Synthesis and structure-activity relationships of N-substituted 2-[(2-imidazolylsulfinyl)methyl]anilines as a new class of gastric H+/K(+)-ATPase inhibitors.

A series of N-substituted 2-[(2-imidazolylsulfinyl)methyl]anilines (3) was synthesized and evaluated for its biological activity against gastric H+/K(+)-ATPase prepared from rabbit stomach and gastric acid secretions in Heidenhain pouch dogs. Monoalkyl substituents on the nitrogen atom of the aniline moiety markedly inhibited the enzyme activity to the same degree as omeprazole, a representative H+/K(+)-ATPase inhibitor. Most of these compounds, administered at 3 mg/kg i.v. inhibited histamine-stimulated gastric acid secretion. The inhibitory activity of these derivatives on the enzymes at pH 6.0 was more potent than that at pH 7.4, and was distinctly correlated to stability in aqueous solution at pH 5.0.     

A datalogger to identify vocalizing dolphins

A datalogger was developed to identify vocalizing dolphins within socially interacting captive groups. Every 50 ms the logger stores data on the level and frequency of detected sound. Dataloggers are temporarily attached to dolphins by suction cups for data collection sessions lasting up to 45 min. Later, computer analysis of data from the dataloggers reveals which dolphin produced each vocalization recorded during the session. Results from use of dataloggers with two captive bottlenose dolphins (Tursiops truncatus) at the New England Aquarium in Boston, MA are presented. The possible use of dataloggers with wild dolphins is discussed.     

Standard superfields in the harmonic formalism of supergauge theories

Scientific-Research Institute of Applied Physics; Tashkent State University. Translated from Teoreticheskaya i Matematicheskaya Fizika, Vol. 80, No. 3, pp. 391–398, September, 1989.     

Cathode spot energy transfer simulated by a focused laser beam

Minimum conditions for the formation of surface craters by laser irradiation were studied experimentally and theoretically for various metals. The critical power density for crater formation within 20 ns was about 10¹¹ W/m². It is therefore concluded that crater formation by ion bombardment requires an ion current density on the order of 10¹⁰ A/m²     

On an integral equation of the problem for an elastic strip with a slit

A new singular integral equation is obtained that describes the elastic equilibrium of a strip with both an inner and an edge slit (crack) and has a considerable advantage over existing equations /1–9/, etc.) from the viewpoint of a numerical realization and clarification of the analytical relationship with an analogous equation for a half-plane. Numerical results are given of a computation of the stress intensity coefficients at the tips of the inner and edge cracks that refine data in the literature.     

Two-fluid and population balance models for subcooled boiling flow

Population balance equations combined with a three-dimensional two-fluid model are employed to predict subcooled boiling flow at low pressure in a vertical annular channel. The MUSIG (MUltiple-SIze-Group) model implemented in the computer code CFX4.4 is further developed to accommodate the wall nucleation at the heated wall and condensation in the subcooled boiling regime. Comparison of model predictions against local measurements is made for the void fraction, bubble Sauter mean diameter and gas and liquid velocities covering a range of different mass and heat fluxes and inlet subcooling temperatures. Additional comparison using empirical relationships for the active nucelation site density and local bubble diameter is also investigated. Good agreement is achieved with the local radial void fraction, bubble Sauter diameter and liquid velocity profiles against measurements. However, significant weakness of the model is evidenced in the prediction of the vapour velocity. Work is in progress to circumvent the deficiency through the consideration of additional momentum equations or developing an algebraic slip model to account for bubble separation.     

Morphological and electronic properties of the thin film phase of pentacene investigated by AFM and STM/STS

We investigated the morphological, structural and electronic properties of Pentacene thin films grown by vacuum thermal evaporation on different inert substrates at room temperature. The results of our AFM and STM analysis give an interplanar spacing of 1.54 nm corresponding to the (0 0 1) distance of the so-called “thin film phase”. The STS measurements show an HOMO-LUMO gap of 2.2 eV.     

Uncertainties in air showers from small-x pQCD mini-jets

To investigate uncertainties in air shower simulations caused by the small-x regime, a model including leading-twist hard pQCD plus soft processes was built, which are separated by an energy dependent transverse momentum cut-off. We provide a fit of the cut-off to the total pp cross section for different PDFs using the eikonal formalism and show that for modern PDF sets there is only a small uncertainty in the mini-jet cross section, and hence in the finalstate multiplicity and the number of produced muons.