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排序方式: 共有325条查询结果,搜索用时 15 毫秒
241.
It is shown that lithium aggregates promoted the efficient metalation of phenylpyridines and stabilization of phenylpyridyllithium. The BuLi-LiDMAE superbase prevented dimerization or nucleophilic addition encountered with t-BuLi or n-BuLi. The reported selective pyridine ring lithiation of 2-, 3-, and 4-phenylpyridine alpha to nitrogen opens a straightforward access to their derivatives. 相似文献
242.
Boyer V Fort S Frandsen TP Schülein M Cottaz S Driguez H 《Chemistry (Weinheim an der Bergstrasse, Germany)》2002,8(6):1389-1394
A new bifunctionalized cellohexaose derivative was synthesized as a specific substrate for continuous assay of cellulases by resonance energy transfer. This cellohexaoside has a naphthalene moiety (EDANS) as a fluorescent energy donor at the reducing end and a 4-(4'-dimethylaminobenzeneazo)-benzene derivative as an acceptor chromophore at the non-reducing end. The key steps for the preparation of the target molecule involved transglycosylation reactions of cellobiosyl and cellotetraosyl fluoride donors onto cellobiosyl acceptors catalysed by the E197A mutant of cellulase Cel7B from Humicola insolens. Upon digestion with various cellulases, the energy transfer was disrupted and an increase of fluorescence was observed. 相似文献
243.
Fort DM Ubillas RP Mendez CD Jolad SD Inman WD Carney JR Chen JL Ianiro TT Hasbun C Bruening RC Luo J Reed MJ Iwu M Carlson TJ King SR Bierer DE Cooper R 《The Journal of organic chemistry》2000,65(20):6534-6539
Two new compounds, pycnanthuquinone A (1) and pycnanthuquinone B (2), were isolated from leaves and stems of the African plant, Pycnanthus angolensis (Welw.) Warb (Myristicaceae), by bioassay-guided fractionation of an ethanolic extract using a diabetic mouse model. Pycnanthuquinones A and B are the first representatives of a novel terpenoid-type quinone skeleton, and both compounds possess significant antihyperglycemic activity. 相似文献
244.
Song S Peng C Gonzalez-Olivares MA Lopez-Valdivieso A Fort T 《Journal of colloid and interface science》2005,287(1):114-120
On the basis of the Einstein theory of viscosity of dispersion, a parameter, termed as solvation factor, is presented to evaluate the solvation degree of nanoscale particles dispersed in a liquid in this work. The value of the parameter is obtained through the measurements of relative viscosity of the dispersions as a function of the volume fraction of dry particles. The solvation factor has been used to study the hydration layers near nanoscale silica particles dispersed in water and aqueous electrolyte (NaCl and CaCl2) solutions in this work. The experimental results have shown that a strong hydration indeed applied to the silica surfaces in aqueous solutions, leaving a large volume of hydration layers on the surfaces. Also, it has been found that the hydration of the nanoscale silica particles could be greatly enhanced if they were dispersed in aqueous NaCl or CaCl2 solutions, which might be attributed to that the hydrated cations (Na+ or Ca2+) bind onto the silica/ water interface and thus increase the volume of the hydration layers. 相似文献
245.
Ada Bottaro Aruffo 《Annali di Matematica Pura ed Applicata》1980,123(1):105-160
Summary Nonconvex control problems of Bolza and Lagrange with state constraints are considered, in which the state is V-valued, with derivative V-valued, where VHVV is a Banach space and H is a Hilbert space. For these problems some existence theorems for the minimum are proved.
Lavoro eseguito nell'ambito del Laboratorio per la Matematica Applicata del C.N.R. presso l'Università di Genova. 相似文献
Lavoro eseguito nell'ambito del Laboratorio per la Matematica Applicata del C.N.R. presso l'Università di Genova. 相似文献
246.
Ada Bottaro Aruffo 《Annali di Matematica Pura ed Applicata》1980,125(1):367-389
Summary
We examine nonconvex problems of Bolza, in which the state is V-valued, with derivative V-valued, where VHV, V is a Banach space, V is its dual space and H is a Hilbert space. For these problems we prove some existence theorems for the minimum, when we consider state constraints and other constraints that are represented by a nonlinear differential equation that relates the state and the control.
Lavoro eseguito nell'ambito del Laboratorio per la Matematica Applicata del C.N.R. presso l'Università di Genova. 相似文献
Lavoro eseguito nell'ambito del Laboratorio per la Matematica Applicata del C.N.R. presso l'Università di Genova. 相似文献
247.
Urbani P Ramunno A Filosa R Pinto A Popolo A Bianchino E Piotto S Saturnino C De Prisco R Nicolaus B Tommonaro G 《Molecules (Basel, Switzerland)》2008,13(4):749-761
We report the synthesis, antioxidant and antiproliferative activity and a QSAR analysis of synthetic diphenylpropionamide derivatives. Synthesis of these compounds was achieved by direct condensation of 2,2- and 3,3-diphenylpropionic acid and appropriate amines using 1-propylphoshonic acid cyclic anhydride (PPAA) as catalyst. Compound structures were elucidated by NMR analysis and their melting points were measured. The in vitro antioxidant activity of these compounds was tested by evaluating the amount of scavenged ABTS radical and estimating ROS and NO production in LPS stimulated J774.A1 macrophages. All compounds were tested for their effect on viability of cells and results demonstrated that they are not toxic towards the cell lines used. The cytotoxic activity of all compounds was evaluated by a Brine Shrimp Test. 相似文献
248.
Alon Ben David Eran Diamant Eyal Dor Ada Barnea Niva Natan Lilach Levin Shira Chapman Lilach Cherry Mimran Eyal Epstein Ran Zichel Amram Torgeman 《Molecules (Basel, Switzerland)》2021,26(11)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) global pandemic. The first step of viral infection is cell attachment, which is mediated by the binding of the SARS-CoV-2 receptor binding domain (RBD), part of the virus spike protein, to human angiotensin-converting enzyme 2 (ACE2). Therefore, drug repurposing to discover RBD-ACE2 binding inhibitors may provide a rapid and safe approach for COVID-19 therapy. Here, we describe the development of an in vitro RBD-ACE2 binding assay and its application to identify inhibitors of the interaction of the SARS-CoV-2 RBD to ACE2 by the high-throughput screening of two compound libraries (LOPAC®1280 and DiscoveryProbeTM). Three compounds, heparin sodium, aurintricarboxylic acid (ATA), and ellagic acid, were found to exert an effective binding inhibition, with IC50 values ranging from 0.6 to 5.5 µg/mL. A plaque reduction assay in Vero E6 cells infected with a SARS-CoV-2 surrogate virus confirmed the inhibition efficacy of heparin sodium and ATA. Molecular docking analysis located potential binding sites of these compounds in the RBD. In light of these findings, the screening system described herein can be applied to other drug libraries to discover potent SARS-CoV-2 inhibitors. 相似文献
249.
de Lucas NC Correa RJ Albuquerque AC Firme CL Garden SJ Bertoti AR Netto-Ferreira JC 《The journal of physical chemistry. A》2007,111(6):1117-1122
Laser flash photolysis (LFP) studies, atoms in molecules (AIM) studies, and density functional theory (DFT) calculations have been performed in order to study the mechanism of the hydrogen abstraction by alpha-diketones in the presence of phenols. Laser irradiation of a degassed solution of 1,2-diketopyracene in acetonitrile resulted in the formation of a readily detectable transient with absorption at 610 nm, but with very low absorptivity. This transient decays with a lifetime of around 2 micros. The quenching rate constant for substituted phenols, kq, ranged from 1.10x10(8) L mol-1 s-1 (4-cyanophenol) to 3.87x10(9) L mol-1 s-1 (4-hydroxyphenol). The Hammett plot for the reaction of the triplet of 1,2-diketopyracene with phenols gave a reaction constant rho=-0.9. DFT calculations (UB3LYP/6-311++G**//UB3LYP/6-31G*) of the triplet complex ketone-phenol revealed that hydrogen transfer has predominantly occurred and that the reaction with alpha-diketones are generally 7 kcal/mol less endothermic than the respective reactions of the monoketones. These results together with the geometries obtained from the DFT calculations, natural bond order (NBO) analysis, and AIM results indicate that hydrogen abstraction for alpha-diketones is facilitated by the electrophilicity of the ketone, instead of neighboring group participation by the second carbonyl group. 相似文献
250.
Theoretical calculations on aggregation of nBuLi/lithium aminoalkoxide superbases, such as nBuLi/LiDMAE (LiDMAE = Me(2)N(CH(2))(2)OLi) and nBuLi/LiPM (LiPM = Li-N-methyl-2-pyrrolidine methoxide) in gas phase and solution are reported. The combination of equimolar amounts of each component in hexane induced unusual reactivity of the resulting superbase, which remains misunderstood. In order to elucidate the corresponding reaction mechanisms, it is imperative to get a deeper insight into the energetics of aggregation and the effect of the medium on equilibrium constants. In the present study, we compute and compare the stability of (nBuLi)(n), (LiPM)(n), and equimolecular mixed aggregates (nBuLi:LiPM)(n) in gas phase, hexane, and THF. Calculations have been carried out at the density functional theory level (B3LYP/6-31G(d)) using continuum and discrete continuum models of solvation. Higher-level calculations (MP2/aug-ccpVQZ) have been done in some cases for test purposes. Enthalpic and entropic contributions have been discussed and were shown to play an opposite role in hexane (or gas phase) and THF. The characteristics of LiPM and mixed nBuLi/LiPM solutions are found to be significantly different from those of nBuLi solutions. These calculations are in accordance with experimental data in both hexane and THF. Further comparison of theoretical and experimental results for gas-phase Li(+)-THF and Li(+)-DME complexes has enabled a discussion on computational errors for entropic contributions in THF. The value for the release of a THF solvent molecule is proposed to be DeltaS approximately 23 eu. These results provide new insights to the aggregation of organolithium compounds in solution and will be useful for the investigation of other systems. 相似文献