Ca2+掺杂对NaYF4:Yb,Er微米晶上转换发光性能的影响

采用柠檬酸钠辅助的水热方法制备了一系列不同Ca²⁺含量的Ca²⁺/Yb³⁺/Er³⁺共掺的NaYF₄微米片。利用透射电子显微镜(TEM)、X射线衍射分析(XRD)、发光光谱等测量手段对样品进行了形貌、晶相、发光性质的表征。样品在980 nm激光泵浦下,可以观察到强的上转换绿色荧光。在Ca²⁺的摩尔分数从0增加到8%的过程中,紫外到可见的上转换发光随着Ca²⁺浓度的增加而显著增强。这是由于Ca²⁺的掺杂导致了晶体内部的不对称性,同时也提高了晶体的结晶性。     

A novel electrochemical sensing strategy for rapid and ultrasensitive detection of Salmonella by rolling circle amplification and DNA–AuNPs probe

A novel electrochemical sensing strategy was developed for ultrasensitive and rapid detection of Salmonella by combining the rolling circle amplification with DNA–AuNPs probe. The target DNA could be specifically captured by probe 1 on the sensing interface. Then the circularization mixture was added to form a typical sandwich structure. In the presence of dNTPs and phi29 DNA polymerase, the RCA was initiated to produce micrometer-long single-strand DNA. Finally, the detection probe (DNA–AuNPs) could recognize RCA product to produce enzymatic electrochemical signal. Under optimal conditions, the calibration curve of synthetic target DNA had good linearity from 10 aM to 10 pM with a detection limit of 6.76 aM (S/N = 3). The developed method had been successfully applied to detect Salmonella as low as 6 CFU mL⁻¹ in real milk sample. This proposed strategy showed great potential for clinical diagnosis, food safety and environmental monitoring.     

中心粒子群优化算法

在线性递减权重粒子群优化算法(LDWPSO)中提到了中心粒子这一概念,进而提出了中心粒子群优化算法(中心PSO)。在线性递减权重粒子群优化算法中,中心粒子不像其它一般的粒子,中心粒子没有明确的速度,并且被始终置于粒子群的中心。此外,在神经网络训练算法中比较中心粒子群优化算法和线性递减权重粒子群优化算法,结果表明:中心粒子群优化算法的性能优于线性递减权重粒子群优化算法。     

5G基站电磁辐射

基于5G基站前向功率控制和波束赋形等关键技术,设计单用户情况下5G基站电磁辐射测试方案。该方案根据电磁辐射功率密度随着距离平方减小的规律布点,可以在一定程度上提高宏基站测试效率。对本文所提监测方案进行现场实测,监测结果远小于国际非电离辐射防护委员会(ICNIRP)标准限值,表明5G基站电磁辐射水平总体可控。利用高频结构仿真器(HFSS)设计5G基站天线模型获取大规模多输入多输出(MIMO)天线阵方向图,基于实际场景电磁参数分析搭建场景,通过射线追踪算法对5G基站的电磁辐射进行预测。预测与监测结果相比误差不大,证明预测方法可靠。     

Optimizing the Size of Micellar Nanoparticles for Efficient siRNA Delivery

Delivery of small interfering RNA (siRNA) by nanocarriers has shown promising therapeutic potential in cancer therapy. However, poor understanding of the correlation between the physicochemical properties of nanocarriers and their interactions with biological systems has significantly hindered its anticancer efficacy. Herein, in order to identify the optimal size of nanocarriers for siRNA delivery, different sized cationic micellar nanoparticles (MNPs) (40, 90, 130, and 180 nm) are developed that exhibit similar siRNA binding efficacies, shapes, surface charges, and surface chemistries (PEGylation) to ensure size is the only variable. Size‐dependent biological effects are carefully and comprehensively evaluated through both in vitro and in vivo experiments. Among these nanocarriers, the 90 nm MNPs show the optimal balance of prolonged circulation and cellular uptake by tumor cells, which result in the highest retention in tumor cells. In contrast, larger MNPs are rapidly cleared from the circulation and smaller MNPs are inefficiently taken up by tumor cells. Accordingly, 90 nm MNPs carrying polo‐like kinase 1 (Plk1)‐specific siRNA (siPlk1) show superior antitumor efficacy, indicating that 90 nm could either be the optimal size for systemic delivery of siRNA or close to it. Our findings provide valuable information for rationally designing nanocarriers for siRNA‐based cancer therapy in the future.     

Humidity‐Triggered Self‐Healing of Microporous Polyelectrolyte Multilayer Coatings for Hydrophobic Drug Delivery

Layer‐by‐layer (LbL) self‐assemblies have inherent potential as dynamic coatings because of the sensitivity of their building blocks to external stimuli. Here, humidity serves as a feasible trigger to activate the self‐healing of a microporous polyethylenimine/poly(acrylic acid) multilayer film. Microporous structures within the polyelectrolyte multilayer (PEM) film are created by acid treatment, followed by freeze‐drying to remove water. The self‐healing of these micropores can be triggered at 100% relative humidity, under which condition the mobility of the polyelectrolytes is activated. Based on this, a facile and versatile method is suggested for directly integrating hydrophobic drugs into PEM films for surface‐mediated drug delivery. The high porosity of microporous film enables the highest loading (≈303.5 μg cm^?2 for a 15‐bilayered film) of triclosan to be a one‐shot process via wicking action and subsequent solvent removal, thus dramatically streamlining the processes and reducing complexities compared to the existing LbL strategies. The self‐healing of a drug‐loaded microporous PEM film significantly reduces the diffusion coefficient of triclosan, which is favorable for the long‐term sustained release of the drug. The dynamic properties of this polymeric coating provide great potential for its use as a delivery platform for hydrophobic drugs in a wide variety of biomedical applications.     

基于CPSO的E型双频微带天线分析与设计

为满足多个无线通信系统实现多系统共用和收发共用,天线需在宽频带及不同频段下工作。通过在矩形微带贴片天线上开两条对称的缝隙而得到E型贴片微带天线,利用电磁仿真软件Ansoft HFSS建立天线模型,并运用自适应混沌粒子群算法对模型进行仿真优化。仿真分析结果表明,该天线具有很好的双频特性,能够满足设计需求。     

面向特殊领域的IMS网络架构模型研究

依托公众移动网络的无线接入体系,研究构建面向特殊领域应用的IP多媒体子系统(IMSP Multimedia Subsystem)网络架构,将对特殊领域用户的管理控制集中到内部IMS进行,可以满足特殊单位或部门对通信的特殊要求,实现对内部业务的自管自控,同时保证内部通信的安全保密.在对现有IMS架构进行了分析的基础上,提出面向特殊领域的IMS网络架构模型,并以注册流程和特殊用户之间的语音呼叫流程为例,研究探讨了系统的会话流程.     

基于LDDMA的多用户分集性能分析

针对线性离散多址复用（LDDMA）系统,文章研究在线性迫零（Zero-Force）接收机条件下的多用户选择分集与调度算法。对于用户子集选择算法,遍历搜索是最优的,但它所引起的繁重的计算复杂度,很难在实际中应用。基于此考虑,本文提出三种次优的贪婪选择准则：最大信道增益选择,最大信道容量选择与最大最小后验SNR选择。数值仿真结果表明：最大最小后验SNR准则可以提供较好的BER性能。