Synthesis of 1-morpholino-1-(phenylethynyl)cycloalkanes from enamines and phenylacetylene in the presence of Cu(I) halides

1-Morpholino-1-(phenylethynyl)cyclopentane and 1-morpholino-1-(phenylethynyl)cyclohexane were obtained by reactions of enamines, derivatives of cyclic ketones, with phenylacetylene in the presence of CuI. A scheme for catalysis by Cu(I) compounds with the intermediate formation of copper phenylacetylide and iminium salts was suggested.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 169–170, January, 1994.     

Artefin — A new sesquiterpene lactone fromArtemesia filatovii

Two sesquiterpene lactones of the guaiane type have been isolatd from the epigeal part of Artemisia filatovii; one has been identified as isoepoxyestafiatin, while the other has proved to be new and has been named artefin. The structure of artefin has been established on the basis of spectral (IR, PMR) characteristics and x-ray structural analysis.Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 69–72, January–February, 1995. Original article submitted October 7, 1994.     

Synthesis of 19-hydroxysteroids. III. An investigation of approaches to the synthesis of 19-hydroxycortisol from cortisol and cortisone

Methods have been developed for the chemical transformation of cortisol and cortisone in derivatives of 19-hydroxycortisol.