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91.
de Kort M Regenbogen AD Valentijn AR Challiss RA Iwata Y Miyamoto S van der Marel GA van Boom JH 《Chemistry (Weinheim an der Bergstrasse, Germany)》2000,6(15):2696-2704
The synthesis, biological evaluation, and molecular modeling of two conformationally restricted analogues of adenophostinA (1), denominated as spirophostin (3R)-10 and (3S)-11, as novel ligands for the D-myo-inositol 1,4,5-trisphosphate receptor (IP3R), is presented. These diastereoisomeric spiroketals are synthesized by spiroketalization of D-glucose derivatives (2S)-15 and (2R)-16, separation of the protected isomers (3R)-19 and (3S)-20, followed by phosphorylation and deprotection. The spirophostins (3R)-10 and (3S)-11 display comparable biological activity, with a 3H-IP3-displacing and Ca2+-releasing potency less than IP3 and adenophostin A. 相似文献
92.
93.
Effective monitoring of residues of nortestosterone and its major metabolite in bovine urine and bile 总被引:1,自引:0,他引:1
L A van Ginkel R W Stephany H J van Rossum H van Blitterswijk P W Zoontjes R C Hooijschuur J Zuydendorp 《Journal of chromatography. A》1989,489(1):95-104
The results of a newly developed method for the detection and identification of residues of nortestosterone (NT) and one of its major metabolites, 17 alpha-nortestosterone (epiNT) are described. The method is based on sample clean-up by immunoaffinity chromatography and detection by high-performance liquid chromatography and/or gas chromatography-mass spectrometry (selected-ion monitoring). All samples of bile from calves that had been treated with NT contained significant amounts of epiNT (6-18 micrograms/l). The NT content of these samples, if detectable, was below 1 microgram/l. Urine contained, with one exception, less than 1 microgram/l epiNT. NT itself if detectable, was, present in urine or bile at levels below 0.1 microgram/l. The results corresponds well with results obtained with a radioimmunoassay procedure. 相似文献
94.
P.H.M. Budzelaar H.J. Alberts-Jansen K. Mollema J. Boersma G.J.M. van der Kerk A.L. Spek A.J.M. Duisenberg 《Journal of organometallic chemistry》1983,243(2):137-148
The stabilities of simple and internally coordinated organozinc-transition metal compounds towards disproportionation have been investigated by the microwave titration technique. Simple alkyl- and aryl-derivatives disproportionate to such an extent as to preclude isolation. Internal coordination was found to stabilize the asymmetric compounds, and several derivatives containing the dimethylaminopropyl group were isolated. The crystal structure of one of them, Me2N(CH2)3-ZnW(Cp)(CO)3, was determined by a single-crystal X-ray study. The crystals are orthorhombic, space group P212121, with four molecular units in a cell with parameters a 8.406(1), b 12.179(2) and c 16.642(2) Å. The structure was solved by standard Patterson and Fourier techniques. The refinement, with anisotropic temperature factors for the two heavy atoms, converged at RF = 0.092 (RwF = 0.089) for 1536 observed reflections with I>2.5σ(I). The molecule consists of a central tungsten atom, surrounded in a tetragonal pyramidal fashion by a cyclopentadienyl group in the apical position and three carbon monoxyde molecules and a zinc atom occupying the basal positions. The zinc atom is three-coordinate, being surrounded by the tungsten atom and the chelating dimethylaminopropyl group; there is, however, a short intermolecular contact between zinc and a carbonyl oxygen atom at 2.61(3) Å. 相似文献
95.
The CRISE computer program is used to correlate wavenumber regions and 6 structural elements containing carbon, hydrogen and oxygen on the basis of 2 standard files with 549 infrared and Raman spectra. The degree of correlation, including score percentages and interfering percentages, is established for different types of intervals in relation to various intensity thresholds. Specific regions (score 100%, interference 0%) proved to be rare, whereas pseudo-specific regions (score < 100%, interference 0%) are normally present. The usefulness of selective regions (score 100%, interference > 0%) is doubtful. The infrared and Raman results for a structural element can differ appreciably, yet neither technique is clearly superior for interpretative purposes. 相似文献
96.
Summary The application of GLC, HPLC and TLC to the analysis of pharmaceutical creams is discussed with special attention to sample clean-up. The results of the determination of hydrocortisone acetate, salicylic acid, benzoic acid, diethyl stilbestrol, chloramphenicol, diphenhydramine HCl, tretinoin and some cream base components by reversed phase HPLC are given.Presented at the 14th International Symposium on Chromatography London, September, 1982 相似文献
97.
Martin L. Bennink Dessy N. Nikova Kees O. van der Werf Jan Greve 《Analytica chimica acta》2003,479(1):3-15
Atomic force microscopy (AFM) imaging of static DNA-protein complexes, in air and in liquid, can be used to directly obtain quantitative and qualitative information on the structure of different complexes. For example, DNA length, the location of preferential binding sites for proteins and bending of DNA as a result of the complexation can all be measured. Recording consecutive AFM images of DNA and protein molecules under conditions that they are still able to move and interact, or dynamic AFM imaging, however, can reveal information on the dynamic aspects of the interactions between these molecules. Here, an overview is given of the technical challenges that need to be considered for successful dynamic AFM imaging studies of individual DNA-protein interactions. Necessary technical improvements to the AFM set-up and the development of new sample preparation methods are described in this paper. 相似文献
98.
David P. T. Steenvoorden Gerard M. J. Beijersbergen van Henegouwen 《Photochemistry and photobiology》1998,68(1):97-100
The photophysics of 5,10,15,20-tetraarylethynylporphyrinatozinc(II) complexes, 1 and 2, are reported. Compared to 5,10,15,20-tetraphenylporphyrinatozinc(II) (ZnTPP), the UV/visible spectra of 1 and 2 have red-shifted B and Q bands, with the Q bands of increased intensity relative to the B band. FIuorescence quantum yields and lifetimes and triplet quantum yields and lifetimes are similar to ZnTPP. However, quantum yields for in vitro singlet-oxygen generation are much larger than for ZnTPP and for 2 the quantum yield is near unity. These findings suggest that the title compounds could be potential lead compounds as sensitizers for photodynamic therapy. 相似文献
99.
100.