Direct STM investigation of cinchona alkaloid adsorption on Cu(III)

Scanning tunneling microscopy (STM) combined with cyclic voltammetry has been employed to investigate the adsorption of cinchonine on Cu(111). Similar to cinchonidine, cinchonine forms a long-range ordered adlayer with (4 x 4) symmetry on the substrate. The structural details on molecular adsorption were obtained by high-resolution STM images. On the basis of the previous results and obtained STM images, the quinoline ring is proposed to lie parallel to Cu(111) and serve as an anchoring group. The chiral quinuclidine moiety extends out of the surface to facilitate the interaction with the prochiral reactants.     

1mm SiC多指栅微波功率器件

研制了4H-SiC MESFET 1mm多栅器件.通过对SiC关键工艺技术进行研究,设计出初步可行的工艺流程,并且制作出单栅宽100μm,总栅宽1mm,栅长0.8μm的n沟道4H-SiC MESFET,其微波特性测试结果为:在2GHz,Vds=30V时,最大输出功率为1.14W,相应增益为4.58dB,功率附加效率为19%,漏极效率为28.7%.     

A Fault Detection Method for Electrohydraulic Switch Machine Based on Oil-Pressure-Signal-Sectionalized Feature Extraction

A turnout switch machine is key equipment in a railway, and its fault condition has an enormous impact on the safety of train operation. Electrohydraulic switch machines are increasingly used in high-speed railways, and how to extract effective fault features from their working condition monitoring signal is a difficult problem. This paper focuses on the sectionalized feature extraction method of the oil pressure signal of the electrohydraulic switch machine and realizes the fault detection of the switch machine based on this method. First, the oil pressure signal is divided into three stages according to the working principle and action process of the switch machine, and multiple features of each stage are extracted. Then the max-relevance and min-redundancy (mRMR) algorithm is applied to select the effective features. Finally, the mini batch k-means method is used to achieve unsupervised fault diagnosis. Through experimental verification, this method can not only derive the best sectionalization mode and feature types of the oil pressure signal, but also achieve the fault diagnosis and the prediction of the status of the electrohydraulic switch machine.     

THE EFFECTIVE RANGE OF K-FAULT DIAGNOSIS OF-LINEAR CIRCUITS

In view of K-fault testability,the topological construction of a practical circuitis far from ideal.In order to improve the testability of a circuit,we may increase the numberof accessible nodes or use the multi-excitation method.Effectiveness of these methods and thefeasibility of choosing accessible nodes are discussed in detail.The conditions for multi-excitationtestability are presented.     

ZnLiFeO_3高温热敏厚膜材料的研究

ＺｎＬｉＦｅＯ３（ＺＬＦ）高温ＮＴＣ热敏厚膜材料，是以尖晶石结构的ＺｎＬｉＦｅＯ３导电陶瓷作厚膜浆料的导电相，以Ａｌ２Ｏ３瓷为基体，用厚膜工艺制成的。实验表明，在氮气中烧结的ＺＬＦ厚膜材料，室温方阻１０３Ω／□级，Ｂ值约１０００Ｋ。在高温５００～７００℃范围内，方阻降为１０２Ω／□级，Ｂ值仍小于１０００Ｋ。是一种很有前途的高温热敏材料。     

Structural and Functional Analysis of the Pyridoxal Phosphate Homeostasis Protein YggS from Fusobacterium nucleatum

Pyridoxal 5′-phosphate (PLP) is the active form of vitamin B6, but it is highly reactive and poisonous in its free form. YggS is a PLP-binding protein found in bacteria and humans that mediates PLP homeostasis by delivering PLP to target enzymes or by performing a protective function. Several biochemical and structural studies of YggS have been reported, but the mechanism by which YggS recognizes PLP has not been fully elucidated. Here, we report a functional and structural analysis of YggS from Fusobacterium nucleatum (FnYggS). The PLP molecule could bind to native FnYggS, but no PLP binding was observed for selenomethionine (SeMet)-derivatized FnYggS. The crystal structure of FnYggS showed a type III TIM barrel fold, exhibiting structural homology with several other PLP-dependent enzymes. Although FnYggS exhibited low (<35%) amino acid sequence similarity with previously studied YggS proteins, its overall structure and PLP-binding site were highly conserved. In the PLP-binding site of FnYggS, the sulfate ion was coordinated by the conserved residues Ser201, Gly218, and Thr219, which were positioned to provide the binding moiety for the phosphate group of PLP. The mutagenesis study showed that the conserved Ser201 residue in FnYggS was the key residue for PLP binding. These results will expand the knowledge of the molecular properties and function of the YggS family.     

Effect of Different Processing Methods on the Chemical Constituents of Scrophulariae Radix as Revealed by 2D NMR-Based Metabolomics

Scrophulariae Radix (SR) is one of the oldest and most frequently used Chinese herbs for oriental medicine in China. Before clinical use, the SR should be processed using different methods after harvest, such as steaming, “sweating”, and traditional fire-drying. In order to investigate the difference in chemical constituents using different processing methods, the two-dimensional (2D) ¹H-¹³C heteronuclear single quantum correlation (¹H-¹³C HSQC)-based metabolomics approach was applied to extensively characterize the difference in the chemical components in the extracts of SR processed using different processing methods. In total, 20 compounds were identified as potential chemical markers that changed significantly with different steaming durations. Seven compounds can be used as potential chemical markers to differentiate processing by sweating, hot-air drying, and steaming for 4 h. These findings could elucidate the change of chemical constituents of the processed SR and provide a guide for the processing. In addition, our protocol may represent a general approach to characterizing chemical compounds of traditional Chinese medicine (TCM) and therefore might be considered as a promising approach to exploring the scientific basis of traditional processing of TCM.     

碘分子532nm激光稳频系统的参数优化

根据FM光谱通过吸收介质后,经检测、相干解调的理论分析,建立了线性吸收稳频的数学模型;得到不同调制频率和调制度的误差控制信号。由此给出用于碘分子线性吸收激光稳频的最佳调制频率和最佳调制度。     

硅基TFT有源矩阵液晶显示技术

介绍了薄膜晶体管（ＴＦＴ）,特别是ｐ－Ｓｉ（多晶硅）ＴＦＴ矩阵寻址液晶显示器的工作原理、结构、特点、制作工艺和电学特性,对器件参数的选择进行了分析     

Broadcast storm mitigation techniques in vehicular ad hoc networks

Several multihop applications developed for vehicular ad hoc networks use broadcast as a means to either discover nearby neighbors or propagate useful traffic information to other vehicles located within a certain geographical area. However, the conventional broadcast mechanism may lead to the so-called broadcast storm problem, a scenario in which there is a high level of contention and collisions at the link layer due to an excessive number of broadcast packets. While this is a well-known problem in mobile ad hoc wireless networks, only a few studies have addressed this issue in the VANET context, where mobile hosts move along the roads in a certain limited set of directions as opposed to randomly moving in arbitrary directions within a bounded area. Unlike other existing works, we quantify the impact of broadcast storms in VANETs in terms of message delay and packet loss rate in addition to conventional metrics such as message reachability and overhead. Given that VANET applications are currently confined to using the DSRC protocol at the data link layer, we propose three probabilistic and timer-based broadcast suppression techniques: weighted p-persistence, slotted 1-persistence, and slotted p-persistence schemes, to be used at the network layer. Our simulation results show that the proposed schemes can significantly reduce contention at the MAC layer by achieving up to 70 percent reduction in packet loss rate while keeping end-to-end delay at acceptable levels for most VANET applications.