Analysis of performance optimization in supercontinuum sources

We have determined the cause of performance variation as a function of system parameters in supercontinuum (SC) sources in a normal-dispersion fiber by numerically analyzing the noise evolution of the SC. High-order nonlinearity was considered in such an analysis for the first time to our knowledge. We found that the evolution of noise along the SC fiber has two stages: First, the noise is governed by dispersion, which is different from that of the signal, whereas self-steeping leads to an asymmetric noise distribution across the spectrum. Second, four-wave mixing generates new noise components, whereas Raman scattering augments the asymmetry. We evaluated the qualities of the spectrally sliced pulses at several stages to verify the analysis and found an asymmetric profile of the sliced-pulses' quality versus frequency.     

Optoacoustic imaging with synthetic aperture focusing and coherence weighting

Optoacoustic imaging takes advantage of high optical contrast and low acoustic scattering and has found several biomedical applications. In the common backward mode a laser beam illuminates the image object, and an acoustic transducer located on the same side as the laser beam detects the optoacoustic signal produced by thermoelastic effects. A cross-sectional image is formed by laterally scanning the laser beam and the transducer. Although the laser beam width is generally narrow to provide good lateral resolution, strong optical scattering in tissue broadens the optical illumination pattern and thus degrades the lateral resolution. To solve this problem, a combination of the synthetic aperture focusing technique with coherence weighting is proposed. This method synthesizes a large aperture by summing properly delayed signals received at different positions. The focusing quality is further improved by using the signal coherence as an image quality index. A phantom comprising hair threads in a 1% milk solution was imaged with an optoacoustic imaging system. The results show that the proposed technique improved lateral resolution by 400-800% and the signal-to-noise ratio by 7-23 dB over conventional techniques.     

Multiharmonic-generation biopsy of skin

Because it avoids the in-focus photodamage and phototoxicity problem of two-photon-fluorescence excitation, multiharmonic-generation biopsy based on a 1200-1300-nm light source could provide a truly noninvasive and highly penetrative optical sectioning of skin. We study multiharmonic-generation biopsy of fixed mouse skin. Our preliminary study suggests that this technique could provide submicrometer-resolution deep-tissue noninvasive biopsy images in skin without the use of fluorescence and exogenous markers.     

Near-field scanning optical microscopy imaging of multimode interference

By use of a near-field scanning optical microscope (NSOM) in collection mode, the intensity distribution along a 2 x 2 multimode interference coupler was directly imaged as a function of wavelength. Although calculations can predict the general trend of wavelength dependence and the approximate positions of multiple images in the coupler, the accuracy is poor because of uncertainties in the waveguide width. We show that direct imaging using a NSOM bypasses calculational uncertainties and proves to be a powerful technique for studying these waveguide devices.     

At-sea measurements of sound penetration into sediments using a buried vertical synthetic array

Acoustic bottom penetration experiments were carried out in a medium-grain sandy bottom at a site in St. Andrews Bay, Florida. These investigations used a new buried, vertical, one-dimensional synthetic array system where a small hydrophone was water-jetted into the sediment to a depth of approximately 2 m. Once buried, this hydrophone was mounted to a vertical robotics stage that translated the hydrophone upward in 1-cm increments. A broadband (3 to 80 kHz) spherical source, positioned 50 cm above the sediment-water interface, was used to insonify the sediment. Measurements were made with insonification angles above and below the critical angle by changing the horizontal distance of the source relative to the insertion point. This new measurement system is detailed, and results are presented that include temporal, frequency, and wavenumber analysis for natural and roughened interfaces. The measured compressional sound speed and attenuation are shown to be self-consistent using the Kramers-Kronig relation. Furthermore, only a single fast compressional wave was observed. There was no observation of a second slower compressional wave as predicted by some applications of the Biot model to unconsolidated water-saturated porous media.     

Transition from Kardar-Parisi-Zhang to tilted interface critical behavior in a solvable asymmetric avalanche model

We use a discrete-time formulation of the asymmetric avalanche process (ASAP) [Phys. Rev. Lett. 87, 084301 (2001)]] of p particles on a finite ring of N sites to obtain an exact expression for the average avalanche size as a function of toppling probabilities and particle density rho=p/N. By mapping the model onto driven interface problems, we find that the ASAP incorporates the annealed Kardar-Parizi-Zhang and quenched tilted interface dynamics for rhorho(c), respectively, with rho(c) being the critical density for given toppling probabilities and N--> infinity. We analyze the crossover between two regimes and show which parameters are relevant near the transition point.     

Global nature of dilute-to-dense transition of granular flows in a 2D channel

The dilute-to-dense transition of granular flow of particle size d(0) is studied experimentally in a two-dimensional channel (width D) with confined exit (width d). Our results show that with fixed d and D there is a maximum inflow rate Q(c) above which the flow changes from dilute to dense and the outflow rate drops abruptly from Q(c) to a dense rate Q(d). A rescaled critical rate q(c) is found to be a function of a scaling variable lambda only: q(c) approximately F(lambda), where lambda identical with d/d(0) d/D-d. This form of lambda suggests that the dilute-to-dense transition is a global property of the flow, unlike the jamming transition which depends only on d/d(0). Furthermore, the transition is found to occur when the area fraction of particles near the exit exceeds a critical value which is close to 0.65+/-0.03.     

Advanced flicker spectroscopy of fluid membranes

The bending elasticity of a fluid membrane is characterized by its modulus and spontaneous curvature. We present a new method, advanced flicker spectroscopy of giant nonspherical vesicles, which makes it possible to simultaneously measure both parameters for the first time. Our analysis is based on the generation of a large set of reference data from Monte Carlo simulations of randomly triangulated surfaces. As an example of the potential of the procedure, we monitor thermal trajectories of vesicle shapes and discuss the elastic response of zwitterionic membranes to transmembrane pH gradients. Our technique makes it possible to easily characterize membrane curvature as a function of environmental conditions.     

Effects of air on the segregation of particles in a shaken granular bed

Effects of interstitial air on the motions of a large intruder in a shaken granular bed are studied experimentally as a function of ambient air pressure, particle size of the bed, and the density of the intruder. It is found that the intruder always rises from the granular bed in the absence of air. However, the intruder can acquire both positive and negative buoyancy in the presence of air. Negative buoyancy can be observed only when both the density of the intruder and the particle size of the bed are small enough. This negative buoyancy can be explained by the unusual air pressure distribution found in the bed.     

Lasonolide A: structural revision and total synthesis

The proposed structure of lasonolide A was synthesized employing radical cyclization reactions of beta-alkoxyacrylates for preparation of the tetrahydropyranyl units A and B, but the spectroscopic data did not match those of the natural product. Both enantiomers of a revised structure featuring 17E,25Z double bonds were synthesized, and the (-)-isomer was found to be the biologically active enantiomer.