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131.
J. Brian Pitts 《General Relativity and Gravitation》2010,42(3):601-622
The problem of finding a covariant expression for the distribution and conservation of gravitational energy–momentum dates to the 1910s. A suitably covariant infinite-component localization is displayed, reflecting Bergmann’s realization that there are infinitely many conserved gravitational energy–momenta. Initially use is made of a flat background metric (or rather, all of them) or connection, because the desired gauge invariance properties are obvious. Partial gauge-fixing then yields an appropriate covariant quantity without any background metric or connection; one version is the collection of pseudotensors of a given type, such as the Einstein pseudotensor, in every coordinate system. This solution to the gauge covariance problem is easily adapted to any pseudotensorial expression (Landau–Lifshitz, Goldberg, Papapetrou or the like) or to any tensorial expression built with a background metric or connection. Thus the specific functional form can be chosen on technical grounds such as relating to Noether’s theorem and yielding expected values of conserved quantities in certain contexts and then rendered covariant using the procedure described here. The application to angular momentum localization is straightforward. Traditional objections to pseudotensors are based largely on the false assumption that there is only one gravitational energy rather than infinitely many. 相似文献
132.
133.
Nigel J. Brookes Dr. Alireza Ariafard Dr. Robert Stranger Prof. Brian F. Yates Prof. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2010,16(27):8117-8132
The experimentally known reduction of carbon monoxide using a 3‐coordinate [Ta(silox)3] (silox=OSi(tBu)3) complex initially forms a ketenylidene [(silox)3Ta? CCO], followed by a dicarbide [(silox)3Ta? CC? Ta(silox)3] structure. The mechanism for this intricate reaction has finally been revealed by using density functional theory, and importantly a likely structure for the previously unknown intermediate [(silox)3Ta? CO]2 has been identified. The analysis of the reaction pathway and the numerous intermediates has also uncovered an interesting pattern that results in CO cleavage, that being scission from a structure of the general form [(silox)3Ta? CnO] in which n is even. When n is odd, cleavage cannot occur. The mechanism has been extended to consider the effect of altering both the metal species and the ligand environment. Specifically, we predict that introducing electron‐rich metals to the right of Ta in the periodic table to create mixed‐metal dinuclear intermediates shows great promise, as does the ligand environment of the Cummins‐style 3‐coordinate amide structure. This latter environment has the added complexity of improved electron donation from amide rotation that can significantly increase the reaction exothermicity. 相似文献
134.
Alexander N. Zaykov Brian V. Popp Dr. Zachary T. Ball Prof. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2010,16(22):6651-6659
The use of carboxylate side chains to induce peptide helicity upon binding to dirhodium centers is examined through experimental and computational approaches. Dirhodium binding efficiently stabilizes α helicity or induces α helicity in otherwise unstructured peptides for peptides that contain carboxylate side chains with i, i+4 spacing. Helix induction is furthermore possible for sequences with i, i+3 carboxylate spacing, though in this case the length of the side chains is crucial: ligating to longer glutamate side chains is strongly helix inducing, whereas ligating the shorter aspartate side chains destabilizes the helical structure. Further studies demonstrate that a dirhodium metallopeptide complex persists for hours in cellular media and exhibits low toxicity toward mammalian cells, enabling exploitation of these metallopeptides for biological applications. 相似文献
135.
Suresh Kavya Islam Muhammad Amirul Rastgar Masoud Mohammadnezhad Ameneh Fleck Brian A. Sadrzadeh Mohtada 《Cellulose (London, England)》2022,29(6):3351-3374
Cellulose - The sustainable development of oil–gas and petrochemical industries necessitates the development of cost-effective and eco-friendly technologies to treat mass-produced oily... 相似文献
136.
Zhu Kai Li Cui Wu Kingsley Y. Mohr Christopher Li Xun Lanman Brian 《Journal of computer-aided molecular design》2022,36(8):591-604
Journal of Computer-Aided Molecular Design - KRAS has long been referred to as an ‘undruggable’ target due to its high affinity for its cognate ligands (GDP and GTP) and its lack of... 相似文献
137.
Jiyeon Park Dongmoung Kim Jin-Ok Lee Hyeon-Chun Park Brian Y. Ryu Ju Han Kim Sug Hyung Lee Yeun-Jun Chung 《Experimental & molecular medicine》2022,54(3):263
Despite growing evidence of the relevance of alternative splicing (AS) to cancer development and progression, the biological implications of AS for tumor behaviors, including papillary thyroid cancer (PTC), remain elusive. With the aim of further understanding the molecular and histological subtypes of PTC, we in this study explored whether AS events might act as new molecular determinants. For this purpose, AS profiles were analyzed in RNA-sequencing data from The Cancer Genome Atlas (TCGA) and from a Korean patient dataset. A total of 23 distinct exon-skipping (ES) events that correlated significantly with PTC oncogenic activity and differentiation scores were identified. The two top-ranked ES events, NUMA1_17515 in exon 18 of NUMA1 and TUBB3_38175 in exon 6 of TUBB3, showed high correlations with oncogenic activities and discriminated histological and molecular subtypes of PTC. Furthermore, two novel intron-retention (IR) events for TUBB3 were uncovered. All ES and IR events for the TUBB3 gene were predicted to induce nonsense-mediated mRNA decay. The relative abundances of intron reads in the PTC dataset from TCGA showed IR levels to differ significantly among PTC subtypes, possibly reflecting their different tumor behaviors. This study provides a landscape of AS changes among PTC subtypes and identified two significant AS events, NUMA1_17515 and TUBB3_38175, as potential AS biomarkers for PTC subclassification and characterization. The AS events identified in this study may be involved in the development of phenotypic differences underlying the functional characteristics and histological differentiation of PTCs.Subject terms: Cancer genomics, RNA splicing 相似文献
138.
Michael I. Bruce Omar bin Shawkataly Brian K. Nicholson 《Journal of organometallic chemistry》1985,286(3):427-437
H2Ru3(μ3-S)(CO)9 is deprotonated by K[HBBus3] to give cluster anions which react with [O{Au(PPh3)}3]+ or with AuCl(PPh3)/T1+ to give HRu3Au(μ3-S)(CO)9(PPh3) (1) and Ru3Au2(μ3-S)(CO)9(PPh3)2 (3). A similar sequence with HRu3(μ3-SBut)(CO)9 leads to Ru3Au(μ3-SBut)(CO)9(PPh3) (2) as the main product although some 1 also forms, indicating SC cleavage competes with deprotonation of HRu3(μ3-SBut)(CO)9 by [HBBus3]?. The X-ray crystal structures of 1, 2 and 3 are described; (1) and (2) have “butterfly” AuRu3 cores with markedly different hinge angles of 119 and 148° respectively, while 3 has a trigonal-bipyramidal Au2Ru3 skeleton. All three clusters have the sulphur atom symmetrically bridging the Ru3 triangular face. 相似文献
139.
Effect of Dosimetric and Physiological Factors on the Lethal Photosensitization of Porphyromonas gingivalis in vitro 总被引:4,自引:0,他引:4
Manpreet Bhatti Alexander MacRobert Sajeda Meghji Brian Henderson Michael Wilson 《Photochemistry and photobiology》1997,65(6):1026-1031
The aims of this study were to (1) determine the effect of dosimetric and physiological factors on the lethal photosensitization of Porphyromonas gingivalis using tolui-dine blue O (TBO) and light from a helium/neon (HeNe) laser; (2) determine the influence of sensitizer concentration, preirradiation time, serum and growth phase on sensitizer uptake by P. gingivalis. The dosimetric factors studied were concentration of TBO, light dose and preirradiation time. The physiological factors were presence of serum, pH and bacterial growth phase. Sensitizer uptake by P. gingivalis under various conditions was determined using tritiated TBO (3H-TBO). In the presence of TBO, a light dose-dependent increase in kill was attained (100% kill at 4.4 J). There was no significant effect on the numbers killed when TBO was increased from 12.5 to 50 µg/mL. An increase in preirradiation time gave slightly increased kills. High kills were achieved at all three pH (6.8–8.0). Although kills were substantial in the presence of serum, they were significantly less than those obtained in the presence of saline. Cells in all three growth phases were susceptible to lethal photosensitization, although stationary phase cells were slightly less susceptible. Maximum uptake of TBO occurred within 60 s and uptake in serum was less than in saline. The uptake by the log phase cells was greater at lower concentrations of sensitizer (50 µg/mL), compared to the other two phases. 相似文献
140.
Michael A. Brook Jianxiong Jiang Philippa Heritage Brian Underdown Mark R. McDermott 《Colloids and surfaces. B, Biointerfaces》1997,9(6):391-295
Silicone-coated starch/protein (human serum albumin, HSA) microparticles were prepared by precipitation of a starch/HSA/DMSO/water (water-in-oil) emulsion into acetone containing a silicone: the silicone polymer was either unfunctionalized (SiMe3 terminated, PDMS) or functionalized at its termini with Si(OEt)3 groups (TES-PDMS). The microparticles of approximate diameter 2–7 μm were highly hydrophobic with advancing contact angles 115°. Over several minutes, however, the contact angle decreased to ca. 40–70°. Soxhlet extraction with water led to degradation of the microparticles, irrespective of the nature of their silicone coating, as evidenced by release of the protein from them. Intraperitoneal (IP) or gastric administration of the two different particles to mice, however, showed a clear difference between the two silicones. The microparticles coated with either PDMS or TES-PDMS led to very different immune responses. Oral administration of the microparticles prepared with functionalized silicone elicited a significant production of antibodies, whereas the particles prepared with the unfunctionalized silicone (PDMS) were only weakly active. By contrast, the IP results demonstrated that particles coated with PDMS elicited an immune response that was established much more rapidly than with the particles modified with TES-PDMS. It is proposed that the TES-PDMS forms a physically adhering film or covalent bond to the protein molecules, which serves to protect the microparticle from biological degradation in the gut and/or facilitates the microparticle/protein interaction with the immune system. 相似文献