A special column highlighting young scientists at Institute of Chemistry,Chinese Academy of Sciences (ICCAS)

正Just seeing off the 60th anniversary of the Institute of Chemistry,Chinese Academy of Sciences(ICCAS),we are here with pleasure to conduct A Special Column for Young Scientists at ICCAS published in Chinese Chemistry Letters(CCL)endeavoring to disseminate positive energy of several enthusiastic chemists and spread their recent research to the global scientific community.The CCL is an official journal of the Chinese Chemical Society,     

Simultaneous determination of ginkgolides A,B, C and bilobalide by LC‐MS/MS and its application to a pharmacokinetic study in rats

The study of pharmacokinetics of Ginkgo biloba extracts in Traditional Chinese Medicine was relatively recent. In this study, a simple, quick and sensitive LC‐MS/MS analytical method was developed for the determination of ginkgolides A, B, C and bilobalide in rat plasma. The analytes were completely separated from the endogenous compounds on an Agilent Zorbax Eclipse plus C₁₈ column (50 mm × 3.0 mm, 1.8 µm) using an isocratic elution. The single‐run analysis time was as short as 5.0 min. Sample preparation for protein removal was accomplished used a simple methanol precipitation method, after SPE showing a simultaneous extraction and cleanup of extracts allowing for a direct analysis. Extraction recoveries in rat plasma for ginkgolides A, B, C and bilobalide ranged from 75.6% to 89.0%. The calibration curves were determined over the ranges 0.5–20,000 ng/mL for ginkgolides A, B, C and bilobalide respectively. The lower limits of quantification (LLOQ) of the analytes were 0.5 ng/mL. Inter‐day and intra‐day precision and accuracy were below 15% and between 85 and 115%, respectively. Finally, the developed method was successfully applied to a pharmacokinetic study following oral administration of the Ginkgo biloba extracts to the male ICR rats. Copyright © 2015 John Wiley & Sons, Ltd.     

远程反坦克导弹方案弹道研究

本文对定高飞行的远程反坦克导弹的方案弹道进行了探讨,给出了各典型弹道的数学模型,最后对末制导段的最佳制导规律进行了分析,可供远程反坦克导弹初步设计时参考。     

相反转乳化技术制备环氧树脂交联多孔微球

多孔微球在分离吸附、催化、涂料印刷等多方面具有潜在应用价值 .最近研究表明 ,当微孔孔径在 2 0 0～ 80 0ｎｍ范围时 ,由于强烈的光散射作用 ,多孔微球可以作为遮光剂使用[1] .Ｏｋｕｂｏ等用酸碱逐步处理法制备了一些共聚物的亚微米级多孔球[2～ 4] .Ｏｋｕｂｏ又用动态溶胀种子聚合法制备了微米级的聚合物微球 ,用类似的方法得到了多孔结构[5,6] .但这种方法涉及了许多烦琐过程并且产生了很多副产物需要处理 ,使得其费时费力而且成本相当高 .Ｓｃｈｌａｒｂ等发展了一种新的制备方法 ,在乳液聚合过程中引入有机溶剂 ,在实验后期除掉有机…     

核壳结构三维有序水凝胶的制备

随着科学技术的发展 ,人们不断地寻求具有新特性、新功能的高分子材料 .聚合物凝胶作为一种智能高分子材料 ,受到极大的关注[1,2 ] .聚合物凝胶具有外场响应特性 ,其体积可随外界环境如溶剂、温度、电场、磁场、ｐＨ值、化学物质或光照等条件的改变而变化 ,因而在药物可控释放、吸附分离及传感器等方面具有潜在应用价值 .对聚合物凝胶进行图案化处理 ,使之成为有序结构 ,大大拓宽了凝胶的应用范围 .Ｈｕ等[3 ,4 ] 首先报道了环境响应水凝胶表面图案的调控技术 ,图案的特征尺寸在微米级 ,此类凝胶作为光栅 ,在光纤、传感器和光通信中具有潜在…     

若干典型中空结构材料的模板合成与应用进展（英文）

中空结构材料作为一类新兴功能材料,具有可调空腔、高比例活性表面及强化的物质传递等特性;当多组分及功能被整合与分区时,可实现中空结构材料的非对称结构(Janus)的拓扑演化.本文重点介绍若干典型中空结构材料,包括Janus中空材料的模板合成方法进展及中空结构材料在催化、储能、油/水分离与药物递送等领域的潜在应用,并展望了中空结构材料的未来发展趋势.     

Hierarchical mesoporous silica wires by confined assembly

The assembly of silicate and surfactant confined within cylindrical alumina pore channels results in circular hexagonal, concentric lamellar and other unique mesostructures.     

磺化聚苯乙烯胶体晶的红外光谱分析

单分散乳胶体系可以通过自组装形成有序的胶体晶结构 ,在窄波段光过滤器[1] 、生物医学传感器[2 ] 、智能化学传感器[3] 等领域具有重要的应用价值 .最近 ,人们以此有序结构作为模板 ,制备了有序孔材料[4～ 7] .另外 ,此有序结构在仿生学如模拟蛋白石等有序结构等方面也具有重要意义[8] .但是 ,一般的单分散体系如聚苯乙烯体系所形成的有序结构都属于硬性材料 ,缺乏对外场的响应特性 .此外 ,微球表面没有功能性基团 ,很难与其它物质兼容 ,这使得其作为模板合成其它复合材料的潜力大大降低 .本实验室通过对聚合物胶体晶进行改性 ,使其成为功…     

Multiferroic behaviors of Co-doped Bi4NdTi3FeO15 ceramics

By using a multicalcination procedure, Co-doped Bi₄NdTi₃Fe${}_{1?x}$Co_xO₁₅ ($x=0.1,0.3,0.5\text{ and }0.7$) (Co_x) ceramics were synthesized. The samples showed a single-phase (SP) Aurivillius structure containing four perovskite layers. Plate-like morphology of the grains which is related to the layered perovskite structure of the samples was clearly observed by SEM. The multiferroic properties of the samples at room temperature (RT) were demonstrated by dielectric, ferroelectric and magnetic measurements. With x ranging from 0.1 to 0.7, all the samples show RT multiferroic properties although there is no obvious regularity between the Co content and the multiferroic property. Very interestingly, Co_0.3 sample exhibits the optimum RT magnetic property, which can be attributed to the inclination of occupying the inner octahedra center for doped Co ions and the nearly 1:1 ratio of Fe and Co ions in the inner octahedra. The present work offers new insight into the compositional design of promising lead-free RT multiferroic materials.     

Analysis of steroids by nonaqueous capillary electrophoresis

A simple method for the separation and determination of steroids (estradiol valerate, triamcinolone, levonorgestrel and ethinylestradiol) in single and compound tablets by nonaqueous capillary electrophoresis with ultraviolet (UV) spectrophotometric detection has been developed for the first time. After optimizing the electrophoretic parameters, including the nature of electrolytes and composition of organic solvent, the running buffers of methanol-acetonitrile (95: 5, v/v) containing 20 mM sodium acetate (pH 6.5) and methanol-acetonitrile (90: 10, v/v) containing 25 mM sodium acetate (pH 7.0) were found to be most suitable for determining estradiol valerate and triamcinolone, respectively. Reliable separation and simultaneous determination of levonorgestrel and ethinylestradiol were achieved in methanol containing 20 mM of ammonium acetate and 10 mM of sodium dodecyl sulfate (SDS). Tamoxifen was used as internal standard. Performance of the method, including migration time and peak area reproducibility, linearity, sensitivity and accuracy, were also evaluated. The limits of detection (S/N = 3) for four analytes were in the range of 9.8–19.5 μ g/mL. The relative standard deviations (RSD) of the migration times and peak areas of the analytes were in the range of 0.14–1.0% and 0.7–2.7% (intraday), 0.5–2.8% and 1.5–4.2% (interday), respectively. Within the tested concentration range, linear relationships between peak area ratios and concentrations of the analytes were obtained (correlation coefficients: 0.9987–0.9996). The method has been successfully applied to the determination of ingredients with recoveries over the range of 96.6–100.6%. The text was submitted by the authors in English.