SISO仿射非线性系统自适应变结构BPNN控制

为了更好地消除抖振,提高复杂非线性系统的控制效果,针对一类典型SISO仿射非线性系统,提出了一种新的变结构神经网络自适应控制策略(VSYNC)。其中,对于系统未知非线性函数,将神经网络用作估计器。对控制输入加入连续函数项,其可以根据状态点和滑动切换面之间的距离自适应地调节不连续的控制变量,从而使变结构控制策略得到了显著提高。所提出的控制方法能够有效地抑制周围切换面的抖振,保证了系统地动态性能,同时还能够消除系统的稳态误差。仿真结果表明,该方法具有较高的控制精度和鲁棒性。     

Simultaneous screening of four epidermal growth factor receptor antagonists from Curcuma longa via cell membrane chromatography online coupled with HPLC–MS

The epidermal growth factor receptors (EGFRs) are significant targets for screening active compounds. In this work, an analytical method was established for rapid screening, separation, and identification of EGFRs antagonists from Curcuma longa. Human embryonic kidney 293 cells with a steadily high expression of EGFRs were used to prepare the cell membrane stationary phase in a cell membrane chromatography model for screening active compounds. Separation and identification of the retention chromatographic peaks was achieved by HPLC–MS. The active sites, docking extents and inhibitory effects of the active compounds were also demonstrated. The screening result found that ar‐turmerone, curcumin, demethoxycurcumin, and bisdemethoxycurcumin from Curcuma longa could be active components in a similar manner to gefitinib. Biological trials showed that all of four compounds can inhibit EGFRs protein secretion and cell growth in a dose‐dependent manner, and downregulate the phosphorylation of EGFRs. This analytical method demonstrated fast and effective characteristics for screening, separation and identification of the active compounds from a complex system and should be useful for drug discovery with natural medicinal herbs.     

动能杆定向抛撒规律的数值模拟

针对反导动能杆的定向抛撒 ,应用数值模拟软件AUTODYN 2D对动能杆的定向爆炸驱动和相互作用过程进行了数值仿真 ,获得了杆条抛撒速度和飞散角等变化规律。即在杆条排布结构不变的情况下 ,随装药弧度的减小 ,杆条的飞散角增大 ,而杆条飞散的平均速度则随装药弧度的减小而减小。与所进行的动能杆定向抛撒装置试验对比 ,试验结果与数值模拟结果基本一致。     

聚乙烯醇/羟基磷灰石复合材料的摩擦磨损性能研究

分别利用超声共混法和溶胶凝胶原位复合法制备出聚乙烯醇/羟基磷灰石(PVA-H/HA)复合材料,测定了其拉伸强度和抗剪切强度,并对不同HA含量下的试样进行了摩擦磨损性能研究.结果表明:少量HA的加入能提高复合材料的机械强度和抗磨损性能,利用原位复合法制备的试样机械性能较好,而且当HA含量为3%时复合材料的机械性能最佳;试样的磨损量随着接触载荷的增加而显著上升;在相同HA含量下,原位复合法制备的试样抗磨损性能更佳,当HA含量为4%时,原位复合法制备的复合材料试样的摩擦磨损性能最佳,其磨损量仅为纯PVA-H的29.8%.