Cost-benefit analysis of a single server three-unit redundant system with inspection, delayed replacement and two types of repair

This paper deals with a redundant system with two types of spare units—a warm standby unit for instantaneous replacement at the time of failure of the active unit and a cold standby (stock) unit which can be replaced after a random amount of time. The type of the failure of operative or warm standby unit is detected by inspection only. The service facility plays the triple role of replacement, inspection and repair of a unit. Failure time distributions of operative and warm standby units are negative exponential whereas the distributions of replacement time, inspection time and repair times are arbitrary. The system has been studied by using regenerative points.     

Two colour multiphoton ionization spectroscopy of uranium from a metastable state

Using two pulsed tunable dye lasers, a two colour multiphoton ionization process has been utilised to explore the higher energy levels of uranium. One hundred and thirty eight new UI levels have been observed in the 37540–38420 cm^–1 region. J assignments of these levels have been suggested on the basis of their excitation from intermediate levels with known and contiguous J values. In eight cases the J assignments are unique.     

Estimation of the dynamical properties of polyurethane foam through use of Prony series

A system identification procedure is formulated for estimation of parameters associated with a dynamic model of a single-degree-of-freedom foam-mass system. The foam is modelled as a linear viscoelastic material, whose constitutive law is expressed by an exponential hereditary relaxation kernel. The identification procedure is based on modelling the free response of the system as a Prony series (sum of exponentials terms) and fitting this Prony series to the data. This estimated response model is then utilized to estimate the parameters in the system model based on an explicit solution of the model. The procedure is analyzed for its reliability under different sources of error and uncertainties, such as the presence of weak components and experimental noise, and some modifications are evaluated to improve the robustness of the procedure. Finally, the procedure is applied to experimental data to obtain relevant stiffness, viscous and viscoelastic parameters associated with the system. Variations in values of these parameters as a function of static compression are also investigated.     

Promising anticancer drug thapsigargin: A perspective toward the total synthesis

The guaianolide ring containing sesquiterpene thapsigargin is found in the roots and fruits of Mediterranean plant Thapsia garganica L. It is known for its activity as a potent antagonist for Ca²⁺-ATPase (sarco–endoplasmic reticulum Ca²⁺-ATPase) inhibition. Recently, a prodrug mipsagargin is being investigated to target the blood vessel of the cancer cells for the treatment of tumors. The limited natural supply (low isolation and only localized growth (Mediterranean area)) from the natural sources strongly urges for the development of chemical synthetic strategies to access these natural products. This review pertain the various strategies used so far in the thapsigargin’s synthesis, focusing on major contributions in the total synthesis till date.     

A Dual-Band Circularly Polarized Hexagonal Ring Antenna for Handheld RFID Readers

In this paper, a compact, lightweight, low-profile dual-band circularly polarized antenna is presented for handheld radio frequency identification (RFID) readers. The proposed antenna consists of two concentric hexagonal rings and a feed network printed on different layers of the dielectric substrate. The antenna configuration exploits a stacked-coupled technique for gain enhancement and single-port feeding for easy manufacturing. The center frequencies of the two resonating bands are 0.92 GHz (UHF) and 2.45 GHz (ISM). The antenna exhibits circular polarization characteristics in both the resonating bands, therefore encountering the losses due to polarization mismatch and increasing the tag detection reliability. A prototype of the proposed RFID antenna is simulated and fabricated, and experimental results are in close agreement. The peak antenna gain is 3.3 dB and 5 dB in the UHF and ISM bands, respectively. The overall size of the RFID antenna is 80 mm?×?80 mm?×?7.76 mm.

     

Aromatic-aliphatic copolyesters—II. Various polycondensation processes

Aromatic aliphatic copolyesters, using hydroquinone, resorcinol, 4,4′-dihydroxybiphenyl (DHBP) 2,2 bis(4-hydroxyphenyl)propane and 4,4′-dihydroxydiphenyl sulphone (DHDPS) as bisphenols and ethylene glycol as diol, have been synthesized by interfacial, low temperature and high temperature solution condensation. Relative reactivities of these bisphenols and ethylene glycol have been evaluated by various polycondensation methods at a fixed ratio of bisphenol/glycol. Decrease in the extent of polymerization and viscosity was observed by incorporation of aliphatic diol. Viscosity was also influenced by the chemical structure of the bisphenol.     

Selective oxidation of cyclohexane by a Ru(III) analogue of the gif-system. RuIIIacetic acid-pyridine-KHSO5

Selective oxidation of cyclohexane to cyclohexanone was carried out in a RuCl₃-pyridine-acetic acid-KHSO₅ mixture. This system yields 2.8% of cyclohexanone (based on oxone concentration) under the conditions employed. Mechanistic postulate for the oxidation reaction involves the formation of a carbene intermediate (Ru=C) prior to the ketone formation.     

Cell Penetrating Synthetic Antimicrobial Peptides (SAMPs) Exhibiting Potent and Selective Killing of Mycobacterium by Targeting Its DNA

Naturally occurring antimicrobial peptides (AMPs) are powerful defence tools to tackle pathogenic microbes. However, limited natural production and high synthetic costs in addition to poor selectivity limit large‐scale use of AMPs in clinical settings. Here, we present a series of synthetic AMPs (SAMPs) that exhibit highly selective and potent killing of Mycobacterium (minimum inhibitory concentration <20 μg mL^?1) over E. coli or mammalian cells. These SAMPs are active against rapidly multiplying as well as growth saturated Mycobacterium cultures. These SAMPs are not membrane‐lytic in nature, and are readily internalized by Mycobacterium and mammalian cells; whereas in E. coli, the lipopolysaccharide layer inhibits their cellular uptake, and hence, their antibacterial action. Upon internalization, these SAMPs interact with the unprotected genomic DNA of mycobacteria, and impede DNA‐dependent processes, leading to bacterial cell death.