量生产出热轧双相钢。     

低聚壳聚糖几何结构和物理化学属性的理论研究

运用密度泛函B3LYP/6-31G+(d)方法对gg构象的低聚壳聚糖进行了结构优化、频率计算和电子结构,并用更高精度的WB97XD/6-311+G(d,p)方法计算了平均结合能及零点能校正,分析了热力学性质.结果表明,由于低聚壳聚糖中的氢键作用,使其形成螺旋结构;聚合度的增加,使平均结合能随之下降,结构的稳定性增强;在降解过程中,均为放热反应,验证了利用降温来提高降解产率的实验的可行性;此外,聚合度的增加,使能隙减小且快速收敛于聚合度为7的6.99 eV,稳定的反应活性与实验相符;HOMO、LUMO的电子密度分布表明,化学活性集中在C2位的氨基、C6位的羟基以及链的两端位置.该结果对低聚壳聚糖模型的建立和低聚壳聚糖降解过程、活性位置以及物理化学属性的尺寸依赖等现象的研究有着指导意义.     

面向卫星-地面协同通信系统的物理层安全传输设计

为增强多窃听者场景下的卫星-地面协同通信系统数据传输安全性,首先建立以卫星链路物理层安全传输速率最大化为优化准则、地面链路传输质量和信号发送功率为约束条件的卫星-地面协同传输优化问题.由于该优化问题的非凸性,随后通过引入辅助变量,将原问题分解为主、次两个子问题进行迭代求解,其中主问题为一维搜索问题,次问题则需进一步借助半正定松弛和矩阵变换方法转换为等价凸优化问题.最终,提出一种基于物理层安全的卫星-地面协同传输设计方案.计算机仿真结果表明,信号发射功率和卫星天线数的增加可提升系统安全速率,而窃听者数量的增加则会使得系统安全性降低.     

In vitro metabolism study of Strychnos alkaloids using high‐performance liquid chromatography combined with hybrid ion trap/time‐of‐flight mass spectrometry

In this report, the in vitro metabolism of Strychnos alkaloids was investigated using liquid chromatography/high‐resolution mass spectrometry for the first time. Strychnine and brucine were selected as model compounds to determine the universal biotransformations of the Strychnos alkaloids in rat liver microsomes. The incubation mixtures were separated by a bidentate‐C₁₈ column, and then analyzed by on‐line ion trap/time‐of‐flight mass spectrometry. With the assistance of mass defect filtering technique, full‐scan accurate mass datasets were processed for the discovery of the related metabolites. The structural elucidations of these metabolites were achieved by comparing the changes in accurate molecular masses, calculating chemical component using Formula Predictor software and defining sites of biotransformation based upon accurate MSⁿ spectral information. As a result, 31 metabolites were identified, of which 26 metabolites were reported for the first time. These biotransformations included hydroxylation, N‐oxidation, epoxidation, methylation, dehydrogenation, de‐methoxylation, O‐demethylation, as well as hydrolysis reactions. Copyright © 2013 John Wiley & Sons, Ltd.     

N-substituted-3(10H)-acridones as visible-light photosensitizers for organic photoredox catalysis

N-Substituted-3(10H)-acridones have been established as visible-light organic photocatalyst. These photosensitizers are efficient for oxidative coupling reaction of N-aryl tetrahydroisoquinolines with various nucleophiles. Notably, N-methyl-3(10H)-acridone (Ia) is stable and can be effectively prepared. It is a water-soluble and atom-economic catalyst, and thus holds promise for green chemical applications. Mechanistic studies confirm a single electron transfer (SET)-induced radical process and a rate-limiting step. Analysis of the photocatalytic reactivity?structure relationship reveals that the acridones are robust and tunable photosensitizers for photoredox catalysis.